CA2554559A1 - Multiparticulate o-desmethylvenlafaxine salts and uses thereof - Google Patents
Multiparticulate o-desmethylvenlafaxine salts and uses thereof Download PDFInfo
- Publication number
- CA2554559A1 CA2554559A1 CA002554559A CA2554559A CA2554559A1 CA 2554559 A1 CA2554559 A1 CA 2554559A1 CA 002554559 A CA002554559 A CA 002554559A CA 2554559 A CA2554559 A CA 2554559A CA 2554559 A1 CA2554559 A1 CA 2554559A1
- Authority
- CA
- Canada
- Prior art keywords
- multiparticulate
- odv
- formulation
- formate
- formulation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- KYYIDSXMWOZKMP-UHFFFAOYSA-N O-desmethylvenlafaxine Chemical class C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 KYYIDSXMWOZKMP-UHFFFAOYSA-N 0.000 title claims abstract description 62
- 238000000034 method Methods 0.000 claims abstract description 19
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims abstract description 14
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims abstract description 14
- 230000000694 effects Effects 0.000 claims abstract description 13
- 230000002496 gastric effect Effects 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims description 60
- 238000009472 formulation Methods 0.000 claims description 55
- ORUUBRMVQCKYHB-UHFFFAOYSA-N butanedioic acid;4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol Chemical compound OC(=O)CCC(O)=O.C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 ORUUBRMVQCKYHB-UHFFFAOYSA-N 0.000 claims description 30
- 239000008188 pellet Substances 0.000 claims description 20
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 18
- 239000001856 Ethyl cellulose Substances 0.000 claims description 14
- 229920001249 ethyl cellulose Polymers 0.000 claims description 14
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 14
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims description 14
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 11
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K9/5005—Wall or coating material
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- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54238404P | 2004-02-06 | 2004-02-06 | |
| US60/542,384 | 2004-02-06 | ||
| PCT/US2005/002215 WO2005077340A1 (en) | 2004-02-06 | 2005-01-25 | Multiparticulate o-desmethylvenlafaxine salts and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2554559A1 true CA2554559A1 (en) | 2005-08-25 |
Family
ID=34860300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002554559A Abandoned CA2554559A1 (en) | 2004-02-06 | 2005-01-25 | Multiparticulate o-desmethylvenlafaxine salts and uses thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20050175698A1 (https=) |
| EP (2) | EP2052717A1 (https=) |
| JP (1) | JP2007520553A (https=) |
| KR (1) | KR20060132891A (https=) |
| CN (1) | CN1917860A (https=) |
| AR (1) | AR050230A1 (https=) |
| AU (1) | AU2005212166A1 (https=) |
| BR (1) | BRPI0507372A (https=) |
| CA (1) | CA2554559A1 (https=) |
| CR (1) | CR8535A (https=) |
| EC (1) | ECSP066827A (https=) |
| IL (1) | IL177052A0 (https=) |
| NO (1) | NO20063963L (https=) |
| PA (1) | PA8622601A1 (https=) |
| PE (1) | PE20050771A1 (https=) |
| RU (1) | RU2006127437A (https=) |
| SG (1) | SG149894A1 (https=) |
| SV (1) | SV2005002008A (https=) |
| TW (1) | TW200528092A (https=) |
| WO (1) | WO2005077340A1 (https=) |
| ZA (1) | ZA200606526B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6342533B1 (en) * | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| PL350924A1 (en) * | 1999-04-06 | 2003-02-10 | Sepracor Inc | Derivatives of venlafaxine and methods of preparing and using the same |
| AU2002250058B2 (en) | 2001-02-12 | 2007-08-16 | Wyeth Llc | Novel succinate salt of O-desmethyl-venlafaxine |
| US20080103171A1 (en) * | 2004-12-27 | 2008-05-01 | Astellas Pharma Inc. | Stable Particular Pharmaceutical Composition of Solifenacin or Salt Thereof |
| DE602006010343D1 (de) * | 2005-03-31 | 2009-12-24 | Wyeth Corp | Kombinationsprodukt aus o-desmethylvenlafaxin und bazedoxifen und verwendungen davon |
| WO2007005961A2 (en) * | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| US7595340B2 (en) | 2005-07-15 | 2009-09-29 | Wyeth | Serotonin and norepinephrine reuptake inhibitor and uses thereof |
| US20070014859A1 (en) * | 2005-07-15 | 2007-01-18 | Wyeth | Highly bioavailable oral delayed release dosage forms of O-desmethylvenlafaxine succinate |
| US20070015828A1 (en) * | 2005-07-15 | 2007-01-18 | Wyeth | Highly selective serotonin and norepinephrine dual reuptake inhibitor and use thereof |
| US7687520B2 (en) | 2005-07-15 | 2010-03-30 | Wyeth Llc | Serotonin and norepinephrine reuptake inhibitors and uses thereof |
| TW200806282A (en) * | 2006-05-05 | 2008-02-01 | Wyeth Corp | Solid dosage formulations |
| EP1870395A1 (en) | 2006-06-19 | 2007-12-26 | KRKA, D.D., Novo Mesto | Process for preparation of o-desmethylvenlafaxine and its analogue |
| TR200909798T1 (tr) * | 2007-07-12 | 2010-05-21 | Dr. Reddy's Laboratories Ltd. | O-desmetilvenlafaksin. |
| CA2702664A1 (en) * | 2007-10-16 | 2009-04-23 | Alphapharm Pty Ltd | Controlled-release pharmaceutical formulation |
| US20110046231A1 (en) * | 2007-10-22 | 2011-02-24 | Actavis Group Ptc Ehf | Solid forms of (±)-o-desmethylvenlafaxine salts |
| MX2012010659A (es) | 2010-03-31 | 2013-03-05 | Wockhardt Ltd | Composicion farmaceutica de liberacion modificada que comprende desvenlafaxina o sus sales. |
| KR20140030156A (ko) | 2011-04-12 | 2014-03-11 | 루핀 리미티드 | 방출-조절되는 데스벤라팍신 약학 조성물 |
| WO2013164559A1 (en) * | 2012-05-03 | 2013-11-07 | Cipla Limited | Antiretroviral composition |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3081496A (en) * | 1959-10-15 | 1963-03-19 | John F Moore | Method of forming flexible sheets of cured foamed rubber |
| AT294000B (de) * | 1965-01-11 | 1971-11-10 | Diersch & Schroeder | Verfahren zur Herstellung von Teppichen oder Läufern |
| US3885257A (en) * | 1972-10-30 | 1975-05-27 | Evans Ronald J P | Pressure controlled resilient supporting structure |
| US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
| US4603445A (en) * | 1983-09-09 | 1986-08-05 | Span-America Medical Systems, Inc. | Support pad and method of manufacture |
| US5099627A (en) * | 1990-09-28 | 1992-03-31 | Benjamin Obdyke Incorporated | Ventilated roof construction and method |
| US5203703A (en) * | 1991-08-27 | 1993-04-20 | Schneiderman Marc J | Deglutition training method and apparatus |
| US7048906B2 (en) * | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| US6274171B1 (en) * | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
| US6162309A (en) * | 1998-04-21 | 2000-12-19 | Burlington Industries, Inc. | Reinforced foam backed carpet |
| US6197828B1 (en) * | 1998-12-01 | 2001-03-06 | Sepracor, Inc. | Derivatives of (+)-venlafaxine and methods of preparing and using the same |
| US6342533B1 (en) * | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
| PL350924A1 (en) * | 1999-04-06 | 2003-02-10 | Sepracor Inc | Derivatives of venlafaxine and methods of preparing and using the same |
| WO2000076955A1 (en) * | 1999-06-15 | 2000-12-21 | American Home Products Corporation | Enantiomers of o-desmethyl venlafaxine |
| US6863972B2 (en) * | 2001-01-09 | 2005-03-08 | Crane Plastics Company Llc | Synthetic wood component having a foamed polymer backing |
| AU2002250058B2 (en) * | 2001-02-12 | 2007-08-16 | Wyeth Llc | Novel succinate salt of O-desmethyl-venlafaxine |
| US20030152741A1 (en) * | 2002-02-05 | 2003-08-14 | Robbins Jeffrey L. | Patterned polyurethane foam and a process for the production of tufted goods with patterned foam backing |
| US20030190352A1 (en) * | 2002-03-28 | 2003-10-09 | Synthon Bv | Compositions of venlafaxine base |
| AU2003247515A1 (en) | 2002-06-10 | 2003-12-22 | Wyeth | Novel formate salt of o-desmethyl-venlafaxine |
| JP2004359665A (ja) * | 2003-05-30 | 2004-12-24 | Rohm & Haas Co | 生体利用性増強剤を含有する治療組成物 |
-
2005
- 2005-01-25 AU AU2005212166A patent/AU2005212166A1/en not_active Abandoned
- 2005-01-25 SG SG200900798-0A patent/SG149894A1/en unknown
- 2005-01-25 CA CA002554559A patent/CA2554559A1/en not_active Abandoned
- 2005-01-25 KR KR1020067015668A patent/KR20060132891A/ko not_active Withdrawn
- 2005-01-25 US US11/042,436 patent/US20050175698A1/en not_active Abandoned
- 2005-01-25 BR BRPI0507372-3A patent/BRPI0507372A/pt not_active IP Right Cessation
- 2005-01-25 EP EP09002123A patent/EP2052717A1/en not_active Withdrawn
- 2005-01-25 CN CNA2005800042516A patent/CN1917860A/zh active Pending
- 2005-01-25 WO PCT/US2005/002215 patent/WO2005077340A1/en not_active Ceased
- 2005-01-25 RU RU2006127437/15A patent/RU2006127437A/ru not_active Application Discontinuation
- 2005-01-25 JP JP2006552145A patent/JP2007520553A/ja not_active Withdrawn
- 2005-01-25 AR ARP050100248A patent/AR050230A1/es unknown
- 2005-01-25 EP EP05711931A patent/EP1711167A1/en not_active Withdrawn
- 2005-01-27 TW TW094102533A patent/TW200528092A/zh unknown
- 2005-01-31 PE PE2005000114A patent/PE20050771A1/es not_active Application Discontinuation
- 2005-02-03 PA PA20058622601A patent/PA8622601A1/es unknown
- 2005-02-04 SV SV2005002008A patent/SV2005002008A/es not_active Application Discontinuation
-
2006
- 2006-07-24 IL IL177052A patent/IL177052A0/en unknown
- 2006-07-25 CR CR8535A patent/CR8535A/es not_active Application Discontinuation
- 2006-08-04 ZA ZA200606526A patent/ZA200606526B/xx unknown
- 2006-09-05 NO NO20063963A patent/NO20063963L/no not_active Application Discontinuation
- 2006-09-06 EC EC2006006827A patent/ECSP066827A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SV2005002008A (es) | 2005-11-04 |
| EP2052717A1 (en) | 2009-04-29 |
| JP2007520553A (ja) | 2007-07-26 |
| IL177052A0 (en) | 2006-12-10 |
| NO20063963L (no) | 2006-09-05 |
| CN1917860A (zh) | 2007-02-21 |
| KR20060132891A (ko) | 2006-12-22 |
| ECSP066827A (es) | 2006-11-24 |
| PE20050771A1 (es) | 2005-11-15 |
| AR050230A1 (es) | 2006-10-11 |
| US20050175698A1 (en) | 2005-08-11 |
| RU2006127437A (ru) | 2008-03-20 |
| TW200528092A (en) | 2005-09-01 |
| SG149894A1 (en) | 2009-02-27 |
| WO2005077340A1 (en) | 2005-08-25 |
| AU2005212166A1 (en) | 2005-08-25 |
| PA8622601A1 (es) | 2005-10-28 |
| EP1711167A1 (en) | 2006-10-18 |
| ZA200606526B (en) | 2010-03-31 |
| BRPI0507372A (pt) | 2007-07-10 |
| CR8535A (es) | 2006-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |