CA2583253A1 - Difluoro-substituted imidazopyridines - Google Patents
Difluoro-substituted imidazopyridines Download PDFInfo
- Publication number
- CA2583253A1 CA2583253A1 CA002583253A CA2583253A CA2583253A1 CA 2583253 A1 CA2583253 A1 CA 2583253A1 CA 002583253 A CA002583253 A CA 002583253A CA 2583253 A CA2583253 A CA 2583253A CA 2583253 A1 CA2583253 A1 CA 2583253A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- fluoro
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- -1 Difluoro-substituted imidazopyridines Chemical class 0.000 title claims description 59
- 150000001875 compounds Chemical class 0.000 claims abstract description 125
- 229910052739 hydrogen Inorganic materials 0.000 claims description 168
- 239000001257 hydrogen Substances 0.000 claims description 164
- 150000002431 hydrogen Chemical group 0.000 claims description 131
- 229910052736 halogen Inorganic materials 0.000 claims description 56
- 150000002367 halogens Chemical group 0.000 claims description 56
- 150000003839 salts Chemical class 0.000 claims description 45
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 32
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 18
- 239000003814 drug Substances 0.000 claims description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- 229910052757 nitrogen Inorganic materials 0.000 claims description 13
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 13
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 2
- 230000028327 secretion Effects 0.000 abstract description 3
- 210000004211 gastric acid Anatomy 0.000 abstract description 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 82
- 235000013350 formula milk Nutrition 0.000 description 50
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 34
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 33
- 239000000047 product Substances 0.000 description 20
- 239000000243 solution Substances 0.000 description 19
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
- 239000012044 organic layer Substances 0.000 description 13
- 239000002253 acid Substances 0.000 description 11
- 238000002844 melting Methods 0.000 description 11
- 230000008018 melting Effects 0.000 description 11
- 238000004440 column chromatography Methods 0.000 description 10
- CSJLBAMHHLJAAS-UHFFFAOYSA-N diethylaminosulfur trifluoride Chemical compound CCN(CC)S(F)(F)F CSJLBAMHHLJAAS-UHFFFAOYSA-N 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 239000012043 crude product Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 9
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000003682 fluorination reaction Methods 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 5
- 238000001212 derivatisation Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- APOYTRAZFJURPB-UHFFFAOYSA-N 2-methoxy-n-(2-methoxyethyl)-n-(trifluoro-$l^{4}-sulfanyl)ethanamine Chemical compound COCCN(S(F)(F)F)CCOC APOYTRAZFJURPB-UHFFFAOYSA-N 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical class [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
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- 241000700159 Rattus Species 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 230000009858 acid secretion Effects 0.000 description 3
- 239000005557 antagonist Substances 0.000 description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 125000001153 fluoro group Chemical group F* 0.000 description 3
- 230000027119 gastric acid secretion Effects 0.000 description 3
- VPUDIWIKGNMSOL-UHFFFAOYSA-N imidazo[1,2-a]pyridin-8-ol Chemical compound OC1=CC=CN2C=CN=C12 VPUDIWIKGNMSOL-UHFFFAOYSA-N 0.000 description 3
- 150000005232 imidazopyridines Chemical class 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- ANRIQLNBZQLTFV-DZUOILHNSA-N pentagastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1[C]2C=CC=CC2=NC=1)NC(=O)CCNC(=O)OC(C)(C)C)CCSC)C(N)=O)C1=CC=CC=C1 ANRIQLNBZQLTFV-DZUOILHNSA-N 0.000 description 3
- 229960000444 pentagastrin Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000012312 sodium hydride Substances 0.000 description 3
- 229910000104 sodium hydride Inorganic materials 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
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- 239000007858 starting material Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 description 2
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 241000590002 Helicobacter pylori Species 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
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- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 description 2
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
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- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 description 1
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- BZGIPVGCJGXQTA-UHFFFAOYSA-N s-[2-(diethylamino)ethyl] n,n-diphenylcarbamothioate Chemical compound C=1C=CC=CC=1N(C(=O)SCCN(CC)CC)C1=CC=CC=C1 BZGIPVGCJGXQTA-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04105095 | 2004-10-15 | ||
| EP04105095.6 | 2004-10-15 | ||
| PCT/EP2005/055223 WO2006040338A1 (en) | 2004-10-15 | 2005-10-13 | Difluoro-substituted imidazopyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2583253A1 true CA2583253A1 (en) | 2007-04-05 |
Family
ID=34929711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002583253A Abandoned CA2583253A1 (en) | 2004-10-15 | 2005-10-13 | Difluoro-substituted imidazopyridines |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20080114020A1 (en10) |
| EP (1) | EP1802629A1 (en10) |
| JP (1) | JP2008516927A (en10) |
| KR (1) | KR20070084034A (en10) |
| CN (1) | CN101035793A (en10) |
| AR (1) | AR051375A1 (en10) |
| AU (1) | AU2005293576A1 (en10) |
| BR (1) | BRPI0516848A (en10) |
| CA (1) | CA2583253A1 (en10) |
| EA (1) | EA200700768A1 (en10) |
| IL (1) | IL181838A0 (en10) |
| MX (1) | MX2007004022A (en10) |
| NO (1) | NO20072340L (en10) |
| TW (1) | TW200630373A (en10) |
| WO (1) | WO2006040338A1 (en10) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011004882A1 (ja) | 2009-07-09 | 2011-01-13 | ラクオリア創薬株式会社 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4468400A (en) * | 1982-12-20 | 1984-08-28 | Schering Corporation | Antiulcer tricyclic imidazo [1,2-a]pyridines |
| MXPA03003706A (es) * | 2000-10-25 | 2005-01-25 | Altana Pharma Ag | Imidazopiridinas polisustituidas, como inhibidores de secrecion gastrica. |
| TWI295575B (en) * | 2002-04-24 | 2008-04-11 | Altana Pharma Ag | Nitrosated imidazopyridines |
-
2005
- 2005-09-26 AR ARP050103984A patent/AR051375A1/es unknown
- 2005-10-13 JP JP2007536176A patent/JP2008516927A/ja active Pending
- 2005-10-13 EA EA200700768A patent/EA200700768A1/ru unknown
- 2005-10-13 CA CA002583253A patent/CA2583253A1/en not_active Abandoned
- 2005-10-13 WO PCT/EP2005/055223 patent/WO2006040338A1/en active Application Filing
- 2005-10-13 AU AU2005293576A patent/AU2005293576A1/en not_active Abandoned
- 2005-10-13 MX MX2007004022A patent/MX2007004022A/es not_active Application Discontinuation
- 2005-10-13 KR KR1020077010350A patent/KR20070084034A/ko not_active Application Discontinuation
- 2005-10-13 BR BRPI0516848-1A patent/BRPI0516848A/pt not_active Application Discontinuation
- 2005-10-13 CN CNA2005800335076A patent/CN101035793A/zh active Pending
- 2005-10-13 EP EP05801525A patent/EP1802629A1/en not_active Withdrawn
- 2005-10-13 US US11/663,925 patent/US20080114020A1/en not_active Abandoned
- 2005-10-14 TW TW094135927A patent/TW200630373A/zh unknown
-
2007
- 2007-03-11 IL IL181838A patent/IL181838A0/en unknown
- 2007-05-07 NO NO20072340A patent/NO20072340L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007004022A (es) | 2007-05-24 |
| TW200630373A (en) | 2006-09-01 |
| BRPI0516848A (pt) | 2008-09-23 |
| JP2008516927A (ja) | 2008-05-22 |
| CN101035793A (zh) | 2007-09-12 |
| WO2006040338A1 (en) | 2006-04-20 |
| AU2005293576A1 (en) | 2006-04-20 |
| EA200700768A1 (ru) | 2007-10-26 |
| AR051375A1 (es) | 2007-01-10 |
| US20080114020A1 (en) | 2008-05-15 |
| IL181838A0 (en) | 2007-07-04 |
| EP1802629A1 (en) | 2007-07-04 |
| KR20070084034A (ko) | 2007-08-24 |
| NO20072340L (no) | 2007-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |