CA2569095A1 - Structure cristalline de dipeptidyl peptidase iv (dpp-iv) et ses utilisations - Google Patents

Structure cristalline de dipeptidyl peptidase iv (dpp-iv) et ses utilisations Download PDF

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Publication number
CA2569095A1
CA2569095A1 CA002569095A CA2569095A CA2569095A1 CA 2569095 A1 CA2569095 A1 CA 2569095A1 CA 002569095 A CA002569095 A CA 002569095A CA 2569095 A CA2569095 A CA 2569095A CA 2569095 A1 CA2569095 A1 CA 2569095A1
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CA
Canada
Prior art keywords
dpp
computer
amino acid
coordinates
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002569095A
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English (en)
Inventor
Xiayang Qiu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2569095A1 publication Critical patent/CA2569095A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Selon l'invention, une structure cristalline de dipeptidyl peptidase IV (DPP-IV) et les trois coordonnées atomiques tridimensionnelles du domaine extracellulaire de DPP-IV, telles que décrites et utilisées pour l'identification de ligands, dont les inhibiteurs de DPP-IV, sont utilisées pour traiter des maladies associées à des protéines soumises à un traitement par DPP-IV.
CA002569095A 2004-06-03 2005-05-26 Structure cristalline de dipeptidyl peptidase iv (dpp-iv) et ses utilisations Abandoned CA2569095A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57687704P 2004-06-03 2004-06-03
US60/576,877 2004-06-03
PCT/IB2005/001630 WO2005119526A1 (fr) 2004-06-03 2005-05-26 Structure cristalline de dipeptidyl peptidase iv (dpp-iv) et ses utilisations

Publications (1)

Publication Number Publication Date
CA2569095A1 true CA2569095A1 (fr) 2005-12-15

Family

ID=34969993

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002569095A Abandoned CA2569095A1 (fr) 2004-06-03 2005-05-26 Structure cristalline de dipeptidyl peptidase iv (dpp-iv) et ses utilisations

Country Status (4)

Country Link
EP (1) EP1756740A1 (fr)
CA (1) CA2569095A1 (fr)
MX (1) MXPA06014083A (fr)
WO (1) WO2005119526A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
NZ573360A (en) 2006-05-04 2012-08-31 Boehringer Ingelheim Int Polymorphic forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
CA2753884A1 (fr) 2009-02-27 2010-09-02 Trustees Of Tufts College Inhibiteurs de protease assouplissants et formes pro-assouplissantes de ceux-ci
WO2011037793A1 (fr) * 2009-09-25 2011-03-31 Merck Sharp & Dohme Corp. Aminopipéridines substituées utilisées en tant qu'inhibiteurs de la dipeptidyl peptidase-iv dans le cadre du traitement du diabète
EP2366394A1 (fr) * 2010-03-17 2011-09-21 IMTM GmbH Caractérisation et validation d'inhibiteurs et de ligands de la dipeptidyl-aminopeptidase de type IV (DP IV)
EP2571876B1 (fr) * 2010-05-21 2016-09-07 Merck Sharp & Dohme Corp. Composés hétérocycliques substitués à sept chaînons en tant qu'inhibiteurs de la dipeptidyl-peptidase iv pour le traitement du diabète
WO2012017391A2 (fr) * 2010-08-03 2012-02-09 Cadila Pharmaceuticals Limited Nouveaux composés en tant qu'inhibiteurs de la dpp-iv et procédé de préparation associé
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
WO2012170702A1 (fr) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulateurs du récepteur gpr119 et traitement de troubles associés à celui-ci

Also Published As

Publication number Publication date
MXPA06014083A (es) 2007-02-15
WO2005119526A1 (fr) 2005-12-15
EP1756740A1 (fr) 2007-02-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20090526