CA2614880A1 - Vial - Google Patents
Vial Download PDFInfo
- Publication number
- CA2614880A1 CA2614880A1 CA002614880A CA2614880A CA2614880A1 CA 2614880 A1 CA2614880 A1 CA 2614880A1 CA 002614880 A CA002614880 A CA 002614880A CA 2614880 A CA2614880 A CA 2614880A CA 2614880 A1 CA2614880 A1 CA 2614880A1
- Authority
- CA
- Canada
- Prior art keywords
- vial
- vials
- bank
- selective
- reagent solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 claims abstract 24
- 238000011010 flushing procedure Methods 0.000 claims abstract 4
- 238000010926 purge Methods 0.000 claims 22
- 239000003153 chemical reaction reagent Substances 0.000 claims 20
- 239000002699 waste material Substances 0.000 claims 9
- 230000008878 coupling Effects 0.000 claims 6
- 238000010168 coupling process Methods 0.000 claims 6
- 238000005859 coupling reaction Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 4
- 239000000178 monomer Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 241000269627 Amphiuma means Species 0.000 claims 2
- 239000011343 solid material Substances 0.000 claims 2
- 230000000717 retained effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Landscapes
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
A vial is disclosed which may be used with a multi-wall loaded synthesizer. The vial comprises a bored interior having a consistent dimension to hold a frit for retaining material within the vial directly above the frit and maintain a consistent flow through the bored interior during a flushing procedure by only forming a pressure differential to expel material from the vial and a solid support retained within the vial above the frit after the flushing procedure.
Claims (34)
1. A synthesizer for forming a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:
a. a first vial and a second vial, wherein the first vial and the second vial are configured for holding the plurality of reagent solutions:
b. means for dispensing configured for dispensing the plurality of reagent solutions into the first and second vials; and c. means for selectively expelling material from the first and second vials.
configured for coupling to the first and second vials and purging material from a selective one of the first vial and the second vial.
a. a first vial and a second vial, wherein the first vial and the second vial are configured for holding the plurality of reagent solutions:
b. means for dispensing configured for dispensing the plurality of reagent solutions into the first and second vials; and c. means for selectively expelling material from the first and second vials.
configured for coupling to the first and second vials and purging material from a selective one of the first vial and the second vial.
2. The synthesizer according to claim 1 further comprising a cartridge configured for holding the first vial and the second vial.
3. The synthesizer according to claim 2 wherein the cartridge holds the first vial and the second vial along a circular perimeter of the cartridge.
4. The synthesizer according to claim 3 further comprising a motor coupled to the cartridge configured for selectively rotating the cartridge relative to the means for sequentially dispensing.
5. The synthesizer according to claim 4 further comprising a drain plate coupled to the cartridge for separating the first vial into a first bank of vials and the second vial into a second bank of vials.
6. The synthesizer according to claim 1 further comprising a chamber bowl coupled to the means for selectively expelling wherein the chamber bowl contains any spilled material.
7. The synthesizer according to claim 6 further comprising a seal coupled to the chamber bowl to prevent spilled material from escaping outside the chamber bowl.
8. The synthesizer according to claim 1 wherein the means for selectively expelling further comprises:
a. means for forming a pressure differential between a first opening and a second opening of the selective one of the first vial and the second vial; and b. a waste tube to collect material expelled from the selective one of the first vial and the second vial.
a. means for forming a pressure differential between a first opening and a second opening of the selective one of the first vial and the second vial; and b. a waste tube to collect material expelled from the selective one of the first vial and the second vial.
9. The synthesizer according to claim 1 wherein the means for dispensing further comprises:
a. a plurality of valves for controlling dispensing of the plurality of reagent solutions; and b. a plurality of dispense lines wherein each of the plurality of the dispense lines is coupled to a corresponding one of the plurality of valves for delivering one of the plurality of reagent solutions to a selected vial.
a. a plurality of valves for controlling dispensing of the plurality of reagent solutions; and b. a plurality of dispense lines wherein each of the plurality of the dispense lines is coupled to a corresponding one of the plurality of valves for delivering one of the plurality of reagent solutions to a selected vial.
10. The synthesizer according to claim 1 wherein each of the first vial and the second vial further comprise a precision bored interior configured to hold a frit for retaining a solid material above the frit, and further wherein the first vial and the second vial are configured to maintain a consistent flow through the precision bored interior.
11. A synthesizer for forming a polymer chain by sequentially adding monomer units found in a plurality of reagent solutions, the synthesizer comprising:
a. a first vial configured to hold the plurality of reagent solutions;
b. a second vial configured to hold the plurality of reagent solutions;
c. a cartridge to hold the first vial and the second vial:
d. a dispensing system to dispense the plurality of reagent solutions into the first and second vials; and e. a purging system to remove material from a selective one of the first vial and the second vial.
a. a first vial configured to hold the plurality of reagent solutions;
b. a second vial configured to hold the plurality of reagent solutions;
c. a cartridge to hold the first vial and the second vial:
d. a dispensing system to dispense the plurality of reagent solutions into the first and second vials; and e. a purging system to remove material from a selective one of the first vial and the second vial.
12. The synthesizer according to claim 11 wherein the cartridge holds the first vial and the second vial along a circular perimeter of the cartridge.
13. The synthesizer according to claim 11 further comprising a chamber bowl coupled to the purging system wherein the chamber bowl contains spilled material.
14. The synthesizer according to claim 13 further comprising a seal coupled to the chamber bowl to prevent spilled material from escaping outside the chamber bowl.
15. The synthesizer according to claim 11 wherein the purging system further comprises:
a. means for forming a pressure differential between a first opening and a second opening of the selective one of the first vial and the second vial; and b. a waste tube to collect material expelled from the selective one of the first vial and the second vial.
a. means for forming a pressure differential between a first opening and a second opening of the selective one of the first vial and the second vial; and b. a waste tube to collect material expelled from the selective one of the first vial and the second vial.
16. The synthesizer according to claim 11 wherein the dispensing system further comprises:
a. a plurality of valves for controlling dispensing of the plurality of reagent solutions; and b. a plurality of dispense lines each coupled to one of the plurality of valves for delivering a corresponding one of the reagent solutions to a selected vial.
a. a plurality of valves for controlling dispensing of the plurality of reagent solutions; and b. a plurality of dispense lines each coupled to one of the plurality of valves for delivering a corresponding one of the reagent solutions to a selected vial.
17. The synthesizer according to claim 11 wherein each of the first vial and the second vial further comprise a precision bored interior configured to hold a frit for retaining a solid material above the frit, and further wherein the first vial and the second vial are configured to maintain a consistent flow through the precision bored interior.
18. The synthesizer according to claim 11 further comprising a drain plate coupled to the cartridge for separating the first vial into a first bank of vials and the second vial into a second bank of vials.
19. The synthesizer according to claim 11 further comprising a motor coupled to the cartridge to selectively rotate the cartridge relative to the dispensing system.
20. A synthesizer for creating a polymer chain by sequentially adding monomer units found in one of a plurality of reagent solutions, the synthesizer comprising:
a. a plurality of vials wherein each of the plurality of vials is configured to hold material including the plurality of reagent solutions:
b. a cartridge for holding the plurality of vials and dividing the plurality of vials into a first bank of vials including at least one of the plurality of vials and a second bank of vials including at least one of the plurality of vials;
c. a dispensing system configured to sequentially dispense selective ones of the plurality of reagent solutions into the plurality of vials; and d. a purging system configured to selectively purge material from the first bank of vials and the second bank of vials.
a. a plurality of vials wherein each of the plurality of vials is configured to hold material including the plurality of reagent solutions:
b. a cartridge for holding the plurality of vials and dividing the plurality of vials into a first bank of vials including at least one of the plurality of vials and a second bank of vials including at least one of the plurality of vials;
c. a dispensing system configured to sequentially dispense selective ones of the plurality of reagent solutions into the plurality of vials; and d. a purging system configured to selectively purge material from the first bank of vials and the second bank of vials.
21. The synthesizer according to claim 20 further comprising a first drain coupled to the first bank of vials and a second drain coupled to the second bank of vials, the first and second drains each configured for selectively coupling with the purging system for draining the first bank of vials and the second bank of vials.
22. The synthesizer according to claim 21 wherein the purging system further comprises a waste tube capable of selectively coupling with a selective one of the first drain and the second drain to purge material from the first bank of vials and the second bank of vials.
23. The synthesizer according to claim 20 wherein the dispensing system further comprises:
a. a plurality of valves for controlling the dispensing of the plurality of reagent solutions; and b. a plurality of dispense lines each coupled to one of the plurality of valves for delivering a corresponding one of the plurality of reagent solutions to a selected vial.
a. a plurality of valves for controlling the dispensing of the plurality of reagent solutions; and b. a plurality of dispense lines each coupled to one of the plurality of valves for delivering a corresponding one of the plurality of reagent solutions to a selected vial.
24. A purging system configured for use with a synthesizer containing a first bank of vials and a second bank of vials wherein the first bank of vials has a first drain and the second bank of vials has a second drain, the purging system comprising:
a. a pressurizing system for creating a pressure differential within a selective one of the first bank of vials and the second bank of vials; and b. a first waste tube capable of coupling with a selective one of the first drain to purge material from the first bank of vials and the second drain to purge material from the second bank of vials.
a. a pressurizing system for creating a pressure differential within a selective one of the first bank of vials and the second bank of vials; and b. a first waste tube capable of coupling with a selective one of the first drain to purge material from the first bank of vials and the second drain to purge material from the second bank of vials.
25. The purging system according to claim 24 further comprising a drain seal coupled to the first waste tube for creating a flexible seal between the first waste tube and the selective one of the first drain and the second drain.
26. The purging system according to claim 24 further comprising a second waste tube capable of selectively coupling with the first drain to purge the material from the first bank of vials and the second drain to purge the material from the second bank of vials wherein the purging system is capable of selectively and simultaneously purging the first bank of vials and the second bank of vials.
27. A vial comprising a precision bored interior configured to hold a frit for retaining material within the vial above the frit and maintain a consistent flow through the precision bored interior during a flushing procedure.
28. The vial according to claim 27 further comprising an exterior dimension configured to fit within a receiving hole of a cartridge, thereby providing a pressure-tight seal between the vial and the cartridge.
29. A vial comprising an exterior dimension configured to fit within a receiving hole of a cartridge thereby providing a pressure-tight seal between the vial and the cartridge and a precision bored interior to maintain a consistent flow through the precision bored interior during a flushing procedure.
30. The vial according to claim 29 further comprising a frit positioned within the precision bored interior to retain material within the vial above the frit.
31. A method of selectively and sequentially dispensing a plurality of reagent solutions to a plurality of vials divided into a first bank of vials and a second bank of vials and selectively purging material from the first bank of vials and the second bank of vials, comprising the steps of:
a. dispensing one or more of the plurality of reagent solutions to a selective one or more of the plurality of vials; and b. purging material from a selective one of the first bank of vials and the second bank of vials.
a. dispensing one or more of the plurality of reagent solutions to a selective one or more of the plurality of vials; and b. purging material from a selective one of the first bank of vials and the second bank of vials.
32. The method according to claim 31 wherein during the step of dispensing one of the plurality of reagent solutions is dispensed into one or more of the plurality of vials in a parallel fashion.
33. The method according to claim 31 wherein during the step of dispensing one or more of the plurality of reagent solutions are dispensed into one or more of the plurality of vials in a serial fashion.
34. A method of selectively purging material from a selective one of a first vial and a second vial comprising the steps of:
a. coupling a waste tube to a selective one of a first drain corresponding to the first vial and a second drain corresponding to the second vial; and b. forming a pressure differential between an interior and an exterior of the selective one of the first vial and the second vial, thereby expelling material from the selective one of the first vial and the second vial through the waste tube.
a. coupling a waste tube to a selective one of a first drain corresponding to the first vial and a second drain corresponding to the second vial; and b. forming a pressure differential between an interior and an exterior of the selective one of the first vial and the second vial, thereby expelling material from the selective one of the first vial and the second vial through the waste tube.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/097,966 US6270730B1 (en) | 1998-06-16 | 1998-06-16 | Multi-well rotary synthesizer |
| US09/097,966 | 1998-06-16 | ||
| CA002331809A CA2331809C (en) | 1998-06-16 | 1999-06-15 | Multi-well rotary synthesizer |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002331809A Division CA2331809C (en) | 1998-06-16 | 1999-06-15 | Multi-well rotary synthesizer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2614880A1 true CA2614880A1 (en) | 1999-12-23 |
| CA2614880C CA2614880C (en) | 2012-08-21 |
Family
ID=39367233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2614880A Expired - Lifetime CA2614880C (en) | 1998-06-16 | 1999-06-15 | Vial |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2614880C (en) |
-
1999
- 1999-06-15 CA CA2614880A patent/CA2614880C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2614880C (en) | 2012-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20190617 |