CA2575777C - Compositions and methods for treatment of colitis using methimazole and/or cyclic thione derivatives - Google Patents

Compositions and methods for treatment of colitis using methimazole and/or cyclic thione derivatives Download PDF

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Publication number
CA2575777C
CA2575777C CA2575777A CA2575777A CA2575777C CA 2575777 C CA2575777 C CA 2575777C CA 2575777 A CA2575777 A CA 2575777A CA 2575777 A CA2575777 A CA 2575777A CA 2575777 C CA2575777 C CA 2575777C
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group
disease
colitis
tautomeric
derivatives
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Expired - Fee Related
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CA2575777A
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English (en)
French (fr)
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CA2575777A1 (en
Inventor
Leonard D. Kohn
Douglas J. Goetz
Uruguaysito Benavides-Peralta
Marianna Gonzalez-Murguiondo
Norikazu Harii
Christopher J. Lewis
Giorgio Napolitano
Nilesh D. Dagia
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Ohio University
Interthyr Corp
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
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CA2575777A 2004-08-06 2005-07-14 Compositions and methods for treatment of colitis using methimazole and/or cyclic thione derivatives Expired - Fee Related CA2575777C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/912,948 US7928132B2 (en) 2004-08-06 2004-08-06 Methods for the amelioration of episodes of acute or chronic ulcerative colitis
US10/912,948 2004-08-06
PCT/US2005/025067 WO2006019962A1 (en) 2004-08-06 2005-07-14 Compositions and methods for treatment of colitis

Publications (2)

Publication Number Publication Date
CA2575777A1 CA2575777A1 (en) 2006-02-23
CA2575777C true CA2575777C (en) 2011-01-11

Family

ID=35355847

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Application Number Title Priority Date Filing Date
CA2575777A Expired - Fee Related CA2575777C (en) 2004-08-06 2005-07-14 Compositions and methods for treatment of colitis using methimazole and/or cyclic thione derivatives

Country Status (6)

Country Link
US (1) US7928132B2 (https=)
EP (1) EP1773329A1 (https=)
JP (1) JP5039550B2 (https=)
AU (1) AU2005275023B2 (https=)
CA (1) CA2575777C (https=)
WO (1) WO2006019962A1 (https=)

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US20060211752A1 (en) * 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US7943328B1 (en) 2006-03-03 2011-05-17 Prometheus Laboratories Inc. Method and system for assisting in diagnosing irritable bowel syndrome
US20080085524A1 (en) * 2006-08-15 2008-04-10 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome
FR2917087B1 (fr) 2007-06-05 2012-09-21 Galderma Res & Dev Nouveaux 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique.
US20090215908A1 (en) * 2007-09-24 2009-08-27 Reliance Life Sciences Pvt. Ltd. Toll like receptor (tlr) signaling antagonist
BRPI0911195A2 (pt) 2008-04-09 2017-06-20 The Univ Of North Caroline At Chapel Hill métodos de regulação de arranjo de citoesqueleto de actina e formação de gap intracelular
BRPI1010516A2 (pt) * 2009-04-09 2015-08-25 Univ North Carolina Métodos de tratamento de edema relacionados à isquemia-reperfusão
US8367316B2 (en) 2009-05-01 2013-02-05 Alfagene Bioscience, Inc. Human gastrointestinal stem cell-derived primary intestinal epithelial cell system and methods of use thereof
WO2012040636A2 (en) * 2010-09-24 2012-03-29 The Broad Institute, Inc. Compounds and methods for treating diseases mediated by protease activated receptors
US10668092B2 (en) 2010-09-24 2020-06-02 The John Hopkins University Compositions and methods for treatment of inflammatory disorders
KR101213070B1 (ko) 2010-11-09 2012-12-18 부산대학교 산학협력단 포스포리파아제 ｄ１억제제를 유효성분으로 포함하는 류마티스 관절염 예방 또는 치료용 조성물
ES2664237T3 (es) 2012-03-13 2018-04-18 James Cook University Ac-TMP-2 para su uso en el tratamiento de la inflamación
US8865723B2 (en) 2012-10-25 2014-10-21 Tetra Discovery Partners Llc Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury
US20140271666A1 (en) * 2013-03-14 2014-09-18 Immune Pharmaceuticals Ltd. Use of anti-eotaxin antibodies for treating inflammatory bowel disease
SI3043785T1 (sl) 2013-09-13 2022-02-28 National University Corporation Chiba University Uporaba R-ketamina in njegove soli kot farmacevtska sredstva
WO2015039189A1 (en) 2013-09-18 2015-03-26 James Cook University Modified anti-inflammatory proteins and method of use
US9750723B2 (en) 2013-10-31 2017-09-05 Ohio University Prevention and treatment of non-alcoholic fatty liver disease
WO2016010609A1 (en) * 2014-07-18 2016-01-21 Ohio University Prevention and treatment of non-alcoholic fatty liver disease
CN105486869A (zh) * 2014-10-08 2016-04-13 江苏维赛科技生物发展有限公司 一种检测动物源食品中甲巯咪唑残留的酶联免疫试剂盒及其应用
KR101647918B1 (ko) * 2015-03-09 2016-08-11 성균관대학교산학협력단 포스포리파제 d2 억제제를 유효성분으로 포함하는 박테리아 감염 질환 예방 또는 치료용 조성물
JP7548669B2 (ja) * 2018-02-15 2024-09-10 国立大学法人千葉大学 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物
EP4081201A4 (en) * 2019-12-24 2024-01-10 Aardvark Therapeutics Inc. Pharmaceutical composition for treatment or prevention of multiple inflammatory disorders
CN113730444A (zh) * 2021-07-27 2021-12-03 自然资源部第一海洋研究所 一种海带中可溶性膳食纤维在制备用于改善溃疡性结肠炎的药物和功能性食品中的应用
CN114288388B (zh) * 2022-01-25 2023-11-03 华中科技大学同济医学院附属协和医院 网膜素在制备炎症性肠病治疗药物中的应用
CN114903883A (zh) * 2022-05-19 2022-08-16 南华大学附属第一医院 甜菜碱在制备治疗溃疡性结肠炎的药物中的用途
CN116473966B (zh) * 2023-03-29 2025-06-13 广州医科大学 Sb-222200在抑制nlrp3炎症小体活化中的应用
CN119174731B (zh) * 2024-11-15 2025-03-14 温州医科大学附属口腔医院 一种pmc纳米酶及其制备方法
CN120899702A (zh) * 2025-08-06 2025-11-07 大连医科大学附属第一医院 黄素单加氧酶3抑制剂在制备预防和/或治疗急性胰腺炎药物中的应用
CN121489961A (zh) * 2026-01-14 2026-02-10 浙江工商大学 维生素D3在制备缓解MXene致慢性肠炎和/或肠-肝轴损伤的产品中的应用

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WO2005094819A1 (en) * 2004-03-16 2005-10-13 Interthyr Corporation Methimazole derivatives and tautomeric cyclic thiones to inhibit cell adhesion

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Publication number Publication date
WO2006019962B1 (en) 2006-04-20
JP5039550B2 (ja) 2012-10-03
WO2006019962A1 (en) 2006-02-23
JP2008509137A (ja) 2008-03-27
US7928132B2 (en) 2011-04-19
AU2005275023B2 (en) 2012-03-01
AU2005275023A1 (en) 2006-02-23
US20060058365A1 (en) 2006-03-16
EP1773329A1 (en) 2007-04-18
CA2575777A1 (en) 2006-02-23

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