CA2625763A1 - Quaternary alpha-aminocarboxamide derivatives as modulators of voltage-gated sodium channels - Google Patents
Quaternary alpha-aminocarboxamide derivatives as modulators of voltage-gated sodium channels Download PDFInfo
- Publication number
- CA2625763A1 CA2625763A1 CA002625763A CA2625763A CA2625763A1 CA 2625763 A1 CA2625763 A1 CA 2625763A1 CA 002625763 A CA002625763 A CA 002625763A CA 2625763 A CA2625763 A CA 2625763A CA 2625763 A1 CA2625763 A1 CA 2625763A1
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- Prior art keywords
- methyl
- phenyl
- oxy
- fluorophenyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0520578A GB0520578D0 (en) | 2005-10-10 | 2005-10-10 | Novel compounds |
| GB0520578.6 | 2005-10-10 | ||
| GB0523030.5 | 2005-11-11 | ||
| GB0523030A GB0523030D0 (en) | 2005-11-11 | 2005-11-11 | Novel compounds |
| GB0603897.0 | 2006-02-27 | ||
| GB0603897A GB0603897D0 (en) | 2006-02-27 | 2006-02-27 | Novel compounds |
| GB0609159.9 | 2006-05-09 | ||
| GB0609159A GB0609159D0 (en) | 2006-05-09 | 2006-05-09 | Novel Compounds |
| GB0618511A GB0618511D0 (en) | 2006-09-20 | 2006-09-20 | Novel compounds |
| GB0618511.0 | 2006-09-20 | ||
| PCT/EP2006/009732 WO2007042240A1 (en) | 2005-10-10 | 2006-10-06 | Quaternary alpha-aminocarboxamide derivatives as modulators of voltage-gated sodium channels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2625763A1 true CA2625763A1 (en) | 2007-04-19 |
Family
ID=37762326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002625763A Abandoned CA2625763A1 (en) | 2005-10-10 | 2006-10-06 | Quaternary alpha-aminocarboxamide derivatives as modulators of voltage-gated sodium channels |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7803833B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1934176B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5139306B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20080059297A (cg-RX-API-DMAC7.html) |
| AR (1) | AR057869A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE543797T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006301471A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0617189A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2625763A1 (cg-RX-API-DMAC7.html) |
| CR (1) | CR9926A (cg-RX-API-DMAC7.html) |
| EA (1) | EA200801068A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2381686T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL190544A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20082122L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ567030A (cg-RX-API-DMAC7.html) |
| PE (1) | PE20070495A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200728258A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007042240A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200730494A (en) * | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
| WO2007042250A1 (en) * | 2005-10-10 | 2007-04-19 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
| GB0701365D0 (en) * | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0701366D0 (en) * | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0706630D0 (en) * | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
| ES2536694T3 (es) | 2009-09-14 | 2015-05-27 | Convergence Pharmaceuticals Limited | Procedimiento para preparar derivados de alfa-carboxamida |
| JP2011232320A (ja) * | 2009-10-01 | 2011-11-17 | Sony Corp | 生体内物質検出用プローブ、および該生体内物質検出用プローブを用いた生体内物質検出装置 |
| ES2786298T3 (es) | 2011-03-03 | 2020-10-09 | Zalicus Pharmaceuticals Ltd | Inhibidores de benzimidazol del canal de sodio |
| GB201122113D0 (en) | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| GB201209015D0 (en) * | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
| GB201209670D0 (en) * | 2012-05-31 | 2012-07-18 | Convergence Pharmaceuticals | Novel compounds |
| US10421716B2 (en) | 2014-12-23 | 2019-09-24 | Convergence Pharmaceuticals Limited | Process for preparing alpha-carboxamide pyrrolidine derivatives |
| WO2016160574A2 (en) * | 2015-03-27 | 2016-10-06 | Scifluor Life Sciences, Inc. | Aryl- and heteroaryl-pyrrolidine-2-carboxamide compounds |
| MX2020003811A (es) | 2017-10-05 | 2021-01-15 | Biogen Inc | Proceso para preparar derivados de alfa-carboxamida pirrolidina. |
| WO2019075073A2 (en) | 2017-10-10 | 2019-04-18 | Biogen Inc. | PROCESS FOR THE PREPARATION OF SPIRO DERIVATIVES |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94466A (en) | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| US6201016B1 (en) | 1994-06-27 | 2001-03-13 | Cytomed Incorporated | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| YU68701A (sh) | 1999-03-26 | 2004-09-03 | Euro-Celtique S.A. | Aril supstituisani pirazoli, imidazoli, oksazoli, tiazoli i piroli i njihova upotreba |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| TW200404796A (en) * | 2002-08-19 | 2004-04-01 | Ono Pharmaceutical Co | Nitrogen-containing compound |
| PA8583001A1 (es) * | 2002-09-20 | 2004-04-23 | Hoffmann La Roche | Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b |
| MY142651A (en) | 2003-03-18 | 2010-12-15 | Merck Sharp & Dohme | Biaryl substituted triazoles as sodium channel blockers |
| US7589116B2 (en) | 2003-04-03 | 2009-09-15 | Merck & Co. Inc. | Biaryl substituted pyrazoles as sodium channel blockers |
| AU2004232936B2 (en) | 2003-04-18 | 2008-10-30 | Merck & Co., Inc. | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
| WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
| US20060217365A1 (en) * | 2003-07-02 | 2006-09-28 | Astrazeneca Ab | Method of treating mood disorders |
| EP1524265A1 (en) * | 2003-10-15 | 2005-04-20 | Newron Pharmaceuticals S.p.A. | Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors |
| EP1877381A1 (en) | 2005-05-04 | 2008-01-16 | Vertex Pharmaceuticals Incorporated | Pyridines useful as modulators of ion channels |
| WO2006119451A1 (en) | 2005-05-04 | 2006-11-09 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyrazines useful as modulators of ion channels |
| JP2008540665A (ja) | 2005-05-19 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なビアリール |
| GB0701365D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0701366D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| CA2676357A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
| GB0706630D0 (en) | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
-
2006
- 2006-10-05 TW TW095136996A patent/TW200728258A/zh unknown
- 2006-10-06 EA EA200801068A patent/EA200801068A1/ru unknown
- 2006-10-06 US US11/570,564 patent/US7803833B2/en active Active
- 2006-10-06 AU AU2006301471A patent/AU2006301471A1/en not_active Abandoned
- 2006-10-06 PE PE2006001224A patent/PE20070495A1/es not_active Application Discontinuation
- 2006-10-06 BR BRPI0617189-3A patent/BRPI0617189A2/pt not_active IP Right Cessation
- 2006-10-06 JP JP2008534911A patent/JP5139306B2/ja not_active Expired - Fee Related
- 2006-10-06 NZ NZ567030A patent/NZ567030A/en unknown
- 2006-10-06 WO PCT/EP2006/009732 patent/WO2007042240A1/en not_active Ceased
- 2006-10-06 ES ES06806111T patent/ES2381686T3/es active Active
- 2006-10-06 EP EP06806111A patent/EP1934176B1/en active Active
- 2006-10-06 KR KR1020087011273A patent/KR20080059297A/ko not_active Withdrawn
- 2006-10-06 AT AT06806111T patent/ATE543797T1/de active
- 2006-10-06 CA CA002625763A patent/CA2625763A1/en not_active Abandoned
- 2006-10-09 AR ARP060104440A patent/AR057869A1/es active IP Right Grant
-
2008
- 2008-03-31 IL IL190544A patent/IL190544A/en active IP Right Grant
- 2008-04-25 CR CR9926A patent/CR9926A/es not_active Application Discontinuation
- 2008-05-06 NO NO20082122A patent/NO20082122L/no not_active Application Discontinuation
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2010
- 2010-08-04 US US12/850,330 patent/US8153623B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20100324022A1 (en) | 2010-12-23 |
| US8153623B2 (en) | 2012-04-10 |
| EP1934176A1 (en) | 2008-06-25 |
| NZ567030A (en) | 2011-03-31 |
| CR9926A (es) | 2008-07-29 |
| ATE543797T1 (de) | 2012-02-15 |
| US7803833B2 (en) | 2010-09-28 |
| EP1934176B1 (en) | 2012-02-01 |
| KR20080059297A (ko) | 2008-06-26 |
| TW200728258A (en) | 2007-08-01 |
| NO20082122L (no) | 2008-07-02 |
| AU2006301471A1 (en) | 2007-04-19 |
| WO2007042240A1 (en) | 2007-04-19 |
| AR057869A1 (es) | 2007-12-26 |
| US20080293753A1 (en) | 2008-11-27 |
| BRPI0617189A2 (pt) | 2011-07-19 |
| ES2381686T3 (es) | 2012-05-30 |
| IL190544A (en) | 2013-06-27 |
| JP2009514801A (ja) | 2009-04-09 |
| JP5139306B2 (ja) | 2013-02-06 |
| IL190544A0 (en) | 2008-11-03 |
| EA200801068A1 (ru) | 2009-02-27 |
| PE20070495A1 (es) | 2007-05-17 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |