CA2566313A1 - Medicament housing apparatus having outer and inner containers - Google Patents
Medicament housing apparatus having outer and inner containers Download PDFInfo
- Publication number
- CA2566313A1 CA2566313A1 CA002566313A CA2566313A CA2566313A1 CA 2566313 A1 CA2566313 A1 CA 2566313A1 CA 002566313 A CA002566313 A CA 002566313A CA 2566313 A CA2566313 A CA 2566313A CA 2566313 A1 CA2566313 A1 CA 2566313A1
- Authority
- CA
- Canada
- Prior art keywords
- container
- packaging system
- outer container
- inner container
- medicaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003814 drug Substances 0.000 title claims description 42
- 238000004806 packaging method and process Methods 0.000 claims abstract description 50
- 239000011800 void material Substances 0.000 claims abstract description 10
- -1 polypropylene Polymers 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims description 3
- 239000003242 anti bacterial agent Substances 0.000 claims description 3
- 230000001093 anti-cancer Effects 0.000 claims description 3
- 229940088710 antibiotic agent Drugs 0.000 claims description 3
- 239000003443 antiviral agent Substances 0.000 claims description 3
- 229940121357 antivirals Drugs 0.000 claims description 3
- 210000003169 central nervous system Anatomy 0.000 claims description 3
- 229940111134 coxibs Drugs 0.000 claims description 3
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims description 3
- 230000002526 effect on cardiovascular system Effects 0.000 claims description 3
- 229940077716 histamine h2 receptor antagonists for peptic ulcer and gord Drugs 0.000 claims description 3
- 230000002503 metabolic effect Effects 0.000 claims description 3
- 230000000926 neurological effect Effects 0.000 claims description 3
- 229920002493 poly(chlorotrifluoroethylene) Polymers 0.000 claims description 3
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 3
- 239000004800 polyvinyl chloride Substances 0.000 claims description 3
- 239000005033 polyvinylidene chloride Substances 0.000 claims description 3
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims description 3
- 239000000556 agonist Substances 0.000 claims description 2
- 208000005176 Hepatitis C Diseases 0.000 claims 2
- 208000002672 hepatitis B Diseases 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 239000003521 serotonin 5-HT1 receptor agonist Substances 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000008203 oral pharmaceutical composition Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D23/00—Details of bottles or jars not otherwise provided for
- B65D23/12—Means for the attachment of smaller articles
- B65D23/14—Means for the attachment of smaller articles of tags, labels, cards, coupons, decorations or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
- B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
- B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D11/00—Containers having bodies formed by interconnecting or uniting two or more rigid, or substantially rigid, components made wholly or mainly of plastics material
- B65D11/16—Containers having bodies formed by interconnecting or uniting two or more rigid, or substantially rigid, components made wholly or mainly of plastics material with double walls
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2203/00—Decoration means, markings, information elements, contents indicators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2203/00—Decoration means, markings, information elements, contents indicators
- B65D2203/10—Transponders
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Ceramic Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Details Of Rigid Or Semi-Rigid Containers (AREA)
Abstract
The present invention relates to a packaging system (10) including an outer container (20) and an inner container (70) present within the outer container.
A void space (60) is present between the outer container (20) and the inner container (70) for receiving an outsert (65).
A void space (60) is present between the outer container (20) and the inner container (70) for receiving an outsert (65).
Description
MEDICAMENT HOUSING APPARATUS HAVING OUTER AND INNER
CONTAINERS
Field and Background of the Invention The invention generally relates to packaging for housing medicament.
Numerous examples of packaging pharmaceutical medicament present in oral dosage form are disclosed. Specific examples include those intended to accommodate packaging a variety of predetermined volumes of medicament. To illustrate further, U.S. Patent Nos. 5,315,811; 5,197,602; and io 6,243,936 disclose packaging systems for containing materials therein, and methods for assembling packaging systems for containing materials.
Notwithstanding any potential advantages offered by the above-proposed packaging systems, such systems may be potentially complicated from an assembling perspective in that an individual packaging system is made up of multiple components. It would be desirable to obtain a packaging system that is simpler in structure, thus having the potential to reduce multiple steps in assembling a conventional packaging system.
Summary of the Invention In view of the above, and in one aspect, the present invention provides a packaging system. The packaging system includes a plurality of substantially uniformly shaped containers comprising an outer container and an inner container present within the outer container. The outer container includes a flange and a container wall attached thereto and extending downwardly from the flange. The inner container includes a container wall and a bottom portion attached to the container wall which closes the inner container. Both the outer container and the inner container each have respective cross-sections. The outer container has a bottom portion that is not enclosed, and a void space is present between the outer container and the inner container.
The inner container further includes a neck having a base portion and wherein the flange of said outer container is attached to the base portion. As a result, and advantageously, the outer container and the inner container are a unitary structure.
Brief Description of the Drawings FIGS. 1 a and 1 b respectively are side and bottom cross-sectional views of an embodiment of the packaging system.
FIG. 2 is a perspective view of an embodiment of the packaging system.
FIGS. 3a and 3b respectively are side and bottom cross-sectional io views of an embodiment of the packaging system.
FIG. 4 is a perspective view of an embodiment of the packaging system.
FIG. 5 is a perspective view of an embodiment of an array of packaging systems.
Detailed Description of the Embodiments The present invention will now be described in reference to the embodiments set forth herein, including, without limitation, those described in the drawings. It should be appreciated that these embodiments are for illustrative purposes only, and are not intended to limit the scope of the invention as defined by the claims.
All publications, patents, and patent applications cited herein, whether supra or infra, are hereby incorporated herein by reference in their entirety to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.
It must be noted that, as used in the specification and appended claims, the singular forms "a", "an", "the", and "one" may include plural referents unless the content clearly dictates otherwise.
A number of materials may be employed in forming the outer and inner containers of the invention. For example, these may be formed from a polymer, preferably one or more thermoplastic polymers. Exemplary polymers include at least one material such as, without limitation, polyvinyl chloride, polyvinylidene chloride, polypropylene, polyethylene, polychlorotrifluoroethylene, and combinations thereof. The packaging system of the present invention may be fabricated by employed accepted techniques such as, without limitation, injection molding.
At least one medicament may be housed in the packaging system of the present invention. For the purposes of the invention, the term "medicament", as used herein, is meant to mean and include any substance (i.e., compound or composition of matter) which, when administered to an organism (human or animal) induces a desired pharmacologic and/or io physiologic effect by local and/or systemic action. The term therefore encompasses substances traditionally regarded as actives, drugs and bioactive agents, as well as biopharmaceuticals (e.g., peptides, hormones, nucleic acids, gene constructs, etc.) typically employed to treat a number of conditions which is defined broadly to encompass diseases, disorders, infections, and the like. Exemplary medicaments include, without limitation, antibiotics, antivirals, H2-receptor antagonists, 5HT, agonists, 5HT3 antagonists, COX2-inhibitors, medicaments used in treating psychiatric conditions such as depression, anxiety, bipolar condition, tranquilizers , medicaments used in treating metabolic conditions, anticancer medicaments, medicaments used in treating neurological conditions such as epilepsy and Parkinsons Disease, medicaments used in treating cardiovascular conditions, non-steroidal anti-inflammatory medicaments, medicaments used in treating Central Nervous System conditions, and medicaments employed in treating hepatitis.
The term medicament also encompasses pharmaceutically acceptable salts, esters, solvates, and/or hydrates of the pharmaceutically active substances referred to hereinabove. Various combinations of any of the above medicaments may also be employed.
In accordance with the present invention, the medicament is typically 3o employed in an oral pharmaceutical formulation. An oral pharmaceutical formulation typically refers to the combination of at least one medicament and one or more added components or elements, such as an "excipient" or "carrier." As will be appreciated by one having ordinary skill in the art, the terms "excipient" and "carrier" generally refer to substantially inert materials that are nontoxic and do not interact with other components of the composition in a deleterious manner. Examples of normally employed "excipients," include pharmaceutical grades of carbohydrates, including monosaccharides, disaccharides, cyclodextrins and polysaccharides (e.g., dextrose, sucrose, lactose, raffinose, mannitol, sorbitol, inositol, dextrins and maltodextrins); starch; cellulose; salts (e.g., sodium or calcium phosphates, calcium sulfate, magnesium sulfate); citric acid; tartaric acid; glycine;
leucine;
to high molecular weight polyethylene glyols (PEG); pluronics; surfactants;
lubricants; stearates and their salts or esters (e.g., magnesium stearate);
amino acids; fatty acids; and combinations thereof.
The oral pharmaceutical formulation may be utilized in a variety of unit dosage forms including, without limitation, a tablet, a pill, a capsule, a is lozenge, and combinations thereof. The unit dosage forms may encompass hospital unit dosage forms, as well as others.
The invention will now be described with respect to the drawings. It should be appreciated that the drawings are merely set forth to illustrate the invention and do not serve to limit the scope of the invention as defined by the 20 claims.
FIGS. 1a and 1b depict an embodiment of a packaging system 10 according to the present invention. As shown, the system 10 is present as a unitary structure and includes an outer container 20. In this embodiment, outer container 20 has a cross-sectional area 30 that is circular shaped. The 25 outer container 20 includes a flange 40 and a container wall 50 extending downwardly from flange 40 and throughout the periphery of the flange 40.
The bottom of the container wall 50 is left unclosed such that it is open to the external environment, accordingly, a void space 60 is formed within the container wall 50.
30 Within the void space 60, and as shown in FIG. 1a, an inner container 70 is present. The diameter of the inner container (d) may be selected from various sizes. For example, in one embodiment, the diameter may range from about 1 cm to about 10 cm. A first portion 80 of the inner container 70 extends below flange 40 and into the void space 60 and a second portion 90 .extending above the flange 40. A package outsert (depicted as 65) may be present in the void space 60 formed between the inner container 70 and the outer container 20. The inner container 70 includes a neck 100 having a base portion 110. As depicted in FIG. 1, the flange 40 is attached to inner container 70 at base portion 110 such that the outer container 20 and the inner container 70 are joined and thus present as a unitary structure.
Optionally, and as shown in FIG. 1, the neck 100 of the inner container 70 io may be configured to accommodate a cap. In this embodiment, threads 115 present such that a corresponding cap (not shown) can fit thereon. It should also be appreciated that other configurations may be used in place of, or in combination with threads such as, without limitation, helical locks, lug locks, and the like.
FIG. 2 represents a perspective view of the packaging system 10 illustrated in cross-section in FIG. 1. As shown, in this particular embodiment, a bottle label 120 may be present on outer surface 130 of outer container 20.
Also, in place of, or in addition to label 120, a microelectronic chip having an antenna associated therewith (shown in FIG. 5 as 140) can be attached to outer surface 130. Chip 140 is advantageous in that it allows for the electronic storage and retrieval of information relevant to the product housed within packaging system 10.
FIGS. 1 a, 1 b, and 2 depict the cross-section of outer container 20 being circular shaped. It should be appreciated that, for the purposes of the invention, outer container may have other cross-sectional configurations including, without limitation, circular, triangular, heptagonal, hexagonal, octahedral, etc. As an example, FIGS. 3a, 3b and 4 depict the cross-section of outer container 20 being rectangular (e.g., square) shaped.
FIG. 5 illustrates an array 10' of packaging systems 10 having square cross-sectional areas. As shown, caps 150 are present on the packaging systems 10. Such an embodiment is believed to be advantageous in that it allows for multiple packaging systems to be stored and/or transported in configuration with minimal wasted space between packaging systems, and minimal movement of the packaging systems.
The present invention has been described with respect to the embodiments set forth herein. Nonetheless, it should be noted that such embodiments are merely set forth to illustrate the invention, and do not limit its scope as defined by the claims set forth herein.
CONTAINERS
Field and Background of the Invention The invention generally relates to packaging for housing medicament.
Numerous examples of packaging pharmaceutical medicament present in oral dosage form are disclosed. Specific examples include those intended to accommodate packaging a variety of predetermined volumes of medicament. To illustrate further, U.S. Patent Nos. 5,315,811; 5,197,602; and io 6,243,936 disclose packaging systems for containing materials therein, and methods for assembling packaging systems for containing materials.
Notwithstanding any potential advantages offered by the above-proposed packaging systems, such systems may be potentially complicated from an assembling perspective in that an individual packaging system is made up of multiple components. It would be desirable to obtain a packaging system that is simpler in structure, thus having the potential to reduce multiple steps in assembling a conventional packaging system.
Summary of the Invention In view of the above, and in one aspect, the present invention provides a packaging system. The packaging system includes a plurality of substantially uniformly shaped containers comprising an outer container and an inner container present within the outer container. The outer container includes a flange and a container wall attached thereto and extending downwardly from the flange. The inner container includes a container wall and a bottom portion attached to the container wall which closes the inner container. Both the outer container and the inner container each have respective cross-sections. The outer container has a bottom portion that is not enclosed, and a void space is present between the outer container and the inner container.
The inner container further includes a neck having a base portion and wherein the flange of said outer container is attached to the base portion. As a result, and advantageously, the outer container and the inner container are a unitary structure.
Brief Description of the Drawings FIGS. 1 a and 1 b respectively are side and bottom cross-sectional views of an embodiment of the packaging system.
FIG. 2 is a perspective view of an embodiment of the packaging system.
FIGS. 3a and 3b respectively are side and bottom cross-sectional io views of an embodiment of the packaging system.
FIG. 4 is a perspective view of an embodiment of the packaging system.
FIG. 5 is a perspective view of an embodiment of an array of packaging systems.
Detailed Description of the Embodiments The present invention will now be described in reference to the embodiments set forth herein, including, without limitation, those described in the drawings. It should be appreciated that these embodiments are for illustrative purposes only, and are not intended to limit the scope of the invention as defined by the claims.
All publications, patents, and patent applications cited herein, whether supra or infra, are hereby incorporated herein by reference in their entirety to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.
It must be noted that, as used in the specification and appended claims, the singular forms "a", "an", "the", and "one" may include plural referents unless the content clearly dictates otherwise.
A number of materials may be employed in forming the outer and inner containers of the invention. For example, these may be formed from a polymer, preferably one or more thermoplastic polymers. Exemplary polymers include at least one material such as, without limitation, polyvinyl chloride, polyvinylidene chloride, polypropylene, polyethylene, polychlorotrifluoroethylene, and combinations thereof. The packaging system of the present invention may be fabricated by employed accepted techniques such as, without limitation, injection molding.
At least one medicament may be housed in the packaging system of the present invention. For the purposes of the invention, the term "medicament", as used herein, is meant to mean and include any substance (i.e., compound or composition of matter) which, when administered to an organism (human or animal) induces a desired pharmacologic and/or io physiologic effect by local and/or systemic action. The term therefore encompasses substances traditionally regarded as actives, drugs and bioactive agents, as well as biopharmaceuticals (e.g., peptides, hormones, nucleic acids, gene constructs, etc.) typically employed to treat a number of conditions which is defined broadly to encompass diseases, disorders, infections, and the like. Exemplary medicaments include, without limitation, antibiotics, antivirals, H2-receptor antagonists, 5HT, agonists, 5HT3 antagonists, COX2-inhibitors, medicaments used in treating psychiatric conditions such as depression, anxiety, bipolar condition, tranquilizers , medicaments used in treating metabolic conditions, anticancer medicaments, medicaments used in treating neurological conditions such as epilepsy and Parkinsons Disease, medicaments used in treating cardiovascular conditions, non-steroidal anti-inflammatory medicaments, medicaments used in treating Central Nervous System conditions, and medicaments employed in treating hepatitis.
The term medicament also encompasses pharmaceutically acceptable salts, esters, solvates, and/or hydrates of the pharmaceutically active substances referred to hereinabove. Various combinations of any of the above medicaments may also be employed.
In accordance with the present invention, the medicament is typically 3o employed in an oral pharmaceutical formulation. An oral pharmaceutical formulation typically refers to the combination of at least one medicament and one or more added components or elements, such as an "excipient" or "carrier." As will be appreciated by one having ordinary skill in the art, the terms "excipient" and "carrier" generally refer to substantially inert materials that are nontoxic and do not interact with other components of the composition in a deleterious manner. Examples of normally employed "excipients," include pharmaceutical grades of carbohydrates, including monosaccharides, disaccharides, cyclodextrins and polysaccharides (e.g., dextrose, sucrose, lactose, raffinose, mannitol, sorbitol, inositol, dextrins and maltodextrins); starch; cellulose; salts (e.g., sodium or calcium phosphates, calcium sulfate, magnesium sulfate); citric acid; tartaric acid; glycine;
leucine;
to high molecular weight polyethylene glyols (PEG); pluronics; surfactants;
lubricants; stearates and their salts or esters (e.g., magnesium stearate);
amino acids; fatty acids; and combinations thereof.
The oral pharmaceutical formulation may be utilized in a variety of unit dosage forms including, without limitation, a tablet, a pill, a capsule, a is lozenge, and combinations thereof. The unit dosage forms may encompass hospital unit dosage forms, as well as others.
The invention will now be described with respect to the drawings. It should be appreciated that the drawings are merely set forth to illustrate the invention and do not serve to limit the scope of the invention as defined by the 20 claims.
FIGS. 1a and 1b depict an embodiment of a packaging system 10 according to the present invention. As shown, the system 10 is present as a unitary structure and includes an outer container 20. In this embodiment, outer container 20 has a cross-sectional area 30 that is circular shaped. The 25 outer container 20 includes a flange 40 and a container wall 50 extending downwardly from flange 40 and throughout the periphery of the flange 40.
The bottom of the container wall 50 is left unclosed such that it is open to the external environment, accordingly, a void space 60 is formed within the container wall 50.
30 Within the void space 60, and as shown in FIG. 1a, an inner container 70 is present. The diameter of the inner container (d) may be selected from various sizes. For example, in one embodiment, the diameter may range from about 1 cm to about 10 cm. A first portion 80 of the inner container 70 extends below flange 40 and into the void space 60 and a second portion 90 .extending above the flange 40. A package outsert (depicted as 65) may be present in the void space 60 formed between the inner container 70 and the outer container 20. The inner container 70 includes a neck 100 having a base portion 110. As depicted in FIG. 1, the flange 40 is attached to inner container 70 at base portion 110 such that the outer container 20 and the inner container 70 are joined and thus present as a unitary structure.
Optionally, and as shown in FIG. 1, the neck 100 of the inner container 70 io may be configured to accommodate a cap. In this embodiment, threads 115 present such that a corresponding cap (not shown) can fit thereon. It should also be appreciated that other configurations may be used in place of, or in combination with threads such as, without limitation, helical locks, lug locks, and the like.
FIG. 2 represents a perspective view of the packaging system 10 illustrated in cross-section in FIG. 1. As shown, in this particular embodiment, a bottle label 120 may be present on outer surface 130 of outer container 20.
Also, in place of, or in addition to label 120, a microelectronic chip having an antenna associated therewith (shown in FIG. 5 as 140) can be attached to outer surface 130. Chip 140 is advantageous in that it allows for the electronic storage and retrieval of information relevant to the product housed within packaging system 10.
FIGS. 1 a, 1 b, and 2 depict the cross-section of outer container 20 being circular shaped. It should be appreciated that, for the purposes of the invention, outer container may have other cross-sectional configurations including, without limitation, circular, triangular, heptagonal, hexagonal, octahedral, etc. As an example, FIGS. 3a, 3b and 4 depict the cross-section of outer container 20 being rectangular (e.g., square) shaped.
FIG. 5 illustrates an array 10' of packaging systems 10 having square cross-sectional areas. As shown, caps 150 are present on the packaging systems 10. Such an embodiment is believed to be advantageous in that it allows for multiple packaging systems to be stored and/or transported in configuration with minimal wasted space between packaging systems, and minimal movement of the packaging systems.
The present invention has been described with respect to the embodiments set forth herein. Nonetheless, it should be noted that such embodiments are merely set forth to illustrate the invention, and do not limit its scope as defined by the claims set forth herein.
Claims (21)
1. A packaging system comprising:
a plurality of substantially uniformly shaped containers comprising an outer container and an inner container present within said outer container, said outer container including a flange and a container wall attached thereto and extending downwardly from the flange, said inner container including a container wall and a bottom portion attached to the container wall which closes the inner container, said outer container and said inner container each having respective cross-sections;
said outer container having a bottom portion that is not enclosed, wherein a void space is present between the outer container and the inner container; and said inner container further including a neck having a base portion and wherein the flange of said outer container is attached to the base portion such that said outer container and said inner container are a unitary structure.
a plurality of substantially uniformly shaped containers comprising an outer container and an inner container present within said outer container, said outer container including a flange and a container wall attached thereto and extending downwardly from the flange, said inner container including a container wall and a bottom portion attached to the container wall which closes the inner container, said outer container and said inner container each having respective cross-sections;
said outer container having a bottom portion that is not enclosed, wherein a void space is present between the outer container and the inner container; and said inner container further including a neck having a base portion and wherein the flange of said outer container is attached to the base portion such that said outer container and said inner container are a unitary structure.
2. The packaging system according to Claim 1, wherein a package outsert is positioned in the void space between the outer container and the inner container.
3. The packaging system according to Claim 1, wherein the neck of said inner container is configured to accommodate a bottle cap.
4. The packaging system according to Claim 1, wherein said outer container and said inner container are formed from a polymer.
5. The packaging system according to Claim 4, wherein the polymer comprises at least one material selected from the group consisting of polyvinyl chloride, polyvinylidene chloride, polypropylene, polyethylene, polychlorotrifluoroethylene, and combinations thereof.
6. The packaging system according to Claim 1, wherein the inner diameter ranges in size from about 1 cm to about 10 cm.
7. The packaging system according to Claim 1, wherein at least one medicament is housed in said packaging system.
8. The packaging system according to Claim 7, wherein the at least one medicament is selected from the group consisting of antibiotics, antivirals, H2-receptor antagonists, 5HT, agonists, 5HT3 antagonists, COX2-inhibitors, medicaments used in treating psychiatric conditions, medicaments used in treating metabolic conditions, anticancer medicaments, medicaments used in treating neurological conditions, medicaments used in treating cardiovascular conditions, non-steroidal anti-inflammatories medicaments, medicaments used in treating Central Nervous System conditions, and medicaments employed in treating Hepatitis B and C.
9. The packaging system according to Claim 1, wherein the cross--section of the inner container is circular.
10. The packaging system according to Claim 1, wherein the cross--section of the outer container is circular
11. The packaging system according to Claim 1, wherein the cross--section of the outer container is square.
12. A packaging system comprising:
a plurality of substantially uniformly shaped containers of different diameters, said plurality of substantially uniformly shaped containers comprising an outer container having a first diameter and an inner container having a second diameter smaller relative to the first diameter, said inner container being present within said outer container, said outer container including a flange and a container wall attached thereto and extending downwardly from the flange, said inner container including a container wall and a bottom portion attached to the container wall which closes the inner container, wherein said inner container houses at least one medicament therein;
said outer container having a bottom portion that is not enclosed, wherein a void space is present between the outer container and the inner container; and said inner container further including a neck having a base portion and wherein the flange of said outer container is attached to the base portion such that said outer container and said inner container are a unitary structure, and wherein the neck is configured to accommodate a bottle cap.
a plurality of substantially uniformly shaped containers of different diameters, said plurality of substantially uniformly shaped containers comprising an outer container having a first diameter and an inner container having a second diameter smaller relative to the first diameter, said inner container being present within said outer container, said outer container including a flange and a container wall attached thereto and extending downwardly from the flange, said inner container including a container wall and a bottom portion attached to the container wall which closes the inner container, wherein said inner container houses at least one medicament therein;
said outer container having a bottom portion that is not enclosed, wherein a void space is present between the outer container and the inner container; and said inner container further including a neck having a base portion and wherein the flange of said outer container is attached to the base portion such that said outer container and said inner container are a unitary structure, and wherein the neck is configured to accommodate a bottle cap.
13. The packaging system according to Claim 12, wherein a package outsert is positioned in the void space between the outer container and the inner container.
14. The packaging system according to Claim 12, wherein said outer container and said inner container are formed from a polymer.
15. The packaging system according to Claim 14, wherein the polymer comprises at least one material selected from the group consisting of polyvinyl chloride, polyvinylidene chloride, polypropylene, polyethylene, polychlorotrifluoroethylene, and combinations thereof.
16. The packaging system according to Claim 12, wherein the inner diameter ranges in size from about 1 cm to about 10 cm.
17. The packaging system according to Claim 12, wherein the at least one medicament is selected from the group consisting of antibiotics, antivirals, H2-receptor antagonists, 5HT1 agonists, 5HT3 antagonists, COX2-inhibitors, medicaments used in treating psychiatric conditions, medicaments used in treating metabolic conditions, anticancer medicaments, medicaments used in treating neurological conditions, medicaments used in treating cardiovascular conditions, non-steroidal anti-inflammatories medicaments, medicaments used in treating Central Nervous System conditions, and medicaments employed in treating Hepatitis B and C.
18. The packaging system according to Claim 12, wherein the cross-section of the inner container is circular.
19. The packaging system according to Claim 12, wherein the cross-section of the outer container is circular
20. The packaging system according to Claim 12, wherein the cross-section of the outer container is square.
21. An array of packaging systems for housing medicament therein, wherein each of the packaging systems are defined according to Claim 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57345304P | 2004-05-21 | 2004-05-21 | |
| US60/573,453 | 2004-05-21 | ||
| PCT/US2005/017027 WO2005115869A1 (en) | 2004-05-21 | 2005-05-16 | Medicament housing apparatus having outer and inner containers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2566313A1 true CA2566313A1 (en) | 2005-12-08 |
Family
ID=35450766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002566313A Abandoned CA2566313A1 (en) | 2004-05-21 | 2005-05-16 | Medicament housing apparatus having outer and inner containers |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070209331A1 (en) |
| EP (1) | EP1755978A1 (en) |
| JP (1) | JP2008500133A (en) |
| CA (1) | CA2566313A1 (en) |
| IL (1) | IL179034A0 (en) |
| WO (1) | WO2005115869A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0720951A2 (en) * | 2007-01-20 | 2014-03-18 | Merck Patent Gmbh | PACKAGING CONTAINING SOFT CAPSULES. |
| CN111056122A (en) * | 2020-01-16 | 2020-04-24 | 中船第九设计研究院工程有限公司 | Sanitary anti-pollution type packaging container |
| JP2023553284A (en) * | 2020-11-20 | 2023-12-21 | エスアイオーツー・メディカル・プロダクツ・インコーポレイテッド | Polymer vials with standard external dimensions and reduced internal volume |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2000419A (en) * | 1934-01-18 | 1935-05-07 | Emery N Sarber | Advertising condiment shaker |
| US2493922A (en) * | 1945-02-13 | 1950-01-10 | Coeur Company | Container |
| US2945314A (en) * | 1957-10-17 | 1960-07-19 | Brian E Baldwin | Display device |
| US3374911A (en) * | 1967-05-15 | 1968-03-26 | Robert V. White | Plastic cosmetic jar |
| US4871077A (en) * | 1987-04-27 | 1989-10-03 | Doxtech, Inc. | Tamper resistant, tamper evident leak proof container |
| US6243936B1 (en) * | 1991-05-30 | 2001-06-12 | Drug Plastics And Glass Company, Inc. | Method for assembling an outer container having a container insert therein for holding a predetermined volume of material |
| US5315811A (en) * | 1991-05-30 | 1994-05-31 | Drug Plastics & Glass Company, Inc. | Method of packaging with an outer container having a container insert for holding a predetermined volume of material |
| US5197602A (en) * | 1991-05-30 | 1993-03-30 | Drug Plastics & Glass Company, Inc. | Packing system comprising a plurality of outer containers having container inserts therein for holding a predetermined volume of material |
| US5318183A (en) * | 1991-09-19 | 1994-06-07 | Glaxo, Inc. | Bottle with insert to reduce effective volume |
| GB9519196D0 (en) * | 1995-09-20 | 1995-11-22 | Jaycare Ltd | Improvements relating to packaging containers |
| US6076697A (en) * | 1997-06-09 | 2000-06-20 | Allabaugh, Jr.; Robert Carleton | Crate for cartons |
| JP4462689B2 (en) * | 2000-01-18 | 2010-05-12 | 株式会社トーショー | Chemical storage device |
| US6360462B1 (en) * | 2000-04-10 | 2002-03-26 | Mcneil-Ppc, Inc. | Container with label |
| US6301812B1 (en) * | 2000-09-19 | 2001-10-16 | Richard Klunk | Gift container and associated methods |
| US20030071040A1 (en) * | 2001-10-17 | 2003-04-17 | Olcott Plastics | Jar container and method of making same |
| US20040045863A1 (en) * | 2002-09-06 | 2004-03-11 | Rhoades Dean L. | Container with extractable and retractable instructions |
-
2005
- 2005-05-16 EP EP05749362A patent/EP1755978A1/en not_active Withdrawn
- 2005-05-16 CA CA002566313A patent/CA2566313A1/en not_active Abandoned
- 2005-05-16 JP JP2007527335A patent/JP2008500133A/en active Pending
- 2005-05-16 WO PCT/US2005/017027 patent/WO2005115869A1/en not_active Application Discontinuation
- 2005-05-16 US US11/568,992 patent/US20070209331A1/en not_active Abandoned
-
2006
- 2006-11-02 IL IL179034A patent/IL179034A0/en unknown
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| Publication number | Publication date |
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| JP2008500133A (en) | 2008-01-10 |
| US20070209331A1 (en) | 2007-09-13 |
| IL179034A0 (en) | 2007-03-08 |
| EP1755978A1 (en) | 2007-02-28 |
| WO2005115869A1 (en) | 2005-12-08 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued |