CA2629478C - Staurosporine derivatives for use in alveolar rhabdomyosarcoma - Google Patents

Staurosporine derivatives for use in alveolar rhabdomyosarcoma Download PDF

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Publication number
CA2629478C
CA2629478C CA2629478A CA2629478A CA2629478C CA 2629478 C CA2629478 C CA 2629478C CA 2629478 A CA2629478 A CA 2629478A CA 2629478 A CA2629478 A CA 2629478A CA 2629478 C CA2629478 C CA 2629478C
Authority
CA
Canada
Prior art keywords
typically
lower alkyl
radicals
phenyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2629478A
Other languages
English (en)
French (fr)
Other versions
CA2629478A1 (en
Inventor
Marco Wachtel
Beat W. Schafer
Ralf Amstutz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zurich Universitaet Institut fuer Medizinische Virologie
Original Assignee
Novartis Pharma GmbH Austria
Zurich Universitaet Institut fuer Medizinische Virologie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma GmbH Austria, Zurich Universitaet Institut fuer Medizinische Virologie filed Critical Novartis Pharma GmbH Austria
Publication of CA2629478A1 publication Critical patent/CA2629478A1/en
Application granted granted Critical
Publication of CA2629478C publication Critical patent/CA2629478C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2629478A 2005-11-14 2006-11-13 Staurosporine derivatives for use in alveolar rhabdomyosarcoma Expired - Fee Related CA2629478C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73622205P 2005-11-14 2005-11-14
US60/736,222 2005-11-14
PCT/EP2006/068410 WO2007054579A1 (en) 2005-11-14 2006-11-13 Staurosporine derivatives for use in alveolar rhabdomyosarcoma

Publications (2)

Publication Number Publication Date
CA2629478A1 CA2629478A1 (en) 2007-05-18
CA2629478C true CA2629478C (en) 2013-10-15

Family

ID=37758863

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2629478A Expired - Fee Related CA2629478C (en) 2005-11-14 2006-11-13 Staurosporine derivatives for use in alveolar rhabdomyosarcoma

Country Status (10)

Country Link
US (1) US7973032B2 (enExample)
EP (1) EP1951255A1 (enExample)
JP (1) JP5308820B2 (enExample)
KR (1) KR20080067654A (enExample)
CN (1) CN101304749A (enExample)
AU (1) AU2006313724B2 (enExample)
BR (1) BRPI0618571A2 (enExample)
CA (1) CA2629478C (enExample)
RU (1) RU2443421C2 (enExample)
WO (1) WO2007054579A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025132479A1 (en) * 2023-12-18 2025-06-26 Institut National de la Santé et de la Recherche Médicale Flt3 inhibitor for modulating macrophages polarization

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093330A (en) * 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
US7132458B2 (en) 1994-08-10 2006-11-07 Chemaphor Inc. Oxidized carotenoid fractions and ketoaldehyde useful as cell-differentiation inducers, cytostatic agents, and anti-tumor agents
WO1997004761A1 (en) 1995-07-28 1997-02-13 Trustees Of Boston University Methods and compositions for treating cell proliferative disorders
PL329851A1 (en) * 1996-05-01 1999-04-12 Lilly Co Eli Treatment of diseases associated with vegf
US7973031B2 (en) 2001-10-30 2011-07-05 Novartis Ag Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity
TWI324604B (en) * 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
MXPA06003056A (es) * 2003-09-19 2006-05-31 Novartis Ag Tratamiento de tumores estromales gastrointestinales con imatinib y midostaurin.
RU2269315C2 (ru) * 2004-05-24 2006-02-10 Рашид Кямиль Оглы Гусейнов Способ соединения сосудов и устройство для герметизации надреза сосуда и перерезания стенки сосуда

Also Published As

Publication number Publication date
US20080280880A1 (en) 2008-11-13
BRPI0618571A2 (pt) 2011-09-06
WO2007054579A1 (en) 2007-05-18
US7973032B2 (en) 2011-07-05
RU2008123382A (ru) 2009-12-27
KR20080067654A (ko) 2008-07-21
CA2629478A1 (en) 2007-05-18
AU2006313724B2 (en) 2010-12-23
JP5308820B2 (ja) 2013-10-09
EP1951255A1 (en) 2008-08-06
JP2009515858A (ja) 2009-04-16
RU2443421C2 (ru) 2012-02-27
AU2006313724A1 (en) 2007-05-18
CN101304749A (zh) 2008-11-12

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20151113