CA2556450C - Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof - Google Patents
Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof Download PDFInfo
- Publication number
- CA2556450C CA2556450C CA2556450A CA2556450A CA2556450C CA 2556450 C CA2556450 C CA 2556450C CA 2556450 A CA2556450 A CA 2556450A CA 2556450 A CA2556450 A CA 2556450A CA 2556450 C CA2556450 C CA 2556450C
- Authority
- CA
- Canada
- Prior art keywords
- zolpidem
- pharmaceutical composition
- buffer
- bicarbonate
- carbonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 268
- 210000002200 mouth mucosa Anatomy 0.000 title claims abstract description 75
- 239000003326 hypnotic agent Substances 0.000 title abstract description 139
- 238000000034 method Methods 0.000 title abstract description 38
- 239000007853 buffer solution Substances 0.000 claims abstract description 159
- 210000003296 saliva Anatomy 0.000 claims abstract description 88
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims abstract description 21
- 206010022437 insomnia Diseases 0.000 claims abstract description 20
- ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 claims description 207
- 229960001475 zolpidem Drugs 0.000 claims description 198
- 239000003826 tablet Substances 0.000 claims description 112
- 239000007937 lozenge Substances 0.000 claims description 90
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 73
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 72
- 239000000872 buffer Substances 0.000 claims description 70
- 239000011230 binding agent Substances 0.000 claims description 61
- 239000008194 pharmaceutical composition Substances 0.000 claims description 58
- 210000000214 mouth Anatomy 0.000 claims description 48
- 150000003839 salts Chemical class 0.000 claims description 45
- 239000007787 solid Substances 0.000 claims description 40
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- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 36
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 36
- 235000017550 sodium carbonate Nutrition 0.000 claims description 36
- 239000003795 chemical substances by application Substances 0.000 claims description 33
- 210000004877 mucosa Anatomy 0.000 claims description 33
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 31
- 230000036470 plasma concentration Effects 0.000 claims description 31
- 210000004379 membrane Anatomy 0.000 claims description 22
- 239000012528 membrane Substances 0.000 claims description 22
- 210000005178 buccal mucosa Anatomy 0.000 claims description 19
- XWSCOGPKWVNQSV-UHFFFAOYSA-N 5-bromo-2,3-dichloropyridine Chemical group ClC1=CC(Br)=CN=C1Cl XWSCOGPKWVNQSV-UHFFFAOYSA-N 0.000 claims description 14
- 229960005111 zolpidem tartrate Drugs 0.000 claims description 14
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 11
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
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- OABYVIYXWMZFFJ-ZUHYDKSRSA-M sodium glycocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 OABYVIYXWMZFFJ-ZUHYDKSRSA-M 0.000 description 1
- VMSNAUAEKXEYGP-YEUHZSMFSA-M sodium glycodeoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 VMSNAUAEKXEYGP-YEUHZSMFSA-M 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- 229940045946 sodium taurodeoxycholate Drugs 0.000 description 1
- YXHRQQJFKOHLAP-FVCKGWAHSA-M sodium;2-[[(4r)-4-[(3r,5r,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 YXHRQQJFKOHLAP-FVCKGWAHSA-M 0.000 description 1
- 210000001584 soft palate Anatomy 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 229940061368 sonata Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229940098466 sublingual tablet Drugs 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000001019 trigonella foenum-graecum Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2816904A CA2816904A1 (en) | 2004-02-17 | 2005-02-16 | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78311804A | 2004-02-17 | 2004-02-17 | |
| US60/608,957 | 2004-02-17 | ||
| US59862904P | 2004-08-03 | 2004-08-03 | |
| US60/598,629 | 2004-08-03 | ||
| PCT/US2005/005021 WO2005079761A1 (en) | 2004-02-17 | 2005-02-16 | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2816904A Division CA2816904A1 (en) | 2004-02-17 | 2005-02-16 | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2556450A1 CA2556450A1 (en) | 2005-09-01 |
| CA2556450C true CA2556450C (en) | 2013-08-06 |
Family
ID=34890604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2556450A Expired - Fee Related CA2556450C (en) | 2004-02-17 | 2005-02-16 | Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof |
Country Status (7)
| Country | Link |
|---|---|
| AU (1) | AU2005215782B2 (pt) |
| BR (1) | BRPI0507733A (pt) |
| CA (1) | CA2556450C (pt) |
| IL (1) | IL177227A (pt) |
| MX (1) | MXPA06009296A (pt) |
| NZ (1) | NZ548856A (pt) |
| WO (1) | WO2005079761A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0423800D0 (en) | 2004-10-27 | 2004-12-01 | Orexo Ab | New pharmaceutical formulations |
| US20070123562A1 (en) * | 2005-05-25 | 2007-05-31 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the-night insomnia |
| EP2142183A2 (en) * | 2007-04-09 | 2010-01-13 | Sepracor Inc. | Methods and compositions comprising desvenlafaxine or duloxetine for treating sleep-related breathing disorders |
| FR2968992B1 (fr) * | 2010-12-16 | 2013-02-08 | Sanofi Aventis | Comprime pharmaceutique orodispersible a base de zolpidem |
| CN103919780B (zh) * | 2012-12-26 | 2016-12-28 | 上海中西制药有限公司 | 镇静安眠制剂、其复方制剂、制备方法及药物组合物 |
| EA202190765A1 (ru) | 2018-10-08 | 2021-07-01 | Троикаа Фармасьютикалз Лимитед | Растворы золпидема или его фармацевтически приемлемых солей для оромукозного введения |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW370529B (en) * | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
| US6005109A (en) * | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
| US6624162B2 (en) * | 2001-10-22 | 2003-09-23 | Pfizer Inc. | Imidazopyridine compounds as 5-HT4 receptor modulators |
-
2005
- 2005-02-16 AU AU2005215782A patent/AU2005215782B2/en not_active Ceased
- 2005-02-16 NZ NZ548856A patent/NZ548856A/en not_active IP Right Cessation
- 2005-02-16 BR BRPI0507733-8A patent/BRPI0507733A/pt not_active Application Discontinuation
- 2005-02-16 MX MXPA06009296A patent/MXPA06009296A/es active IP Right Grant
- 2005-02-16 WO PCT/US2005/005021 patent/WO2005079761A1/en not_active Ceased
- 2005-02-16 CA CA2556450A patent/CA2556450C/en not_active Expired - Fee Related
-
2006
- 2006-08-02 IL IL177227A patent/IL177227A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005215782A1 (en) | 2005-09-01 |
| MXPA06009296A (es) | 2007-01-26 |
| AU2005215782B2 (en) | 2011-04-21 |
| IL177227A (en) | 2013-05-30 |
| WO2005079761A1 (en) | 2005-09-01 |
| CA2556450A1 (en) | 2005-09-01 |
| BRPI0507733A (pt) | 2007-07-10 |
| IL177227A0 (en) | 2006-12-10 |
| NZ548856A (en) | 2009-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180216 |