CA2647163C - Modified macrophage migration inhibitory factor inhibitors - Google Patents

Modified macrophage migration inhibitory factor inhibitors Download PDF

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Publication number
CA2647163C
CA2647163C CA2647163A CA2647163A CA2647163C CA 2647163 C CA2647163 C CA 2647163C CA 2647163 A CA2647163 A CA 2647163A CA 2647163 A CA2647163 A CA 2647163A CA 2647163 C CA2647163 C CA 2647163C
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Prior art keywords
disease
compound
syndrome
autoimmune
mammal
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Expired - Fee Related
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CA2647163A
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English (en)
French (fr)
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CA2647163A1 (en
Inventor
Yousef Al-Abed
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Feinstein Institutes for Medical Research
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Feinstein Institutes for Medical Research
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    • C—CHEMISTRY; METALLURGY
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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CA2647163A 2006-03-24 2007-03-23 Modified macrophage migration inhibitory factor inhibitors Expired - Fee Related CA2647163C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78589806P 2006-03-24 2006-03-24
US60/785,898 2006-03-24
PCT/US2007/007319 WO2007112036A2 (en) 2006-03-24 2007-03-23 Modified macrophage migration inhibitory factor inhibitors

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CA2647163A1 CA2647163A1 (en) 2007-10-04
CA2647163C true CA2647163C (en) 2016-06-21

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CA2647163A Expired - Fee Related CA2647163C (en) 2006-03-24 2007-03-23 Modified macrophage migration inhibitory factor inhibitors

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US (2) US8362053B2 (enExample)
EP (1) EP2004192B1 (enExample)
JP (1) JP5523095B2 (enExample)
AU (1) AU2007230948B2 (enExample)
CA (1) CA2647163C (enExample)
WO (1) WO2007112036A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8362053B2 (en) * 2006-03-24 2013-01-29 The Feinstein Institute For Medical Research Modified macrophage migration inhibitory factor inhibitors
WO2015095052A1 (en) 2013-12-17 2015-06-25 Controlled Chemicals, Inc. Isoindolin-1-ones as macrophage migration inhibitory factor (mif) inhibitors
EP2944310B1 (en) 2014-05-16 2018-03-21 Mifcare MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
US9567306B2 (en) 2014-06-17 2017-02-14 The Feinstein Institute For Medical Research Inhibition of macrophage migration inhibitory factor in melanoma and colon cancer

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UY27304A1 (es) * 2001-05-24 2002-12-31 Avanir Pharmaceuticals Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación
WO2002100332A2 (en) * 2001-06-08 2002-12-19 Cytokine Pharmasciences, Inc. Isoxazoline compounds having mif antagonist activity
EP1727542A4 (en) 2004-03-26 2009-08-05 Cytokine Pharmasciences Inc COMPOUNDS, COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE FOR INHIBITING MACROPHAGE MIGRATION INHIBITION FACTOR
EP1740167B1 (en) * 2004-03-29 2013-08-28 The Feinstein Institute for Medical Research Treatment of type 1 diabetes with inhibitors of macrophage migration inhibitory factor
US8193247B2 (en) * 2006-03-24 2012-06-05 The Feinstein Institute For Medical Research Phenolic hydrazone macrophage migration inhibitory factor inhibitors
US8362053B2 (en) * 2006-03-24 2013-01-29 The Feinstein Institute For Medical Research Modified macrophage migration inhibitory factor inhibitors
EP2023732A4 (en) * 2006-06-05 2011-10-05 The Feinstein Inst Medical Res OXIME DERIVATIVES AS INHIBITORS OF THE MACROPHAGE MIGRATION INHIBITOR FACTOR
KR100971336B1 (ko) 2008-06-09 2010-07-20 삼성에스디아이 주식회사 보호회로모듈 및 이를 포함하는 이차전지

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AU2007230948B2 (en) 2012-06-28
US8362053B2 (en) 2013-01-29
EP2004192A2 (en) 2008-12-24
WO2007112036A2 (en) 2007-10-04
AU2007230948A1 (en) 2007-10-04
JP2009530404A (ja) 2009-08-27
EP2004192A4 (en) 2010-04-28
EP2004192B1 (en) 2014-03-12
US8618147B2 (en) 2013-12-31
WO2007112036A3 (en) 2008-01-03

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