CA2638899C - Systemes de nano-administration visant une tumeur pour ameliorer la detection precoce par irm d'un cancer - Google Patents

Systemes de nano-administration visant une tumeur pour ameliorer la detection precoce par irm d'un cancer Download PDF

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Publication number
CA2638899C
CA2638899C CA2638899A CA2638899A CA2638899C CA 2638899 C CA2638899 C CA 2638899C CA 2638899 A CA2638899 A CA 2638899A CA 2638899 A CA2638899 A CA 2638899A CA 2638899 C CA2638899 C CA 2638899C
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Canada
Prior art keywords
antibody
imaging
administration
antibody fragment
targeted
Prior art date
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Expired - Fee Related
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CA2638899A
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English (en)
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CA2638899A1 (fr
Inventor
Esther H. Chang
Kathleen F. Pirollo
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Georgetown University
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Georgetown University
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Publication of CA2638899C publication Critical patent/CA2638899C/fr
Expired - Fee Related legal-status Critical Current
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2881Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461Dispersions, colloids, emulsions or suspensions
    • A61K49/0466Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • A61K49/1812Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne une méthode pour fabriquer des immunoliposomes visant des fragments d'anticorps ou des anticorps pour administration systémique de molécules dans le but de traiter et de produire une image de maladies, y compris des tumeurs cancéreuses. L'invention concerne aussi des immunoliposomes et des compositions, ainsi que des méthodes d'imagerie de divers tissus. Les complexes de liposomes sont utiles pour l'encapsulation d'agents d'imagerie, par exemple, à utiliser en imagerie par résonance magnétique. La spécificité du dispositif d'administration découle du ciblage des anticorps ou des fragments d'anticorps.
CA2638899A 2005-10-20 2006-10-20 Systemes de nano-administration visant une tumeur pour ameliorer la detection precoce par irm d'un cancer Expired - Fee Related CA2638899C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72830305P 2005-10-20 2005-10-20
US60/728,303 2005-10-20
PCT/US2006/041139 WO2007047981A2 (fr) 2005-10-20 2006-10-20 Systèmes de nano-administration visant une tumeur pour améliorer la détection précoce par irm d'un cancer

Publications (2)

Publication Number Publication Date
CA2638899A1 CA2638899A1 (fr) 2007-04-26
CA2638899C true CA2638899C (fr) 2016-01-05

Family

ID=37963345

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2638899A Expired - Fee Related CA2638899C (fr) 2005-10-20 2006-10-20 Systemes de nano-administration visant une tumeur pour ameliorer la detection precoce par irm d'un cancer

Country Status (8)

Country Link
JP (1) JP5478886B2 (fr)
KR (1) KR20080064169A (fr)
CN (1) CN101351225B (fr)
AU (1) AU2006304790B2 (fr)
CA (1) CA2638899C (fr)
HK (1) HK1129063A1 (fr)
IL (1) IL190773A (fr)
WO (1) WO2007047981A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101570886B1 (ko) * 2007-07-09 2015-11-23 조지타운 유니버시티 양이온성-리포솜 매개된 핵산 전달을 이용하여 면역 반응을 생성시키는 방법
US8320647B2 (en) 2007-11-20 2012-11-27 Olea Medical Method and system for processing multiple series of biological images obtained from a patient
EP4241767A3 (fr) * 2008-11-10 2023-11-01 Arbutus Biopharma Corporation Nouveaux lipides et compositions d'administration d'agents thérapeutiques
CN102078624B (zh) * 2010-12-23 2012-07-25 华东理工大学 一种高效载钆脂质体制剂及其制备方法
WO2013031619A1 (fr) * 2011-08-26 2013-03-07 学校法人藤田学園 Agent de diagnostic de tumeur à base d'image contenant un anticorps du récepteur d'anti-transferrine humaine
CN103655475B (zh) * 2012-09-19 2020-04-28 乔治敦大学 靶向的脂质体
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
EP2968598B1 (fr) 2013-03-14 2020-05-27 Georgetown University Traitement après l'exposition à un agent neurotoxique
JP2021523145A (ja) * 2018-05-08 2021-09-02 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 磁性リポソームおよび関連する治療ならびにイメージング方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3902794B2 (ja) * 1997-03-07 2007-04-11 マックス−デルブルック−セントラム フュア モレクラーレ メディシン 特異的磁気体、その製造方法及び使用
EP1811036B8 (fr) * 1999-02-22 2011-09-21 Georgetown University Immunolipsomes ciblés sur un fragment d'anticorps utiles pour l'administration systemique d'un gène
US7780882B2 (en) * 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
EP1278512A2 (fr) * 2000-05-03 2003-01-29 MBT Munich Biotechnology AG Agents de diagnostic cationique, d'imagerie et de therapie associes a des sites vasculaires actives
JP2006505498A (ja) * 2002-04-03 2006-02-16 シー,ジャッキー アール. 病変組織の超音波イメージング及び処置方法
WO2004066946A2 (fr) * 2003-01-28 2004-08-12 Georgetown University Procede pour l'evaluation de l'efficacite de certains traitements du cancer
DK1633327T3 (da) * 2003-06-04 2010-11-15 Univ Georgetown Fremgangsmåde til forbedring af stabilitet og opbevaringslevetid af liposomkomplekser
EP1648299A4 (fr) * 2003-07-09 2008-10-22 California Pacific Med Center Detection a distance de la diffusion de substances aux cellules
JP2005170807A (ja) * 2003-12-09 2005-06-30 Fuji Photo Film Co Ltd 抗体を含むリポソーム

Also Published As

Publication number Publication date
AU2006304790A1 (en) 2007-04-26
CN101351225A (zh) 2009-01-21
CN101351225B (zh) 2013-09-25
JP5478886B2 (ja) 2014-04-23
HK1129063A1 (en) 2009-11-20
IL190773A (en) 2012-06-28
KR20080064169A (ko) 2008-07-08
IL190773A0 (en) 2008-11-03
CA2638899A1 (fr) 2007-04-26
JP2009512712A (ja) 2009-03-26
AU2006304790B2 (en) 2013-06-27
WO2007047981A2 (fr) 2007-04-26
WO2007047981A3 (fr) 2007-10-25

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