CA2543058A1 - Mouches transgeniques exprimant un mutant a.beta.42 - Google Patents

Mouches transgeniques exprimant un mutant a.beta.42 Download PDF

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Publication number
CA2543058A1
CA2543058A1 CA002543058A CA2543058A CA2543058A1 CA 2543058 A1 CA2543058 A1 CA 2543058A1 CA 002543058 A CA002543058 A CA 002543058A CA 2543058 A CA2543058 A CA 2543058A CA 2543058 A1 CA2543058 A1 CA 2543058A1
Authority
CA
Canada
Prior art keywords
fly
transgenic
phenotype
transgenic fly
drosophila
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002543058A
Other languages
English (en)
Inventor
David A. Lowe
Christopher J. Cummings
Gerhard Koenig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vitruvean LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/853,593 external-priority patent/US20040250302A1/en
Priority claimed from US10/852,974 external-priority patent/US20050108779A1/en
Priority claimed from US10/852,973 external-priority patent/US20040255342A1/en
Priority claimed from US10/852,892 external-priority patent/US20040244064A1/en
Priority claimed from US10/852,951 external-priority patent/US20040255341A1/en
Application filed by Individual filed Critical Individual
Publication of CA2543058A1 publication Critical patent/CA2543058A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
    • A01K67/0333—Genetically modified invertebrates, e.g. transgenic, polyploid
    • A01K67/0337—Genetically modified Arthropods
    • A01K67/0339—Genetically modified insects, e.g. Drosophila melanogaster, medfly
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/70—Invertebrates
    • A01K2227/706—Insects, e.g. Drosophila melanogaster, medfly
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
CA002543058A 2003-10-20 2004-10-21 Mouches transgeniques exprimant un mutant a.beta.42 Abandoned CA2543058A1 (fr)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US51291303P 2003-10-20 2003-10-20
US51314903P 2003-10-21 2003-10-21
US51315203P 2003-10-21 2003-10-21
US51297203P 2003-10-21 2003-10-21
US51297003P 2003-10-21 2003-10-21
US60/513,149 2003-10-21
US60/512,972 2003-10-21
US60/513,152 2003-10-21
US60/512,970 2003-10-21
US60/512,913 2003-10-21
US10/852,973 2004-05-25
US10/852,892 2004-05-25
US10/853,593 US20040250302A1 (en) 2003-10-21 2004-05-25 Transgenic flies expressing Abeta42-dutch
US10/852,974 US20050108779A1 (en) 2003-10-21 2004-05-25 Transgenic flies expressing Abeta42-Italian
US10/852,974 2004-05-25
US10/853,593 2004-05-25
US10/852,973 US20040255342A1 (en) 2003-10-21 2004-05-25 Transgenic flies expressing Abeta42-Iowa
US10/852,892 US20040244064A1 (en) 2003-10-20 2004-05-25 Transgenic flies expressing Abeta42-Flemish
US10/852,951 US20040255341A1 (en) 2003-10-21 2004-05-25 Transgenic flies expressing Abeta42-Arctic
US10/852,951 2004-05-25
PCT/US2004/034838 WO2005041650A1 (fr) 2003-10-20 2004-10-21 Mouches transgeniques exprimant un mutant a$g(b)42

Publications (1)

Publication Number Publication Date
CA2543058A1 true CA2543058A1 (fr) 2005-05-12

Family

ID=34557951

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002543058A Abandoned CA2543058A1 (fr) 2003-10-20 2004-10-21 Mouches transgeniques exprimant un mutant a.beta.42

Country Status (4)

Country Link
EP (1) EP1684574A4 (fr)
AU (1) AU2004284937A1 (fr)
CA (1) CA2543058A1 (fr)
WO (1) WO2005041650A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
KR101439828B1 (ko) 2005-11-30 2014-09-17 애브비 인코포레이티드 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도
AU2006319358B2 (en) 2005-11-30 2012-01-19 AbbVie Deutschland GmbH & Co. KG Anti-Abeta globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
WO2007064917A2 (fr) * 2005-11-30 2007-06-07 Abbott Laboratories Procedes de preparation de formes recombinees de la proteine beta-amyloide humaine et utilisation desdites proteines
JP2009539406A (ja) * 2006-06-16 2009-11-19 エンビボ ファーマシューティカルズ インコーポレイテッド タウおよびアミロイド前駆体断片を発現する遺伝子組換えハエ
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
WO2008104386A2 (fr) 2007-02-27 2008-09-04 Abbott Gmbh & Co. Kg Méthode de traitement d'amyloïdoses
CA2796339C (fr) 2010-04-15 2020-03-31 Abbott Laboratories Proteines de liaison a la beta amyloide
EP3533803B1 (fr) 2010-08-14 2021-10-27 AbbVie Inc. Anticorps anti-bêta-amyloïde
GB201603654D0 (en) * 2016-03-02 2016-04-13 Parkure Ltd Screening assay
JP6870852B2 (ja) * 2017-05-19 2021-05-12 国立研究開発法人国立長寿医療研究センター 遺伝子組換え無脊椎動物アルツハイマー病モデルおよびその利用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69229718D1 (de) * 1992-03-20 1999-09-09 Innogenetics Nv Mutierte Form von dem Beta-Amyloidprecursor Proteine Gen
CA2414772C (fr) * 2000-07-07 2011-06-28 Jan Naslund Prevention et traitement de la maladie d'alzheimer
US6900367B2 (en) * 2000-09-29 2005-05-31 Novartis Transgenic Drosophila melanogaster expressing a β42 in the eye
US20040194158A1 (en) * 2003-03-28 2004-09-30 Baylor College Of Medicine Model for neurodegenerative disorders
US20050043264A1 (en) * 2003-07-01 2005-02-24 Jyh-Lyh Juang Methods of inhibiting neurodegenerative disease

Also Published As

Publication number Publication date
EP1684574A4 (fr) 2008-08-06
EP1684574A1 (fr) 2006-08-02
AU2004284937A1 (en) 2005-05-12
WO2005041650A1 (fr) 2005-05-12

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20121022