CA2629249C - Combination treatment of cancer comprising egfr/her2 inhibitors - Google Patents

Combination treatment of cancer comprising egfr/her2 inhibitors Download PDF

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Publication number
CA2629249C
CA2629249C CA2629249A CA2629249A CA2629249C CA 2629249 C CA2629249 C CA 2629249C CA 2629249 A CA2629249 A CA 2629249A CA 2629249 A CA2629249 A CA 2629249A CA 2629249 C CA2629249 C CA 2629249C
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Canada
Prior art keywords
amino
cancer
use according
agent
cancers
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CA2629249A
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English (en)
French (fr)
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CA2629249A1 (en
Inventor
Flavio Solca
Andree Amelsberg
Gerd Stehle
Jacobus C. A. Van Meel
Anke Baum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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Publication of CA2629249A1 publication Critical patent/CA2629249A1/en
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Publication of CA2629249C publication Critical patent/CA2629249C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2629249A 2005-11-11 2006-11-09 Combination treatment of cancer comprising egfr/her2 inhibitors Active CA2629249C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05110669.8 2005-11-11
EP05110669 2005-11-11
PCT/EP2006/068314 WO2007054551A1 (en) 2005-11-11 2006-11-09 Combination treatment of cancer comprising egfr/her2 inhibitors

Publications (2)

Publication Number Publication Date
CA2629249A1 CA2629249A1 (en) 2007-05-18
CA2629249C true CA2629249C (en) 2015-05-05

Family

ID=37658836

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2629249A Active CA2629249C (en) 2005-11-11 2006-11-09 Combination treatment of cancer comprising egfr/her2 inhibitors

Country Status (11)

Country Link
US (3) US20090306101A1 (https=)
EP (2) EP1948180B1 (https=)
JP (1) JP2009515852A (https=)
CA (1) CA2629249C (https=)
CY (1) CY1114040T1 (https=)
DK (1) DK1948180T3 (https=)
ES (1) ES2412879T3 (https=)
PL (1) PL1948180T3 (https=)
PT (1) PT1948180E (https=)
SI (1) SI1948180T1 (https=)
WO (1) WO2007054551A1 (https=)

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Also Published As

Publication number Publication date
EP2340837A1 (en) 2011-07-06
US20140199298A1 (en) 2014-07-17
EP2340837B1 (en) 2017-03-15
EP1948180A1 (en) 2008-07-30
US20180086744A1 (en) 2018-03-29
DK1948180T3 (da) 2013-05-27
CA2629249A1 (en) 2007-05-18
EP1948180B1 (en) 2013-03-13
CY1114040T1 (el) 2016-07-27
PT1948180E (pt) 2013-05-10
SI1948180T1 (sl) 2013-06-28
ES2412879T3 (es) 2013-07-12
WO2007054551A1 (en) 2007-05-18
JP2009515852A (ja) 2009-04-16
PL1948180T3 (pl) 2013-09-30
US20090306101A1 (en) 2009-12-10

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EEER Examination request