CA2591467A1 - Transfer device for fluids - Google Patents

Transfer device for fluids Download PDF

Info

Publication number
CA2591467A1
CA2591467A1 CA002591467A CA2591467A CA2591467A1 CA 2591467 A1 CA2591467 A1 CA 2591467A1 CA 002591467 A CA002591467 A CA 002591467A CA 2591467 A CA2591467 A CA 2591467A CA 2591467 A1 CA2591467 A1 CA 2591467A1
Authority
CA
Canada
Prior art keywords
container
cartridge
transfer device
cap
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002591467A
Other languages
French (fr)
Inventor
David L. Reynolds
Daniel Macdonald
Julie Trepanier
Steve Raymond
Caroline Lavoie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duoject Medical Systems Inc
Original Assignee
Duoject Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duoject Medical Systems Inc filed Critical Duoject Medical Systems Inc
Priority to CA002591467A priority Critical patent/CA2591467A1/en
Priority to PCT/CA2008/001125 priority patent/WO2008151431A1/en
Priority to EP08772788A priority patent/EP2175824A4/en
Priority to AU2008261517A priority patent/AU2008261517A1/en
Priority to US12/157,867 priority patent/US8088118B2/en
Priority to CA2687962A priority patent/CA2687962C/en
Priority to JP2010511458A priority patent/JP2010528789A/en
Publication of CA2591467A1 publication Critical patent/CA2591467A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/1406Septums, pierceable membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2013Piercing means having two piercing ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2065Connecting means having aligning and guiding means

Description

TRANSFER DEVICE FOR FLUIDS
FIELD OF THE INVENTION

The present invention relates to a transfer device and more particularly, relates to a transfer device suitable for transferring fluid contents from a first cartridge to a second container.

BACKGROUND OF THE INVENTION

In the pharmaceutical field, medicants can be packaged in a first type of container and need to be transferred to a second type of container. The reason could be that the second type of container is a specialized one which is difficult to fill on known production lines. A second situation can arise when it is desired to transfer a fluid into a second container which may contain a second drug component which is to be mixed with the first fluid. In this regard, reference may be had to PCT Application CA2005/001839, the teachings of which are hereby incorporated by reference.

SUMMARY OF THE INVENTION

It is an object of the present invention to provide a transfer device for transferring fluid from a cartridge or a first container to a second container in a sterile environment. As used herein, the term fluid includes any substance having a liquid component thereof including, for example, suspensions, solutions, emulsions, etc.

The transfer device also preferably includes means for ejecting the filled container therefrom.

BRIEF DESCRIPTION OF THE DRAWINGS

Having thus generally described the invention, reference will be made to the accompanying drawings illustrating embodiments thereof, in which:

Figure 1 is a schematic side sectional view of a transfer device according to one embodiment of the present invention;

Figures 2A, 2B and 2C are views similar to Figure 1 illustrating the sequential operation for the venting of the container to be filled;

Figure 3 is a similar view showing the indexing of the cap;

Figures 4A and 4B are similar views illustrating transfer of the fluid from the cartridge to the container.

Figure 5 is an exploded view of a further embodiment of a further embodiment of a transfer device according to an embodiment of the present invention;

Figure 6A is a perspective view of the transfer device of Figure 5 illustrating the initial movement and venting of the container;

Figure 6B is a first side sectional view thereof;
Figure 6C is a second side elevational view thereof;

Figure 7A is a perspective view showing puncturing of the container;
Figures 7B and 7C are side sectional views thereof;

Figure 8A is a perspective view showing puncturing of the cartridge;
Figures 8B and 8C are side sectional views thereof;

Figure 9A is a perspective view showing the commencement of the transfer of the fluid from the cartridge to the container;

Figures 9B and 9C are side sectional views thereof;

Figure l 0A is a perspective view of the transfer device following transfer of the fluid;
Figures lOB and lOC are side sectional views thereof;

Figure 11A is a perspective view showing the ejection of the container from the
-2-transfer device; and Figures 11B and 11C are side sectional views thereof. -DETAILED DESCRIPTION OF THE INVENTION

Referring to the drawings in greater detail and by reference characters thereto, there is illustrated in Figure 1 a transfer device generally designated by reference numeral 10.
Transfer device 10 includes a conventional fluid containing cartridge 12, a container 14 to which the fluid is to be transferred, and a shuttle 16.

Cartridge 12 has a cylindrical body 20 and may be of any suitable dimensions though in the illustrated embodiment, it is of an elongated configuration with a plunger 22 being located at one end thereof. At the other end, there is provided a pierceable cap 24 while the cylindrical body 20 contains a fluid 26 to be transferred to container 14.

Container 14, to which the fluid is to be transferred, has an outer wall 28 defining the container with a pierceable plunger 30 located at one end thereof. A proboscis 32 is located at the other end.

Shuttle 16 includes a main body portion 36 with legs 38 extending from one end thereof. In the illustrated embodiment, there are provided two such legs 38.
Each leg 38 has at an end thereof a flange 40 extending diagonally outwardly.

Extending through main body 36 is a cannula which has a first piercing tip 44 located at one end thereof and a second piercing tip 46 located at the other end thereof.

Transfer device 10 also includes an outer housing 50. On the interior wall of housing 50 there is provided a first shoulder 52 which has a substantial length for reasons which will be discussed hereinbelow. A second shorter shoulder 54 is provided on the other side thereof. It will also be seen that outer housing 50 has an inwardly extending portion 56
-3-located on an inner wall thereof, again for reasons which will be discussed hereinbelow.
A pusher mechanism generally designated by reference numeral 60 includes a centrally located plunger rod 62 and an end cap 64 at one end thereof. A
second outer pusher element 66 extends parallel to and spaced from plunger rod 62 and terminates in an inwardly extending flange 70. It will be noted that outer pusher element 66 has a protrusion 68 extending outwardly therefrom. End cap 64 also has a second end flange 72.
Transfer device 10 also includes a cap 76 having a top wall 78 and a side wall 80 and which cap 76 extends over the end of housing 50. A stopper 82 extends inwardly from side wall 80.

In use, and as shown in Figure 1, cartridge 12 is placed interiorly of housing 50.
Subsequently, and as shown in Figures 2A, 2B and 2C, container 14 is vented.
To accomplish the venting, pusher mechanism 60 is continually pushed as indicated by arrows 84. The initial pushing causes end flange 70 to engage the end of cylindrical body 20 and exert pressure thereon. Cartridge 12 is then urged into a position wherein flanges 40 on legs 38 of shuttle 16 engage a shoulder portion of cartridge 12. A flange 40 also engages shoulder 52 to prevent outer movement thereof. This causes shuttle 16 to move to a position wherein first piercing tip 44 of cannula 42 pierces plunger 30 of container 14. A subsequent movement, as indicated by arrow 84 and as shown in Figure 2A, causes plunger 30 to move towards its upper end. Air from container 14 is vented through cannula 42.

As may be seen in Figures 2B and 2C, when plunger 30 is at the upper end of container 14, further movement is not possible. However, at the same time, legs 38 and flanges 40 have passed by shoulders 52 and 54 thereby permitting outward movement of the legs 38. Second piercing tip 46 will then pierce the pierceable cap 24 on cartridge 12 as
-4-seen in Figure 2C.

Subsequently, cap 76 is rotated as shown in Figure 3 by arrow 86. Stopper 82 is then no longer engaging proboscis 32 and this permits the upward movement of container 14, shuttle 16, cartridge 12 and pusher mechanism 60 to the position shown in Figure 4A. At this point in time, protrusion 68 on outer pusher element 66 will engage inwardly extending protrusion 56. This will cause the outer flexing of end flange 70 such that it will extend outwardly of cartridge 12 and no longer be in a position to push cartridge 12 upwardly. At this point in time, plunger rod 62 will contact plunger 22 to thereby put pressure on fluid 34 and force the same through cannula 42 into container 14 as may be seen in Figure 4B. As may also be seen in Figure 4B, shoulders 52 and 54 will prevent pusher mechanism 60 from going past a certain point.

Subsequently, cap 76 may be removed to permit access to container 14.

It will be understood that many different configurations of cartridge 12 and container 14 may be utilized.

Referring to the embodiment of Figures 5 to 11, a second type of transfer device is generally designated by reference numeral I 10.

Transfer device 110, as may be best seen in Figure 5, comprises a pusher mechanism generally designated by reference numeral 112, a cartridge holder generally designated by reference numeral 114 and a cartridge generally designated by reference numeral 116.

There is also provided a needle assembly generally designated by reference numeral 118, a shuttle 120, an ejector 122, a container holder 124, a container 126 and a cap 128.

Pusher mechanism 112 includes a plunger rod 132 secured to an end cap 134.
-5-Extending parallel to plunger rod 132 from end cap 134 are a pair of legs 136 which are spaced exteriorly of plunger rod 132. On legs 136, there are provided interiorly extending protrusions 138 and exteriorly extending protrusions 140.

Cartridge holder 114 is designed to receive a standard fluid containing medical cartridge (in this particular case a 3 ml cartridge) and comprises a side wall 144 with a base 146 being spaced inwardly from the bottom of side wall 144. At its upper end, legs 148 are provided with an enlarged portion which terminates in a sloped ramp segment 152 for reasons which will become apparent hereinbelow.

Cartridge 116, as aforementioned, is a standard cartridge such as used in the pharmaceutical industry and comprises a cylindrical body 156 with a plunger 158 located at the bottom thereof. At the upper end, cartridge 116 is provided with a pierceable cap 160.
Interiorly of cylindrical body 158, there is a fluid 162 which is to be transferred to container 126. Again, fluid 162 may be any conventional fluid such as a liquid, suspension, solution, emulsion, etc.

Needle assembly 118 includes a needle hub 164, an upper needle sheath 166, and a lower needle sheath 168. Needle hub 164 retains a cannula having an upper piercing tip 172 and a lower piercing tip 174.

Shuttle 120 has a lower body portion 178 which has an inverted U-shaped slot formed on opposite sides of lower body portion 178 for reasons which will be discussed hereinbelow. Lower body portion 178 is somewhat oval in cross-section and includes a pair of side walls 182. Shuttle 120 has an interior transverse wall 184. Interior transverse wall 184 serves to mount levers 186 on either side of the shuttle 120. Each lever 186 has an upper inner
-6-protrusion 189 having a sloped ramp segment 191 while having a lower outwardly extending protrusion 190 also with a sloped ramp segment 192. An upper body portion 194 of shuttle 120 has a slot 196 formed therein and as well, at the upper end, includes inwardly extending protrusions 198.

Ejector 122 comprises a coil spring 200.

Container holder 124 has a lower cylindrical body portion 204 which has a flange 206 at the upper end thereof extending outwardly. A base 208 is located at the bottom of lower body portion 204. Lower body portion 204 is defined by a side wa11210.

Extending upwardly from lower body portion 204 is an upper wall segment 212 which, at its upper end, has a horizontal wall segment 214 and an upper wall segment 216.
Tongues 218 extend inwardly from upper wall segment 216.

Container 126 has a main body portion 222 and a proboscis 224 extending from an upper wall thereof. Proboscis 224, on at least one side thereof, is formed of a resealable material which can be pierced by a needle and once the needle is withdrawn, seal itself.
Such materials are well known in the pharmaceutical industry. A pierceable resealable sea1223 closes the bottom of container 126.

Cap 128, which is best seen in Figures 6A to 6C, includes a side wa11228 and a top wa11230. There is an opening in side wa11228 and an interior structure including grooves (not shown) to permit movement along tongues 218 of container holder 124.
Mounted interiorly of a cap 128 is a venting needle 226 which is designed to pierce proboscis 224 to permit venting through needle 232. A hydrophobic filter 234 is provided to permit air to pass therethrough while preventing the passage of any liquid.

Referring initially to Figures 6A to 6C, as indicated by arrow 236, cap 128 is slid into
-7-a position such that needle 226 will pierce proboscis 224 to permit venting of the interior of container 126.

Subsequently, as indicated by arrow 238, pressure is applied to legs 136 followed by upward movement of pusher mechanism 112 as indicated by arrow 240 in Figure 7A.

This upward movement will cause cartridge holder 114 to move upwardly. In so doing, and as may be seen in Figures 7B, 7C, 8B and 8C, enlarged portion 150 of legs 148, due to the sloped ramp segment 152, moves inwardly from a recess 195 in lower body portion 178 as indicated by arrows 242. Thus, the wall of shuttle 120 will flex outwardly due to U-shaped cut 180 to permit passage of enlarged portion 150. As a result, needle hub 164 moves upwardly and upper piercing tip 172 of cannula 170 will pierce seal 223 of container 126.

Enlarged portions 150 then enter the space between the lower portion of lever and a central body portion of shuttle 120. In so doing, they then exert an outwardly extending pressure on the lower part of lever 186 as indicated by arrows 244.
Further movement will result in the lower piercing tip 174 entering into pierceable cap 160 of cartridge 116 as shown in Figures 9B and 9C.

After the piercing of pierceable cap 160, pressure on the legs 136 is released as indicated by arrows 246 in Figure 9A. Continued upward pressure as indicated by arrow 240 will then cause engagement of plunger rod 132 with plunger 158 to exert pressure on the fluid 162 and transfer the same through cannula 170 into the interior of cartridge 116.
As may be seen in Figures 10A, lOB and IOC, legs 136 of pusher mechanism 112 will then engage the lower outer protrusions 190 and in particular the sloped ramp segment 192 to cause the lower end of lever 186 to move inwardly. This inward movement,
-8-as indicated by arrow 248 will then cause the outward movement of the upper portion of lever 186 as indicated by arrow 250. This movement releases the engagement of upper inner protrusion 188 with the flange 206 of lower body portion 204 of cartridge holder 114.

As a result of the above, coil spring 200 exerts an upward pressure on container holder 124 such that when cap 128 is removed as shown in Figures 11 A, 11 B
and 11 C, the container holder 124 is moved upwardly such that access may be had to the container 126.

It will be understood that the above described embodiments are for purposes of illustration only and that changes and modifications may be made thereto without departing from the spirit and scope of the invention.
-9-

Claims

CA002591467A 2007-06-13 2007-06-13 Transfer device for fluids Abandoned CA2591467A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002591467A CA2591467A1 (en) 2007-06-13 2007-06-13 Transfer device for fluids
PCT/CA2008/001125 WO2008151431A1 (en) 2007-06-13 2008-06-13 Device for transferring fluids from a cartridge to a container
EP08772788A EP2175824A4 (en) 2007-06-13 2008-06-13 Device for transferring fluids from a cartridge to a container
AU2008261517A AU2008261517A1 (en) 2007-06-13 2008-06-13 Device for transferring fluids from a cartridge to a container
US12/157,867 US8088118B2 (en) 2007-06-13 2008-06-13 Device for transferring fluid from a cartridge to a container
CA2687962A CA2687962C (en) 2007-06-13 2008-06-13 Device for transferring fluids from a cartridge to a container
JP2010511458A JP2010528789A (en) 2007-06-13 2008-06-13 Device for transferring liquid from cartridge to container

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002591467A CA2591467A1 (en) 2007-06-13 2007-06-13 Transfer device for fluids

Publications (1)

Publication Number Publication Date
CA2591467A1 true CA2591467A1 (en) 2008-12-13

Family

ID=40120370

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002591467A Abandoned CA2591467A1 (en) 2007-06-13 2007-06-13 Transfer device for fluids

Country Status (1)

Country Link
CA (1) CA2591467A1 (en)

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