CA2593866C - Synthesis of peptide t-1249 using peptide intermediate fragments - Google Patents

Synthesis of peptide t-1249 using peptide intermediate fragments Download PDF

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Publication number
CA2593866C
CA2593866C CA2593866A CA2593866A CA2593866C CA 2593866 C CA2593866 C CA 2593866C CA 2593866 A CA2593866 A CA 2593866A CA 2593866 A CA2593866 A CA 2593866A CA 2593866 C CA2593866 C CA 2593866C
Authority
CA
Canada
Prior art keywords
peptide
charge
nmp
reactor
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2593866A
Other languages
English (en)
French (fr)
Other versions
CA2593866A1 (en
Inventor
Yeun-Kwei Han
L. Mark Hodges
David A. Johnston
Hiralal N. Khatri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2593866A1 publication Critical patent/CA2593866A1/en
Application granted granted Critical
Publication of CA2593866C publication Critical patent/CA2593866C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2593866A 2004-12-30 2005-12-22 Synthesis of peptide t-1249 using peptide intermediate fragments Expired - Fee Related CA2593866C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64071604P 2004-12-30 2004-12-30
US60/640,716 2004-12-30
PCT/EP2005/013854 WO2006069729A1 (en) 2004-12-30 2005-12-22 Synthesis of peptide t-1249 using peptide intermediate fragments

Publications (2)

Publication Number Publication Date
CA2593866A1 CA2593866A1 (en) 2006-07-06
CA2593866C true CA2593866C (en) 2013-08-06

Family

ID=36001047

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2593866A Expired - Fee Related CA2593866C (en) 2004-12-30 2005-12-22 Synthesis of peptide t-1249 using peptide intermediate fragments

Country Status (9)

Country Link
US (1) US7544665B2 (https=)
EP (1) EP1856142B1 (https=)
JP (1) JP4886703B2 (https=)
CN (1) CN101133076B (https=)
AT (1) ATE439371T1 (https=)
CA (1) CA2593866C (https=)
DE (1) DE602005016024D1 (https=)
ES (1) ES2329270T3 (https=)
WO (1) WO2006069729A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4886702B2 (ja) * 2004-12-30 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー ペプチド中間体断片を使用するペプチドｔ−２０の合成
JP5473925B2 (ja) * 2007-10-27 2014-04-16 コーデン ファーマ コロラド インコーポレイテッド 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成
BRPI0820765A2 (pt) * 2007-12-11 2015-06-16 Hoffmann La Roche Métodos para a produção de um peptídeo insulinotrópico e peptídeos
DE102008017645A1 (de) 2008-04-04 2009-10-08 Carl Zeiss Smt Ag Vorrichtung zur mikrolithographischen Projektionsbelichtung sowie Vorrichtung zur Inspektion einer Oberfläche eines Substrats

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4010560B2 (ja) * 1992-07-20 2007-11-21 ドューク ユニバーシティー Ｈｉｖ複製を阻害する化合物
US6281335B1 (en) * 1993-10-08 2001-08-28 Coulter Corporation Hybridoma and anti-KC-4 humanized monoclonal antibody
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
US20040209999A1 (en) * 2002-08-16 2004-10-21 Bohling James Charles Method of manufacturing polypeptides, including T-20 and T-1249, at commercial scale, and polypeptide compositions related thereto
AU2004200485A1 (en) * 2003-02-25 2004-09-09 Rohm And Haas Company Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto
JP4886702B2 (ja) * 2004-12-30 2012-02-29 エフ．ホフマン−ラ ロシュ アーゲー ペプチド中間体断片を使用するペプチドｔ−２０の合成

Also Published As

Publication number Publication date
WO2006069729A1 (en) 2006-07-06
CA2593866A1 (en) 2006-07-06
JP4886703B2 (ja) 2012-02-29
ATE439371T1 (de) 2009-08-15
EP1856142B1 (en) 2009-08-12
CN101133076A (zh) 2008-02-27
EP1856142A1 (en) 2007-11-21
JP2008526699A (ja) 2008-07-24
US7544665B2 (en) 2009-06-09
US20060173163A1 (en) 2006-08-03
ES2329270T3 (es) 2009-11-24
DE602005016024D1 (de) 2009-09-24
CN101133076B (zh) 2011-07-13

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Legal Events

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MKLA Lapsed

Effective date: 20171222