CA2601032A1 - 9-alkyladenines substituees et leur utilisation - Google Patents
9-alkyladenines substituees et leur utilisation Download PDFInfo
- Publication number
- CA2601032A1 CA2601032A1 CA002601032A CA2601032A CA2601032A1 CA 2601032 A1 CA2601032 A1 CA 2601032A1 CA 002601032 A CA002601032 A CA 002601032A CA 2601032 A CA2601032 A CA 2601032A CA 2601032 A1 CA2601032 A1 CA 2601032A1
- Authority
- CA
- Canada
- Prior art keywords
- methyladenine
- compound
- isopropylmethylamino
- endo
- norbornyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims abstract description 107
- 238000000034 method Methods 0.000 claims abstract description 31
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- 206010022562 Intermittent claudication Diseases 0.000 claims abstract description 5
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- 230000004217 heart function Effects 0.000 claims abstract description 5
- 208000021156 intermittent vascular claudication Diseases 0.000 claims abstract description 5
- 208000009304 Acute Kidney Injury Diseases 0.000 claims abstract description 4
- 208000033626 Renal failure acute Diseases 0.000 claims abstract description 4
- 201000011040 acute kidney failure Diseases 0.000 claims abstract description 4
- 208000012998 acute renal failure Diseases 0.000 claims abstract description 4
- 208000020832 chronic kidney disease Diseases 0.000 claims abstract description 4
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims abstract description 4
- 108010060263 Adenosine A1 Receptor Proteins 0.000 claims abstract 2
- 102000030814 Adenosine A1 receptor Human genes 0.000 claims abstract 2
- -1 cyano, methoxy, ethoxy, propoxy, thiomethyl Chemical group 0.000 claims description 25
- 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 claims description 19
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 125000000623 heterocyclic group Chemical group 0.000 claims description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
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- 150000002367 halogens Chemical class 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
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- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
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- 125000002636 imidazolinyl group Chemical group 0.000 claims description 5
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- LHUOCVFVYZUDEE-JOCQHMNTSA-N C=12N=C(C(C)C)N(C)C2=NC(NC)=NC=1N[C@H]1CC[C@H](OCCS(O)(=O)=O)CC1 Chemical compound C=12N=C(C(C)C)N(C)C2=NC(NC)=NC=1N[C@H]1CC[C@H](OCCS(O)(=O)=O)CC1 LHUOCVFVYZUDEE-JOCQHMNTSA-N 0.000 claims description 2
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66046605P | 2005-03-11 | 2005-03-11 | |
| US60/660,466 | 2005-03-11 | ||
| PCT/US2006/008715 WO2006099204A1 (fr) | 2005-03-11 | 2006-03-10 | 9-alkyladenines substituees et leur utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2601032A1 true CA2601032A1 (fr) | 2006-09-21 |
Family
ID=36589167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002601032A Abandoned CA2601032A1 (fr) | 2005-03-11 | 2006-03-10 | 9-alkyladenines substituees et leur utilisation |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080161327A1 (fr) |
| EP (1) | EP1863815A1 (fr) |
| JP (1) | JP2008534445A (fr) |
| CA (1) | CA2601032A1 (fr) |
| MX (1) | MX2007010984A (fr) |
| WO (1) | WO2006099204A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517888B2 (en) * | 2004-04-28 | 2009-04-14 | Cv Therapeutics, Inc. | A1 adenosine receptor antagonists |
| RU2661896C2 (ru) * | 2012-11-16 | 2018-07-23 | Мерк Шарп И Доум Корп. | Пуриновые ингибиторы фосфатидилинозитол-3-киназы дельта человека |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565566A (en) * | 1987-04-24 | 1996-10-15 | Discovery Therapeutics, Inc. | N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists |
| WO1990009178A1 (fr) * | 1989-01-31 | 1990-08-23 | Whitby Research, Inc. | 9-methyladenines substituees en position n6: une nouvelle classe d'antagonistes des recepteurs d'adenosine |
| US5208240A (en) * | 1991-03-12 | 1993-05-04 | Merrell Dow Pharmaceuticals Inc. | 8-substituted purines as selective adenosine receptor agents |
| US5670501A (en) * | 1994-09-01 | 1997-09-23 | Discovery Therapeutics, Inc. | N-substituted 9-alkyladenines |
| US5786360A (en) * | 1996-11-19 | 1998-07-28 | Link Technology Incorporated | A1 adenosine receptor antagonists |
| JP2002505687A (ja) * | 1997-06-18 | 2002-02-19 | ディスカバリー セラピューティクス，インコーポレイテッド | 脈管再生手順の後の再狭窄を防止するための組成物および方法 |
| HUP0400530A3 (en) * | 2000-12-01 | 2007-05-29 | Biogen Idec Inc | Condensed purine derivatives as a1 adenosine receptor antagonists |
| US6680324B2 (en) * | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US20050227933A1 (en) * | 2001-11-29 | 2005-10-13 | Benkovic Stephen J | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors |
-
2006
- 2006-03-10 US US11/886,086 patent/US20080161327A1/en not_active Abandoned
- 2006-03-10 JP JP2008500990A patent/JP2008534445A/ja not_active Withdrawn
- 2006-03-10 CA CA002601032A patent/CA2601032A1/fr not_active Abandoned
- 2006-03-10 WO PCT/US2006/008715 patent/WO2006099204A1/fr active Application Filing
- 2006-03-10 EP EP06737850A patent/EP1863815A1/fr not_active Withdrawn
- 2006-03-10 MX MX2007010984A patent/MX2007010984A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP1863815A1 (fr) | 2007-12-12 |
| JP2008534445A (ja) | 2008-08-28 |
| MX2007010984A (es) | 2008-03-18 |
| WO2006099204A1 (fr) | 2006-09-21 |
| US20080161327A1 (en) | 2008-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20131205 |