CA2540543A1 - Tetrahydropyridine derivatives - Google Patents
Tetrahydropyridine derivatives Download PDFInfo
- Publication number
- CA2540543A1 CA2540543A1 CA002540543A CA2540543A CA2540543A1 CA 2540543 A1 CA2540543 A1 CA 2540543A1 CA 002540543 A CA002540543 A CA 002540543A CA 2540543 A CA2540543 A CA 2540543A CA 2540543 A1 CA2540543 A1 CA 2540543A1
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- heteroaryl
- mmol
- chloro
- renal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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Landscapes
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
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- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
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- Emergency Medicine (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0311146 | 2003-10-09 | ||
| EPPCT/EP03/11146 | 2003-10-09 | ||
| PCT/EP2004/011088 WO2005040120A1 (en) | 2003-10-09 | 2004-10-05 | Tetrahydropyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2540543A1 true CA2540543A1 (en) | 2005-05-06 |
Family
ID=34486009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002540543A Abandoned CA2540543A1 (en) | 2003-10-09 | 2004-10-05 | Tetrahydropyridine derivatives |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080234305A1 (enExample) |
| JP (1) | JP2007508260A (enExample) |
| CN (1) | CN1863773A (enExample) |
| AU (1) | AU2004283814A1 (enExample) |
| CA (1) | CA2540543A1 (enExample) |
| WO (1) | WO2005040120A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2577084A1 (en) * | 2004-08-25 | 2006-03-02 | Olivier Bezencon | Bicyclononene derivatives as renin inhibitors |
| GB0500784D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| CA2615048A1 (en) * | 2005-07-22 | 2007-01-25 | Merck Frosst Canada Ltd. | Renin inhibitors |
| JP5306821B2 (ja) | 2005-12-30 | 2013-10-02 | ノバルティス アーゲー | レニン阻害剤としての３，５−置換ピペリジン化合物 |
| CA2642424A1 (en) * | 2006-03-03 | 2007-09-07 | Actelion Pharmaceuticals Ltd. | Primary amines as renin inhibitors |
| NZ571595A (en) * | 2006-03-08 | 2010-06-25 | Actelion Pharmaceuticals Ltd | New amines |
| EP1908471A1 (en) * | 2006-10-04 | 2008-04-09 | Speedel Experimenta AG | Tetrahydropyridines as renin inhibitors |
| AU2008253519A1 (en) | 2007-05-24 | 2008-11-27 | Merck Frosst Canada Ltd | Novel case of renin inhibitors |
| NZ582098A (en) | 2007-06-25 | 2012-03-30 | Novartis Ag | N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors |
| EP2190811B1 (en) | 2007-08-20 | 2013-08-07 | Merck Canada Inc. | Renin inhibitors |
| WO2009071448A1 (en) | 2007-12-05 | 2009-06-11 | Basf Se | Pyridylmethyl-sulfonamide compounds |
| KR101247840B1 (ko) | 2008-02-22 | 2013-03-26 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타 조절제 |
| US8889714B2 (en) | 2008-05-05 | 2014-11-18 | Actelion Pharmaceuticals Ltd. | 3,4-substituted piperidine derivatives as renin inhibitors |
| JP5502089B2 (ja) | 2008-10-09 | 2014-05-28 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドβのモジュレーター |
| CN102209537A (zh) | 2008-11-10 | 2011-10-05 | 弗·哈夫曼-拉罗切有限公司 | 杂环γ分泌酶调节剂 |
| WO2010090875A1 (en) | 2009-01-21 | 2010-08-12 | Rigel Pharmaceuticals, Inc. | Derivatives of n2-(3-pyridil or phenyl)-n4-(4-piperidyl)-2,4-pyrimidinediamine useful in the treatment of inflammatory, autoimmune or proliferative diseases |
| CN101696187B (zh) * | 2009-09-30 | 2011-09-07 | 徐州工业职业技术学院 | N-取代基-1,2,3,6-四氢吡啶的合成方法 |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| WO2012066488A2 (en) | 2010-11-17 | 2012-05-24 | Actelion Pharmaceuticals Ltd | Bridged spiro[2.4]heptane ester derivatives |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
| KR100879647B1 (ko) * | 2000-03-06 | 2009-01-20 | 아카디아 파마슈티칼스 인코포레이티드 | 세로토닌 관련 질병의 치료에 사용되는 아자시클릭 화합물 |
| US20030013883A1 (en) * | 2000-06-16 | 2003-01-16 | Tamagnan Gilles D. | Tropane analogs binding to monoamine transporters |
| KR100783863B1 (ko) * | 2002-04-29 | 2007-12-10 | 액테리온 파마슈티칼 리미티드 | 7-아릴-3,9-디아자바이사이클로(3.3.1)논-6-엔 유도체 및고혈압, 심혈관 질환 또는 신장 질환의 치료에서 레닌저해물질로써 이들의 용도 |
| MXPA04012136A (es) * | 2002-06-27 | 2005-04-19 | Actelion Pharmaceuticals Ltd | Nuevos derivados de tetrahidropiridina como inhibidores de renina. |
-
2004
- 2004-10-05 CN CNA2004800293878A patent/CN1863773A/zh active Pending
- 2004-10-05 WO PCT/EP2004/011088 patent/WO2005040120A1/en not_active Ceased
- 2004-10-05 AU AU2004283814A patent/AU2004283814A1/en not_active Abandoned
- 2004-10-05 US US10/575,348 patent/US20080234305A1/en not_active Abandoned
- 2004-10-05 JP JP2006530088A patent/JP2007508260A/ja active Pending
- 2004-10-05 CA CA002540543A patent/CA2540543A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005040120A1 (en) | 2005-05-06 |
| CN1863773A (zh) | 2006-11-15 |
| AU2004283814A1 (en) | 2005-05-06 |
| JP2007508260A (ja) | 2007-04-05 |
| US20080234305A1 (en) | 2008-09-25 |
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