CA2558908A1 - Derives de 10-desacetylbaccatine iii et de 10-desacetyl-14.beta.-hydroxybaccatine iii et composes intermediaires pouvant servir a la synthese desdits derives - Google Patents
Derives de 10-desacetylbaccatine iii et de 10-desacetyl-14.beta.-hydroxybaccatine iii et composes intermediaires pouvant servir a la synthese desdits derives Download PDFInfo
- Publication number
- CA2558908A1 CA2558908A1 CA002558908A CA2558908A CA2558908A1 CA 2558908 A1 CA2558908 A1 CA 2558908A1 CA 002558908 A CA002558908 A CA 002558908A CA 2558908 A CA2558908 A CA 2558908A CA 2558908 A1 CA2558908 A1 CA 2558908A1
- Authority
- CA
- Canada
- Prior art keywords
- iii
- deacetyl
- beta
- preparation
- intermediates useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000543 intermediate Substances 0.000 title claims abstract 3
- YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 title abstract 2
- YWLXLRUDGLRYDR-LUPIKGFISA-N 7-epi-10-deacetylbaccatin iii Chemical group O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-LUPIKGFISA-N 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical group NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- 229940123237 Taxane Drugs 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
Landscapes
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI95A000533 | 1995-03-17 | ||
| IT95MI000533A IT1275936B1 (it) | 1995-03-17 | 1995-03-17 | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
| CA002215682A CA2215682C (fr) | 1995-03-17 | 1996-03-04 | Derives de 10-deacetylbaccatine iii et de 10-deacetyl-14.beta.-hydroxybaccatine iii, leur procede de preparation et compositions pharmaceutiques les contenant |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002215682A Division CA2215682C (fr) | 1995-03-17 | 1996-03-04 | Derives de 10-deacetylbaccatine iii et de 10-deacetyl-14.beta.-hydroxybaccatine iii, leur procede de preparation et compositions pharmaceutiques les contenant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2558908A1 true CA2558908A1 (fr) | 1996-09-26 |
| CA2558908C CA2558908C (fr) | 2009-12-22 |
Family
ID=37441499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002558908A Expired - Lifetime CA2558908C (fr) | 1995-03-17 | 1996-03-04 | Derives de 10-desacetylbaccatine iii et de 10-desacetyl-14.beta.-hydroxybaccatine iii et composes intermediaires pouvant servir a la synthese desdits derives |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2558908C (fr) |
-
1996
- 1996-03-04 CA CA002558908A patent/CA2558908C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2558908C (fr) | 2009-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20160304 |