CA2637617C - System and method for correcting primer extension errors in nucleic acid sequence data - Google Patents

System and method for correcting primer extension errors in nucleic acid sequence data Download PDF

Info

Publication number
CA2637617C
CA2637617C CA2637617A CA2637617A CA2637617C CA 2637617 C CA2637617 C CA 2637617C CA 2637617 A CA2637617 A CA 2637617A CA 2637617 A CA2637617 A CA 2637617A CA 2637617 C CA2637617 C CA 2637617C
Authority
CA
Canada
Prior art keywords
value
corrected
signal
flowgram
parameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2637617A
Other languages
English (en)
French (fr)
Other versions
CA2637617A1 (en
Inventor
Yi-Ju Chen
Keith Mcdade
John Simpson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
454 Life Science Corp
Original Assignee
454 Life Science Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 454 Life Science Corp filed Critical 454 Life Science Corp
Publication of CA2637617A1 publication Critical patent/CA2637617A1/en
Application granted granted Critical
Publication of CA2637617C publication Critical patent/CA2637617C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6848Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Software Systems (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA2637617A 2006-02-16 2007-02-15 System and method for correcting primer extension errors in nucleic acid sequence data Expired - Fee Related CA2637617C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77435406P 2006-02-16 2006-02-16
US60/774,354 2006-02-16
PCT/US2007/004187 WO2007098049A2 (en) 2006-02-16 2007-02-15 System and method for correcting primer extension errors in nucleic acid sequence data

Publications (2)

Publication Number Publication Date
CA2637617A1 CA2637617A1 (en) 2007-08-30
CA2637617C true CA2637617C (en) 2018-09-18

Family

ID=38437895

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2637617A Expired - Fee Related CA2637617C (en) 2006-02-16 2007-02-15 System and method for correcting primer extension errors in nucleic acid sequence data

Country Status (7)

Country Link
US (2) US8301394B2 (https=)
EP (2) EP2578702A1 (https=)
JP (2) JP5808515B2 (https=)
CN (1) CN101390101B (https=)
CA (1) CA2637617C (https=)
ES (1) ES2626620T3 (https=)
WO (1) WO2007098049A2 (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005003375A2 (en) 2003-01-29 2005-01-13 454 Corporation Methods of amplifying and sequencing nucleic acids
ES2626620T3 (es) 2006-02-16 2017-07-25 454 Life Sciences Corporation Sistema y método para corregir errores de extensión de cebadores en datos de secuencias de ácidos nucleicos
US8364417B2 (en) * 2007-02-15 2013-01-29 454 Life Sciences Corporation System and method to correct out of phase errors in DNA sequencing data by use of a recursive algorithm
US8407554B2 (en) * 2009-02-03 2013-03-26 Complete Genomics, Inc. Method and apparatus for quantification of DNA sequencing quality and construction of a characterizable model system using Reed-Solomon codes
TWI439548B (zh) * 2009-12-23 2014-06-01 Ind Tech Res Inst 序列校正方法與序列校正裝置
US9194838B2 (en) 2010-03-03 2015-11-24 Osaka University Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide
EP2952590B1 (en) 2010-06-11 2017-07-26 Life Technologies Corporation Alternative nucleotide flows in sequencing-by-synthesis methods
NZ610129A (en) 2010-10-04 2014-08-29 Genapsys Inc Systems and methods for automated reusable parallel biological reactions
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
EP2633470B1 (en) * 2010-10-27 2016-10-26 Life Technologies Corporation Predictive model for use in sequencing-by-synthesis
US10273540B2 (en) 2010-10-27 2019-04-30 Life Technologies Corporation Methods and apparatuses for estimating parameters in a predictive model for use in sequencing-by-synthesis
WO2012071434A2 (en) * 2010-11-22 2012-05-31 Life Technologies Corporation Model-based residual correction of intensities
WO2012118555A1 (en) 2010-12-29 2012-09-07 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
WO2012092455A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
WO2012092515A2 (en) 2010-12-30 2012-07-05 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
WO2012138921A1 (en) 2011-04-08 2012-10-11 Life Technologies Corporation Phase-protecting reagent flow orderings for use in sequencing-by-synthesis
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
KR101940833B1 (ko) * 2011-05-27 2019-01-21 제납시스 인크. 유전자 및 생물학적 분석을 위한 시스템 및 방법
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
US20150087537A1 (en) 2011-08-31 2015-03-26 Life Technologies Corporation Methods, Systems, Computer Readable Media, and Kits for Sample Identification
US10093975B2 (en) 2011-12-01 2018-10-09 Genapsys, Inc. Systems and methods for high efficiency electronic sequencing and detection
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US10192024B2 (en) 2012-05-18 2019-01-29 454 Life Sciences Corporation System and method for generation and use of optimal nucleotide flow orders
CA2882001A1 (en) 2012-08-17 2014-02-20 Osaka University Sample analysis method
US10329608B2 (en) 2012-10-10 2019-06-25 Life Technologies Corporation Methods, systems, and computer readable media for repeat sequencing
JP6282036B2 (ja) 2012-12-27 2018-02-21 クオンタムバイオシステムズ株式会社 物質の移動速度の制御方法および制御装置
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US20140296080A1 (en) 2013-03-14 2014-10-02 Life Technologies Corporation Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood
EP2971141B1 (en) 2013-03-15 2018-11-28 Genapsys, Inc. Systems for biological analysis
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
US9926597B2 (en) 2013-07-26 2018-03-27 Life Technologies Corporation Control nucleic acid sequences for use in sequencing-by-synthesis and methods for designing the same
EP2840148B1 (en) 2013-08-23 2019-04-03 F. Hoffmann-La Roche AG Methods for nucleic acid amplification
EP3047282B1 (en) 2013-09-18 2019-05-15 Quantum Biosystems Inc. Biomolecule sequencing devices, systems and methods
US10410739B2 (en) 2013-10-04 2019-09-10 Life Technologies Corporation Methods and systems for modeling phasing effects in sequencing using termination chemistry
JP2015077652A (ja) 2013-10-16 2015-04-23 クオンタムバイオシステムズ株式会社 ナノギャップ電極およびその製造方法
WO2015062184A1 (en) 2013-11-01 2015-05-07 Accurascience, Llc Method and apparatus for calling single-nucleotide variations and other variations
US20160026756A1 (en) * 2013-11-01 2016-01-28 Origenome, Llc Method and apparatus for separating quality levels in sequence data and sequencing longer reads
WO2015089238A1 (en) 2013-12-11 2015-06-18 Genapsys, Inc. Systems and methods for biological analysis and computation
US10438811B1 (en) 2014-04-15 2019-10-08 Quantum Biosystems Inc. Methods for forming nano-gap electrodes for use in nanosensors
US9822401B2 (en) 2014-04-18 2017-11-21 Genapsys, Inc. Methods and systems for nucleic acid amplification
WO2016060974A1 (en) 2014-10-13 2016-04-21 Life Technologies Corporation Methods, systems, and computer-readable media for accelerated base calling
EP3295345B1 (en) 2015-05-14 2023-01-25 Life Technologies Corporation Barcode sequences, and related systems and methods
CN107958138B (zh) * 2016-10-14 2019-06-18 赛纳生物科技(北京)有限公司 一种从高通量dna测序的原始信号中读取序列信息的方法
CN116426621A (zh) * 2015-11-19 2023-07-14 赛纳生物科技(北京)有限公司 一种校正测序信息错误的方法
ES2877193T3 (es) 2016-04-27 2021-11-16 Quantum Biosystems Inc Sistemas y métodos para la medición y secuenciación de biomoléculas
US10619205B2 (en) 2016-05-06 2020-04-14 Life Technologies Corporation Combinatorial barcode sequences, and related systems and methods
WO2018017884A1 (en) 2016-07-20 2018-01-25 Genapsys, Inc. Systems and methods for nucleic acid sequencing
WO2019060628A1 (en) 2017-09-21 2019-03-28 Genapsys, Inc. SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING
CN114096682B (zh) 2019-05-03 2025-06-13 阿尔缇玛基因组学公司 通过合成方法的快进测序
CN114420214B (zh) * 2022-01-28 2026-02-27 赛纳生物科技(北京)有限公司 核酸测序数据的质量评估方法和筛选方法
CN116825189A (zh) * 2023-06-29 2023-09-29 赛纳生物科技(北京)有限公司 一种2+2测序的信号校正方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9620209D0 (en) * 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
GB9901475D0 (en) 1999-01-22 1999-03-17 Pyrosequencing Ab A method of DNA sequencing
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US6274320B1 (en) * 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US6783934B1 (en) * 2000-05-01 2004-08-31 Cepheid, Inc. Methods for quantitative analysis of nucleic acid amplification reaction
GB0016472D0 (en) * 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method and apparatus
WO2002019602A2 (en) * 2000-09-01 2002-03-07 Fred Hutchinson Cancer Research Center Statistical modeling to analyze large data arrays
US6952651B2 (en) * 2002-06-17 2005-10-04 Intel Corporation Methods and apparatus for nucleic acid sequencing by signal stretching and data integration
US20040197845A1 (en) * 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
WO2005003375A2 (en) * 2003-01-29 2005-01-13 454 Corporation Methods of amplifying and sequencing nucleic acids
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
GB0324456D0 (en) 2003-10-20 2003-11-19 Isis Innovation Parallel DNA sequencing methods
WO2005085273A1 (en) * 2004-03-04 2005-09-15 The University Of British Columbia Thrombomodulin (thbd) haplotypes predict outcome of patients
PT1801209E (pt) * 2004-08-24 2011-05-26 Toray Industries Arn gen?mico do v?rus humano modificado da hepatite c com capacidade de replica??o aut?noma
ES2626620T3 (es) 2006-02-16 2017-07-25 454 Life Sciences Corporation Sistema y método para corregir errores de extensión de cebadores en datos de secuencias de ácidos nucleicos

Also Published As

Publication number Publication date
EP2002367B1 (en) 2017-03-29
EP2002367A2 (en) 2008-12-17
EP2002367A4 (en) 2009-06-03
JP2013211043A (ja) 2013-10-10
US20100192032A1 (en) 2010-07-29
US20130054171A1 (en) 2013-02-28
JP2009527817A (ja) 2009-07-30
ES2626620T3 (es) 2017-07-25
WO2007098049A9 (en) 2007-10-25
EP2578702A1 (en) 2013-04-10
CN101390101B (zh) 2012-05-23
JP5746265B2 (ja) 2015-07-08
CA2637617A1 (en) 2007-08-30
WO2007098049A3 (en) 2008-08-07
CN101390101A (zh) 2009-03-18
WO2007098049A2 (en) 2007-08-30
JP5808515B2 (ja) 2015-11-10
US9587274B2 (en) 2017-03-07
US8301394B2 (en) 2012-10-30

Similar Documents

Publication Publication Date Title
CA2637617C (en) System and method for correcting primer extension errors in nucleic acid sequence data
US9317654B2 (en) System and method to correct out of phase errors in DNA sequencing data by use of a recursive algorithm
Cai et al. The perfect storm: gene tree estimation error, incomplete lineage sorting, and ancient gene flow explain the most recalcitrant ancient angiosperm clade, Malpighiales
Hu et al. Bayesian detection of convergent rate changes of conserved noncoding elements on phylogenetic trees
CN110832596B (zh) 基于深度学习的深度卷积神经网络训练方法
Allman et al. Identifying the rooted species tree from the distribution of unrooted gene trees under the coalescent
Tambe et al. Barcode identification for single cell genomics
US12597490B2 (en) Methods and systems for modeling phasing effects in sequencing using termination chemistry
Lindsay et al. Scalable genome scaffolding using integer linear programming
Sharma et al. Algorithmic and computational comparison of metagenome assemblers
Smith et al. Considerations of depth, coverage, and other read quality metrics
Liu et al. Confirmatory Biomarker Identification with k-FWER Control Using Derandomized Knockoffs with Cox Regression
Zaharia et al. Heterogeneous Graph Mining for Biological Pattern Discovery in Metabolic Pathways
Lindsay et al. Scaffolding Large Genomes using Integer Linear Programming
McComish Exploring biological sequence space: selected problems in sequence analysis and phylogenetics: a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Computational Biology at Massey University
Shen et al. Gene Expression Analysis Using RNA-Seq from Organisms Lacking Substantial Genomic Resources

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20210831

MKLA Lapsed

Effective date: 20200217