CA2645185A1 - 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin d3 analogs and uses thereof - Google Patents
2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin d3 analogs and uses thereof Download PDFInfo
- Publication number
- CA2645185A1 CA2645185A1 CA002645185A CA2645185A CA2645185A1 CA 2645185 A1 CA2645185 A1 CA 2645185A1 CA 002645185 A CA002645185 A CA 002645185A CA 2645185 A CA2645185 A CA 2645185A CA 2645185 A1 CA2645185 A1 CA 2645185A1
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Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Public Health (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Diabetes (AREA)
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- Endocrinology (AREA)
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- Oncology (AREA)
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- Transplantation (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74438106P | 2006-04-06 | 2006-04-06 | |
| US60/744,381 | 2006-04-06 | ||
| PCT/IB2007/003143 WO2008035206A2 (en) | 2006-04-06 | 2007-04-06 | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin d3 analogs and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2645185A1 true CA2645185A1 (en) | 2008-03-27 |
Family
ID=39200903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002645185A Abandoned CA2645185A1 (en) | 2006-04-06 | 2007-04-06 | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin d3 analogs and uses thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8575136B2 (enExample) |
| EP (1) | EP2001841B1 (enExample) |
| JP (1) | JP2009532457A (enExample) |
| AU (1) | AU2007298651A1 (enExample) |
| CA (1) | CA2645185A1 (enExample) |
| MX (1) | MX2008012672A (enExample) |
| NZ (1) | NZ570712A (enExample) |
| WO (1) | WO2008035206A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575136B2 (en) | 2006-04-06 | 2013-11-05 | Wisconsin Alumni Research Foundation | 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4188345A (en) * | 1978-07-26 | 1980-02-12 | Wisconsin Alumni Research Foundation | Fluorovitamin D compounds and processes for their preparation |
| US4411833A (en) * | 1982-05-26 | 1983-10-25 | Wisconsin Alumni Research Foundation | Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol |
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US4970203A (en) * | 1988-12-09 | 1990-11-13 | Deluca Hector F | Method for improving reproductive functions in mammals |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP2898882B2 (ja) * | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| US5880114A (en) * | 1993-06-16 | 1999-03-09 | Wisconsin Alumni Research Foundation | Treatment of immune deficiency with vitamin D compounds |
| US6291444B1 (en) * | 1993-06-16 | 2001-09-18 | Wisconsin Alumni Research Foundation | Treatment of t-cell immunodeficiencies with vitamin D compounds |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US5825133A (en) * | 1996-09-25 | 1998-10-20 | Rockwell International | Resonant inverter for hot cathode fluorescent lamps |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6306844B1 (en) * | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US6382071B1 (en) * | 2000-08-07 | 2002-05-07 | Gilbert A. Bertani | Bola capturing apparatus |
| AU7544501A (en) * | 2000-09-08 | 2002-03-22 | Wisconsin Alumni Res Found | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| US20030018017A1 (en) | 2001-01-25 | 2003-01-23 | Deluca Hector F. | Method of treatment of type I diabetes |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| WO2003051828A2 (en) * | 2001-12-13 | 2003-06-26 | Wisconsin Alumni Research Foundation | (20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| NZ542674A (en) * | 2003-04-10 | 2009-03-31 | Wisconsin Alumni Res Found | 2-Propylidene-19-nor-vitamin D compounds |
| US20050009792A1 (en) | 2003-07-08 | 2005-01-13 | Deluca Hector F. | (20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3 and its uses |
| WO2005051396A2 (en) * | 2003-11-25 | 2005-06-09 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
| WO2005051323A2 (en) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| WO2006057884A2 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2α-METHYL AND 2ß-METHYL ANALOGS OF 19,26,27-TRINOR-(20S)-1α-HYDROXYVITAMIN D3 AND THEIR USES |
| US7803789B2 (en) * | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
| US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
| US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
| US8575136B2 (en) | 2006-04-06 | 2013-11-05 | Wisconsin Alumni Research Foundation | 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| NZ570814A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
| MX2010007956A (es) * | 2008-01-22 | 2010-09-14 | Wisconsin Alumni Reasearch Fou | Analogos de 13,13-dimetil-des-c,d de compuestos de 1a,25-dihidroxi-19-nor-vitamina d3 y formas de dosificacion de composicion topica y metodos de tratamiento de condiciones de la piel. |
| US8193170B2 (en) * | 2008-07-10 | 2012-06-05 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs |
| US8399439B2 (en) * | 2008-07-10 | 2013-03-19 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs |
| US20120283228A1 (en) * | 2011-05-03 | 2012-11-08 | Wisconsin Alumni Research Foundation | 2alpha-Methyl and 2beta-Methyl Analogs of 19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 and Their Uses |
-
2007
- 2007-04-06 US US11/697,414 patent/US8575136B2/en not_active Expired - Fee Related
- 2007-04-06 EP EP07848816A patent/EP2001841B1/en not_active Not-in-force
- 2007-04-06 JP JP2009503689A patent/JP2009532457A/ja not_active Ceased
- 2007-04-06 WO PCT/IB2007/003143 patent/WO2008035206A2/en not_active Ceased
- 2007-04-06 CA CA002645185A patent/CA2645185A1/en not_active Abandoned
- 2007-04-06 NZ NZ570712A patent/NZ570712A/en not_active IP Right Cessation
- 2007-04-06 MX MX2008012672A patent/MX2008012672A/es not_active Application Discontinuation
- 2007-04-06 AU AU2007298651A patent/AU2007298651A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2001841A2 (en) | 2008-12-17 |
| WO2008035206A2 (en) | 2008-03-27 |
| MX2008012672A (es) | 2008-10-15 |
| WO2008035206A3 (en) | 2008-06-05 |
| US20070238701A1 (en) | 2007-10-11 |
| NZ570712A (en) | 2011-11-25 |
| US8575136B2 (en) | 2013-11-05 |
| JP2009532457A (ja) | 2009-09-10 |
| AU2007298651A1 (en) | 2008-03-27 |
| EP2001841B1 (en) | 2012-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140204 |