CA2574103A1 - Nouveaux inducteurs puissants de la differenciation terminale et leurs procedes d'utilisation - Google Patents
Nouveaux inducteurs puissants de la differenciation terminale et leurs procedes d'utilisation Download PDFInfo
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- CA2574103A1 CA2574103A1 CA002574103A CA2574103A CA2574103A1 CA 2574103 A1 CA2574103 A1 CA 2574103A1 CA 002574103 A CA002574103 A CA 002574103A CA 2574103 A CA2574103 A CA 2574103A CA 2574103 A1 CA2574103 A1 CA 2574103A1
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- 238000000034 method Methods 0.000 title abstract description 24
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- -1 pyridineamino Chemical group 0.000 claims abstract description 93
- 125000003118 aryl group Chemical group 0.000 claims abstract description 60
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 50
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 47
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract description 33
- 125000004663 dialkyl amino group Chemical group 0.000 claims abstract description 32
- 125000001769 aryl amino group Chemical group 0.000 claims abstract description 31
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 29
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 20
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 17
- 125000004104 aryloxy group Chemical group 0.000 claims abstract description 16
- 125000004947 alkyl aryl amino group Chemical group 0.000 claims description 26
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 17
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- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 8
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- 238000006243 chemical reaction Methods 0.000 description 8
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- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 7
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 7
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- 238000004440 column chromatography Methods 0.000 description 6
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 description 5
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- 238000013268 sustained release Methods 0.000 description 4
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/246,363 US5700811A (en) | 1991-10-04 | 1994-05-19 | Potent inducers of terminal differentiation and method of use thereof |
| US08/246,363 | 1994-05-19 | ||
| CA002190765A CA2190765C (fr) | 1994-05-19 | 1995-05-19 | Nouveaux inducteurs puissants de la differenciation terminale et leurs procedes d'utilisation |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002190765A Division CA2190765C (fr) | 1994-05-19 | 1995-05-19 | Nouveaux inducteurs puissants de la differenciation terminale et leurs procedes d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2574103A1 true CA2574103A1 (fr) | 1995-11-30 |
Family
ID=37912376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002574103A Abandoned CA2574103A1 (fr) | 1994-05-19 | 1995-05-19 | Nouveaux inducteurs puissants de la differenciation terminale et leurs procedes d'utilisation |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2574103A1 (fr) |
-
1995
- 1995-05-19 CA CA002574103A patent/CA2574103A1/fr not_active Abandoned
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |