CA2641519A1 - Compositions and methods for modulating hemostasis using variant forms of activated factor v - Google Patents
Compositions and methods for modulating hemostasis using variant forms of activated factor v Download PDFInfo
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- CA2641519A1 CA2641519A1 CA002641519A CA2641519A CA2641519A1 CA 2641519 A1 CA2641519 A1 CA 2641519A1 CA 002641519 A CA002641519 A CA 002641519A CA 2641519 A CA2641519 A CA 2641519A CA 2641519 A1 CA2641519 A1 CA 2641519A1
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- hemophilia
- amino acids
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
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- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Immunology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
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| PCT/US2007/062720 WO2007101106A2 (en) | 2006-02-23 | 2007-02-23 | Compositions and methods for modulating hemostasis using variant forms of activated factor v |
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| CA2641519A1 true CA2641519A1 (en) | 2007-09-07 |
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| EP2365822B1 (en) * | 2008-11-21 | 2015-07-01 | The Children's Hospital Of Philadelphia | Snake factor v and methods of use as a procoagulant |
| WO2012031240A2 (en) * | 2010-09-03 | 2012-03-08 | Richard Jenny | Therapeutics for trauma induced factor v consumptive coagulopathy |
| US8637448B2 (en) * | 2010-09-14 | 2014-01-28 | University Of Rochester | Recombinant factor VIII having enhanced stability following mutation at the A1-C2 domain interface |
| EP2766036B1 (en) * | 2011-10-13 | 2018-04-25 | The Children's Hospital of Philadelphia | Compositions and methods for modulating thrombin generation |
| AR101185A1 (es) * | 2014-07-11 | 2016-11-30 | Novo Nordiks As | Anticuerpos anti-factor v o factor v activado |
| EP3691673A4 (en) | 2017-10-05 | 2021-06-09 | Epivax, Inc. | REGULATORY T-LYMPHOCYTE EPITOPES |
| WO2019210187A1 (en) * | 2018-04-26 | 2019-10-31 | The University Of North Carolina At Chapel Hill | Methods and compositions for treatment of hemophilia |
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| WO2003100053A1 (en) * | 2002-05-22 | 2003-12-04 | The Children's Hospital Of Philadelphia | Compositions and methods for the treatment of hemophilia a |
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| EP2384764A2 (en) | 2011-11-09 |
| EP2384764A3 (en) | 2012-02-08 |
| EP1986681A4 (en) | 2010-08-04 |
| JP2009528293A (ja) | 2009-08-06 |
| US8236764B2 (en) | 2012-08-07 |
| US8470557B2 (en) | 2013-06-25 |
| WO2007101106A2 (en) | 2007-09-07 |
| US20090318344A1 (en) | 2009-12-24 |
| AU2007220825A1 (en) | 2007-09-07 |
| IL193306A (en) | 2013-04-30 |
| EP1986681A2 (en) | 2008-11-05 |
| IL193306A0 (en) | 2011-08-01 |
| WO2007101106A3 (en) | 2008-11-27 |
| US20120288895A1 (en) | 2012-11-15 |
| AU2007220825B2 (en) | 2013-02-21 |
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