CA2577288C - Chlorhydrate de 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile - Google Patents

Chlorhydrate de 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile Download PDF

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Publication number
CA2577288C
CA2577288C CA2577288A CA2577288A CA2577288C CA 2577288 C CA2577288 C CA 2577288C CA 2577288 A CA2577288 A CA 2577288A CA 2577288 A CA2577288 A CA 2577288A CA 2577288 C CA2577288 C CA 2577288C
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Canada
Prior art keywords
pharmaceutical composition
compound
composition according
formula
tablet
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Active
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CA2577288A
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English (en)
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CA2577288A1 (fr
Inventor
Paul Theodoor Agnes Stevens
Jozef Peeters
Roger Petrus Gerebern Vandecruys
Alfred Elisabeth Stappers
Alex Herman Copmans
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34940340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2577288(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from MYPI20043578A external-priority patent/MY169670A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CA2577288A1 publication Critical patent/CA2577288A1/fr
Application granted granted Critical
Publication of CA2577288C publication Critical patent/CA2577288C/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Abstract

L'invention concerne une composition pharmaceutique comprenant, en tant que principe actif, le sel d'acide chlorhydrique de 4-[[4-[[4-(2-cyanoéthényl)-2,6-diméthyl-phényl]amino]-2-pyrimidinyl]amino] benzonitrile ainsi que des procédés de préparation de ladite composition.
CA2577288A 2004-09-02 2005-09-02 Chlorhydrate de 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile Active CA2577288C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
MYPI20043578A MY169670A (en) 2003-09-03 2004-09-02 Combinations of a pyrimidine containing nnrti with rt inhibitors
MYPI20043578 2004-09-02
EPPCT/EP2004/052028 2004-09-03
PCT/EP2004/052028 WO2005021001A1 (fr) 2003-09-03 2004-09-03 Combinaisons d'une pyrimidine renfermant nnrti avec des inhibiteurs de rt
EP05101467.8 2005-02-25
EP05101467 2005-02-25
PCT/EP2005/054342 WO2006024668A1 (fr) 2004-09-02 2005-09-02 Chlorhydrate de 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile

Publications (2)

Publication Number Publication Date
CA2577288A1 CA2577288A1 (fr) 2006-03-09
CA2577288C true CA2577288C (fr) 2010-11-30

Family

ID=34940340

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2577288A Active CA2577288C (fr) 2004-09-02 2005-09-02 Chlorhydrate de 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile

Country Status (5)

Country Link
KR (1) KR101284361B1 (fr)
AU (1) AU2005279158C1 (fr)
CA (1) CA2577288C (fr)
PL (1) PL1632232T6 (fr)
WO (1) WO2006024668A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
RS52821B2 (sr) * 2006-01-20 2021-07-30 Janssen Sciences Ireland Unlimited Co Dugotrajno tretiranje hiv-infekcije sa tcm278
AR065720A1 (es) 2007-03-14 2009-06-24 Tibotec Pharm Ltd Polvos para reconstitucion que comprenden rilpivirina dispersos en ciertos polimeros. uso. proceso.
KR101017862B1 (ko) * 2007-06-08 2011-03-04 베링거 인겔하임 인터내셔날 게엠베하 네비라핀의 서방성 제형
US8426434B2 (en) 2007-07-12 2013-04-23 Tibotec Pharmaceuticals Ltd. Crystalline form of 4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile
AP3551A (en) 2010-01-27 2016-01-18 Viiv Healthcare Co Antiviral therapy
BR112013012245B1 (pt) 2010-11-19 2022-09-27 Janssen Sciences Ireland Uc Comprimido compreendendo hcl de rilpivirina e fumarato de tenofovir disoproxila seu uso no tratamento profilático ou terapêutico de uma infecção por hiv
WO2012125993A1 (fr) 2011-03-17 2012-09-20 Teva Pharmaceutical Industries Ltd. Formes à l'état solide de base rilpivirine et sels de rilpivirine
ES2680146T3 (es) * 2011-09-16 2018-09-04 Hetero Research Foundation Hidrocloruro de rilpivirina
WO2013087794A1 (fr) * 2011-12-14 2013-06-20 Sandoz Ag Polymorphe de chlorhydrate de rilpivirine et son utilisation à titre d'antiviral
EP2604593A1 (fr) * 2011-12-14 2013-06-19 Sandoz AG Polymorphe du chlorhydrate de rilpivirine et son utilisation comme antiviral
EP3528791B1 (fr) 2016-10-24 2023-12-06 Janssen Sciences Ireland Unlimited Company Compositions dispersibles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
MY169670A (en) * 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
CN100554245C (zh) * 2002-08-09 2009-10-28 詹森药业有限公司 制备4-[[4-[[4-(2-氰基乙烯基)-2,6-二甲基苯基]氨基]-2-嘧啶基]氨基]苄腈的方法

Also Published As

Publication number Publication date
CA2577288A1 (fr) 2006-03-09
KR20070074555A (ko) 2007-07-12
AU2005279158B2 (en) 2010-06-17
PL1632232T6 (pl) 2022-06-27
AU2005279158A1 (en) 2006-03-09
WO2006024668A1 (fr) 2006-03-09
AU2005279158C1 (en) 2010-12-16
KR101284361B1 (ko) 2013-07-15
PL1632232T3 (pl) 2011-10-31

Similar Documents

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EP1632232B1 (fr) Sel de 4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]amino]-2-Pyrimidinyl]amino]benzonitrile
CA2577288C (fr) Chlorhydrate de 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile
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US20220008333A1 (en) Dispersible compositions
US20180116964A1 (en) Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
CA2577273C (fr) Fumarate de 4- ( (4- ( (4- (2-cyanoethenyl) -2, 6-dimethylphenyl) amino) -2-pyrimidinyl) amino) benzonitrile
NZ553323A (en) Hydrochloride of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, also named TMC278
NZ553322A (en) Furamate of 4-( (4-( (4- (2-cyanoethenyl) -2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile, also named TMC278

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