CA2609000C - An implantable therapy system for treating a living being with an active factor - Google Patents
An implantable therapy system for treating a living being with an active factor Download PDFInfo
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- CA2609000C CA2609000C CA2609000A CA2609000A CA2609000C CA 2609000 C CA2609000 C CA 2609000C CA 2609000 A CA2609000 A CA 2609000A CA 2609000 A CA2609000 A CA 2609000A CA 2609000 C CA2609000 C CA 2609000C
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
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- Biomedical Technology (AREA)
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- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Prostheses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
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| DKPA200500723 | 2005-05-17 | ||
| DKPA200500723 | 2005-05-17 | ||
| DKPA200501668 | 2005-11-25 | ||
| DKPA200501668 | 2005-11-25 | ||
| PCT/DK2006/000261 WO2006122551A2 (en) | 2005-05-17 | 2006-05-15 | An implantable therapy system for treating a living being with an active factor |
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| CA2609000A1 CA2609000A1 (en) | 2006-11-23 |
| CA2609000C true CA2609000C (en) | 2015-01-13 |
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| CA2609000A Active CA2609000C (en) | 2005-05-17 | 2006-05-15 | An implantable therapy system for treating a living being with an active factor |
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| NZ (1) | NZ563313A (enExample) |
| WO (3) | WO2006122551A2 (enExample) |
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| AU2006246826B2 (en) | 2005-05-17 | 2011-01-06 | Gloriana Therapeutics Sarl | An implantable therapy system for treating a living being with an active factor |
| US8277903B2 (en) * | 2008-03-04 | 2012-10-02 | Academia Sinica | Synthesis and applications of soluble pentacene precursors and related compounds |
| WO2010083842A2 (en) | 2009-01-23 | 2010-07-29 | Nsgene A/S | Expression of neuropeptides in mammalian cells |
| EP2389435B1 (en) | 2009-01-23 | 2015-11-04 | NsGene A/S | Improved cell lines and their use in encapsulated cell biodelivery |
| US20120020931A1 (en) | 2010-06-02 | 2012-01-26 | Rutgers, The State University Of New Jersey | Therapeutic encapsulated embryonic stem cells and mesenchymal stromal cells |
| WO2011161666A2 (en) * | 2010-06-21 | 2011-12-29 | White Innovation Ltd. | Enclosed liquid capsules |
| WO2012041320A1 (en) | 2010-09-27 | 2012-04-05 | Nsgene A/S | Implantable cell device with supportive and radial diffusive scaffolding |
| KR101886029B1 (ko) | 2010-10-01 | 2018-08-07 | 호바 세라퓨틱스 에이피에스 | 무해자극통증, 통각과민증, 자발통증 및 헛통증의 치료를 위한 메테오린의 용도 |
| RU2761981C2 (ru) * | 2012-05-19 | 2021-12-14 | ТАРИС Биомедикал ЛЛК | Имплантируемое урологическое устройство с улучшенной характеристикой извлечения |
| EP3122884B1 (en) * | 2014-03-26 | 2019-12-25 | Tocagen Inc. | A retroviral vector having immune-stimulating activity |
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| US4695536A (en) | 1984-01-10 | 1987-09-22 | Lindstrom Richard L | Corneal storage system |
| US4844242A (en) * | 1987-09-02 | 1989-07-04 | The Johns Hopkins University | Cornea retainer |
| US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US5106627A (en) | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5487739A (en) * | 1987-11-17 | 1996-01-30 | Brown University Research Foundation | Implantable therapy systems and methods |
| US5773286A (en) * | 1987-11-17 | 1998-06-30 | Cytotherapeutics, Inc. | Inner supported biocompatible cell capsules |
| US5182111A (en) * | 1987-11-17 | 1993-01-26 | Boston University Research Foundation | In vivo delivery of active factors by co-cultured cell implants |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5786216A (en) | 1987-11-17 | 1998-07-28 | Cytotherapeutics, Inc. | Inner-supported, biocompatible cell capsules |
| US5156844A (en) | 1987-11-17 | 1992-10-20 | Brown University Research Foundation | Neurological therapy system |
| DE3829766A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Verfahren zur herstellung von membranen |
| DE3829752A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration |
| SG47470A1 (en) | 1991-04-25 | 1998-04-17 | Univ Brown Res Found | Implantable biocompatible immunoisolatory vehicle for delivery of a selected therapeutic products |
| US5512600A (en) | 1993-01-15 | 1996-04-30 | Massachusetts Institute Of Technology | Preparation of bonded fiber structures for cell implantation |
| JPH06210002A (ja) * | 1993-01-21 | 1994-08-02 | Nippon Zeon Co Ltd | 消化管用カテーテル |
| JPH09502620A (ja) * | 1993-06-23 | 1997-03-18 | ブラウン ユニヴァーシティ リサーチ ファンデーション | 移植可能な膜カプセル装置の密封方法及び装置 |
| AU7568094A (en) | 1993-08-12 | 1995-03-14 | Cytotherapeutics, Inc. | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| US5550050A (en) | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
| US5643286A (en) | 1994-06-24 | 1997-07-01 | Cytotherapeutics, Inc. | Microdrive for use in stereotactic surgery |
| US5853717A (en) | 1994-07-20 | 1998-12-29 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
| US5681740A (en) | 1995-06-05 | 1997-10-28 | Cytotherapeutics, Inc. | Apparatus and method for storage and transporation of bioartificial organs |
| US5904144A (en) * | 1996-03-22 | 1999-05-18 | Cytotherapeutics, Inc. | Method for treating ophthalmic diseases |
| US5725523A (en) * | 1996-03-29 | 1998-03-10 | Mueller; Richard L. | Lateral-and posterior-aspect method and apparatus for laser-assisted transmyocardial revascularization and other surgical applications |
| US6027721A (en) | 1996-05-20 | 2000-02-22 | Cytotherapeutics, Inc. | Device and method for encapsulated gene therapy |
| US6054142A (en) | 1996-08-01 | 2000-04-25 | Cyto Therapeutics, Inc. | Biocompatible devices with foam scaffolds |
| US6303136B1 (en) | 1998-04-13 | 2001-10-16 | Neurotech S.A. | Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane |
| US6361771B1 (en) * | 1999-04-06 | 2002-03-26 | Neurotech S.A. | ARPE-19 as a platform cell line for encapsulated cell-based delivery |
| AU2001296452A1 (en) * | 2000-10-02 | 2002-04-15 | Cryo-Cell International, Inc | Segmented vial assembly and related storage and retrieval method |
| SE0003672D0 (sv) * | 2000-10-12 | 2000-10-12 | Astrazeneca Ab | Package |
| EP1874392B1 (en) * | 2005-04-25 | 2012-05-16 | Cook Medical Technologies LLC | Object-delivery shuttle |
| AU2006246826B2 (en) | 2005-05-17 | 2011-01-06 | Gloriana Therapeutics Sarl | An implantable therapy system for treating a living being with an active factor |
-
2006
- 2006-05-15 AU AU2006246826A patent/AU2006246826B2/en not_active Ceased
- 2006-05-15 ES ES06722946.8T patent/ES2653844T3/es active Active
- 2006-05-15 NZ NZ563313A patent/NZ563313A/en not_active IP Right Cessation
- 2006-05-15 US US11/920,373 patent/US9364427B2/en not_active Expired - Fee Related
- 2006-05-15 EP EP06722946.8A patent/EP1883446B8/en active Active
- 2006-05-15 WO PCT/DK2006/000261 patent/WO2006122551A2/en not_active Ceased
- 2006-05-15 CA CA2609000A patent/CA2609000C/en active Active
- 2006-05-15 JP JP2008511552A patent/JP5010584B2/ja not_active Expired - Fee Related
- 2006-05-15 WO PCT/DK2006/000259 patent/WO2006122549A2/en not_active Ceased
- 2006-05-15 WO PCT/DK2006/000260 patent/WO2006122550A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1883446B1 (en) | 2017-09-06 |
| JP2008539996A (ja) | 2008-11-20 |
| WO2006122549A3 (en) | 2007-04-12 |
| WO2006122549A8 (en) | 2007-03-01 |
| US20090227978A1 (en) | 2009-09-10 |
| WO2006122551A2 (en) | 2006-11-23 |
| WO2006122550A3 (en) | 2007-04-12 |
| US9364427B2 (en) | 2016-06-14 |
| JP5010584B2 (ja) | 2012-08-29 |
| EP1883446B8 (en) | 2017-11-15 |
| NZ563313A (en) | 2010-01-29 |
| WO2006122550A2 (en) | 2006-11-23 |
| AU2006246826B2 (en) | 2011-01-06 |
| AU2006246826A1 (en) | 2006-11-23 |
| WO2006122551A8 (en) | 2007-05-24 |
| EP1883446A2 (en) | 2008-02-06 |
| ES2653844T3 (es) | 2018-02-09 |
| WO2006122549A2 (en) | 2006-11-23 |
| CA2609000A1 (en) | 2006-11-23 |
| WO2006122551A3 (en) | 2007-04-12 |
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