CA2653480A1 - Formules de sels de prednisolone - Google Patents
Formules de sels de prednisolone Download PDFInfo
- Publication number
- CA2653480A1 CA2653480A1 CA002653480A CA2653480A CA2653480A1 CA 2653480 A1 CA2653480 A1 CA 2653480A1 CA 002653480 A CA002653480 A CA 002653480A CA 2653480 A CA2653480 A CA 2653480A CA 2653480 A1 CA2653480 A1 CA 2653480A1
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- CA
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- Prior art keywords
- tablet
- api
- weight
- amount
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000003117 prednisolones Chemical class 0.000 title claims abstract description 28
- 239000000203 mixture Substances 0.000 title description 24
- 238000009472 formulation Methods 0.000 title description 7
- -1 prednisolone sodium phosphates Chemical class 0.000 claims abstract description 15
- 239000002245 particle Substances 0.000 claims description 144
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 114
- 239000010410 layer Substances 0.000 claims description 88
- 238000000576 coating method Methods 0.000 claims description 75
- 230000000873 masking effect Effects 0.000 claims description 70
- 239000011248 coating agent Substances 0.000 claims description 64
- 239000000463 material Substances 0.000 claims description 59
- 239000011247 coating layer Substances 0.000 claims description 54
- 229960002943 prednisolone sodium phosphate Drugs 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 230000004584 weight gain Effects 0.000 claims description 27
- 235000019786 weight gain Nutrition 0.000 claims description 27
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 26
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 14
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 14
- 239000000725 suspension Substances 0.000 claims description 14
- 239000000796 flavoring agent Substances 0.000 claims description 13
- 235000019634 flavors Nutrition 0.000 claims description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
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- 239000000314 lubricant Substances 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 8
- JDOZJEUDSLGTLU-VWUMJDOOSA-N prednisolone phosphate Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 JDOZJEUDSLGTLU-VWUMJDOOSA-N 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 6
- 238000009826 distribution Methods 0.000 claims description 6
- 230000002411 adverse Effects 0.000 claims description 5
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- 239000000126 substance Substances 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- 239000011230 binding agent Substances 0.000 claims description 4
- 239000007884 disintegrant Substances 0.000 claims description 3
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- 238000007873 sieving Methods 0.000 claims description 3
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- 239000001488 sodium phosphate Substances 0.000 abstract 1
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- 239000002904 solvent Substances 0.000 description 28
- VJZLQIPZNBPASX-OJJGEMKLSA-L prednisolone sodium phosphate Chemical compound [Na+].[Na+].O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP([O-])([O-])=O)[C@@H]4[C@@H]3CCC2=C1 VJZLQIPZNBPASX-OJJGEMKLSA-L 0.000 description 27
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- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical class O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 13
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 9
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81001506P | 2006-06-01 | 2006-06-01 | |
| US60/810,015 | 2006-06-01 | ||
| US11/638,260 | 2006-12-13 | ||
| US11/638,216 | 2006-12-13 | ||
| US11/638,260 US20070281014A1 (en) | 2006-06-01 | 2006-12-13 | Prednisolone salt formulations |
| US11/638,216 US8637076B2 (en) | 2006-06-01 | 2006-12-13 | Prednisolone salt formulations |
| PCT/US2007/012883 WO2007143061A2 (fr) | 2006-06-01 | 2007-05-31 | Formules de sels de prednisolone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2653480A1 true CA2653480A1 (fr) | 2007-12-13 |
Family
ID=38616310
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002653485A Abandoned CA2653485A1 (fr) | 2006-06-01 | 2007-05-30 | Formulations de sel de prednisolone |
| CA002653480A Abandoned CA2653480A1 (fr) | 2006-06-01 | 2007-05-31 | Formules de sels de prednisolone |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002653485A Abandoned CA2653485A1 (fr) | 2006-06-01 | 2007-05-30 | Formulations de sel de prednisolone |
Country Status (3)
| Country | Link |
|---|---|
| CA (2) | CA2653485A1 (fr) |
| MX (2) | MX2008015059A (fr) |
| WO (2) | WO2007143131A2 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2926722B1 (fr) * | 2008-01-25 | 2010-09-03 | Substipharm Dev | Formulation pharmaceutique appropriee pour la preparation de comprimes orodispersibles de prednisolone |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE615854A (fr) * | ||||
| US3921636A (en) * | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device |
| US6740341B1 (en) * | 1998-11-25 | 2004-05-25 | Cima Labs Inc. | Taste masking rapid release coating system |
| CA2351720C (fr) * | 1998-11-25 | 2006-11-21 | Cima Labs Inc. | Systeme d'enrobage a liberation rapide masquant le gout |
| DE60213283T2 (de) * | 2001-12-20 | 2007-07-12 | Alpex Pharma S.A. | Pharmazeutische zusammensetzung enthaltend magermilchpulver |
| US8110223B2 (en) * | 2002-12-31 | 2012-02-07 | University Of Maryland, Baltimore | Methods for making pharmaceutical dosage forms containing active cushioning components |
| RU2382637C2 (ru) * | 2004-04-30 | 2010-02-27 | Астеллас Фарма Инк. | Фармацевтическая композиция для перорального введения в форме частиц с рассчитанным временем высвобождения и быстро распадающиеся таблетки, содержащие указанную композицию |
-
2007
- 2007-05-30 WO PCT/US2007/013008 patent/WO2007143131A2/fr active Application Filing
- 2007-05-30 MX MX2008015059A patent/MX2008015059A/es active IP Right Grant
- 2007-05-30 CA CA002653485A patent/CA2653485A1/fr not_active Abandoned
- 2007-05-31 CA CA002653480A patent/CA2653480A1/fr not_active Abandoned
- 2007-05-31 WO PCT/US2007/012883 patent/WO2007143061A2/fr active Application Filing
- 2007-05-31 MX MX2008015058A patent/MX2008015058A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007143131A3 (fr) | 2008-03-20 |
| WO2007143131A2 (fr) | 2007-12-13 |
| WO2007143131A9 (fr) | 2008-02-14 |
| CA2653485A1 (fr) | 2007-12-13 |
| WO2007143061A3 (fr) | 2008-02-14 |
| WO2007143061A2 (fr) | 2007-12-13 |
| MX2008015058A (es) | 2009-04-14 |
| MX2008015059A (es) | 2009-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20130531 |