CA2599783A1 - Use of an antagonist of epac for treating human cardiac hypertrophy - Google Patents
Use of an antagonist of epac for treating human cardiac hypertrophy Download PDFInfo
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- CA2599783A1 CA2599783A1 CA002599783A CA2599783A CA2599783A1 CA 2599783 A1 CA2599783 A1 CA 2599783A1 CA 002599783 A CA002599783 A CA 002599783A CA 2599783 A CA2599783 A CA 2599783A CA 2599783 A1 CA2599783 A1 CA 2599783A1
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- 230000003827 upregulation Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65770705P | 2005-03-03 | 2005-03-03 | |
| US60/657,707 | 2005-03-03 | ||
| PCT/EP2006/001903 WO2006094703A1 (en) | 2005-03-03 | 2006-03-02 | Use of an antagonist of epac for treating human cardiac hypertrophy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2599783A1 true CA2599783A1 (en) | 2006-09-14 |
Family
ID=36283051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002599783A Abandoned CA2599783A1 (en) | 2005-03-03 | 2006-03-02 | Use of an antagonist of epac for treating human cardiac hypertrophy |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090169540A1 (enExample) |
| EP (1) | EP1853316A1 (enExample) |
| JP (1) | JP2008531631A (enExample) |
| CA (1) | CA2599783A1 (enExample) |
| WO (1) | WO2006094703A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007095278A2 (en) * | 2006-02-15 | 2007-08-23 | The Regents Of The University Of Michigan | Screening assays for antagonists and analyses of cardiac hypertrophy |
| GB0815315D0 (en) * | 2008-08-21 | 2008-09-24 | Univ Leiden | Organ protection |
| US20110060029A1 (en) * | 2009-04-08 | 2011-03-10 | Kosaku Iwatsubo | Method of treating cancer by modulating epac |
| CA2864356A1 (en) | 2012-02-10 | 2013-08-15 | The Board Of Regents Of The University Of Texas System | Modulators of exchange proteins directly activated by camp (epacs) |
| WO2014053315A1 (en) * | 2012-10-02 | 2014-04-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Tetrahydroquinoline derivatives and their use as epac inhibitors |
| US20170079970A1 (en) * | 2014-03-21 | 2017-03-23 | INSERM (Institut National de la Santé et de la Recherche Médicale | Tetrahydroquinoline derivatives and their use as epac1 inhibitors for the treatment of myocardial infarction injury |
| US9737512B2 (en) | 2015-03-11 | 2017-08-22 | The Board Of Regents Of The University Of Texas System | Methods and compositions for treating chronic pain |
| JP6978774B2 (ja) * | 2015-11-06 | 2021-12-08 | 国立大学法人 熊本大学 | 心不全の予防又は治療のための医薬組成物 |
| WO2020064597A1 (en) * | 2018-09-24 | 2020-04-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of epac1 activators for the treatment of chronic kidney diseases |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1107789T3 (da) * | 1998-08-24 | 2008-11-03 | Univ Leland Stanford Junior | Sammensætninger og metoder til beskyttelse af organer, væv og celler mod beskadigelse formidlet af immunsystemet |
| WO2000024768A2 (en) * | 1998-10-23 | 2000-05-04 | Massachusetts Institute Of Technology | Genes integrating signal transduction pathways |
-
2006
- 2006-03-02 US US11/885,452 patent/US20090169540A1/en not_active Abandoned
- 2006-03-02 JP JP2007557422A patent/JP2008531631A/ja not_active Withdrawn
- 2006-03-02 EP EP06707377A patent/EP1853316A1/en not_active Withdrawn
- 2006-03-02 WO PCT/EP2006/001903 patent/WO2006094703A1/en not_active Ceased
- 2006-03-02 CA CA002599783A patent/CA2599783A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090169540A1 (en) | 2009-07-02 |
| EP1853316A1 (en) | 2007-11-14 |
| WO2006094703A1 (en) | 2006-09-14 |
| JP2008531631A (ja) | 2008-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |