CA2622684A1

CA2622684A1 - Systemes d'administration transdermique de medicament, dispositifs, et methodes faisant intervenir un agoniste opioide et/ou un antagoniste opioide

Systemes d'administration transdermique de medicament, dispositifs, et methodes faisant intervenir un agoniste opioide et/ou un antagoniste opioide Download PDF

Info

Publication number: CA2622684A1
Authority: CA; Canada
Prior art keywords: active agent; opioid antagonist; opioid; active; electrode assembly
Prior art date: 2005-09-30
Legal status : Abandoned

Application number

CA002622684A

Other languages

English (en)

Inventor

Darrick Carter

Current Assignee

TTI Ellebeau Inc

Original Assignee

Individual

Priority date

2005-09-30

Filing date

2006-09-29

Publication date

2007-04-12

2006-09-29 Application filed by Individual filed Critical Individual

2007-04-12 Publication of CA2622684A1 publication Critical patent/CA2622684A1/fr

Status Abandoned legal-status Critical Current

Links

239000003401 opiate antagonist Substances 0.000 title claims abstract description 66
238000000034 method Methods 0.000 title claims abstract description 57
239000003402 opiate agonist Substances 0.000 title claims abstract description 35
238000013271 transdermal drug delivery Methods 0.000 title description 7
239000013543 active substance Substances 0.000 claims abstract description 176
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 55
238000012377 drug delivery Methods 0.000 claims abstract description 20
230000001225 therapeutic effect Effects 0.000 claims abstract description 11
230000037317 transdermal delivery Effects 0.000 claims abstract description 7
239000003792 electrolyte Substances 0.000 claims description 48
208000002193 Pain Diseases 0.000 claims description 38
150000003839 salts Chemical class 0.000 claims description 37
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230000001939 inductive effect Effects 0.000 claims description 26
239000003795 chemical substances by application Substances 0.000 claims description 25
239000012453 solvate Substances 0.000 claims description 25
238000012384 transportation and delivery Methods 0.000 claims description 24
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WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims description 12
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108010093625 Opioid Peptides Proteins 0.000 claims description 5
102000001490 Opioid Peptides Human genes 0.000 claims description 5
BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 5
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PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims description 5
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JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims description 3
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APSUXPSYBJVPPS-YAUKWVCOSA-N Norbinaltorphimine Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CC=2C=3C[C@]4(O)[C@]67CCN(CC8CC8)[C@@H]4CC=4C7=C(C(=CC=4)O)O[C@H]6C=3NC=25)O)CC1)O)CC1CC1 APSUXPSYBJVPPS-YAUKWVCOSA-N 0.000 claims description 3
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APSUXPSYBJVPPS-YHMFJAFCSA-N ac1l3op1 Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CC=2C=3C[C@]4(O)[C@]67CCN(CC8CC8)[C@H]4CC=4C7=C(C(=CC=4)O)O[C@H]6C=3NC=25)O)CC1)O)CC1CC1 APSUXPSYBJVPPS-YHMFJAFCSA-N 0.000 claims description 3
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