CA2539976A1 - Therapeutic beta aminoacids - Google Patents
Therapeutic beta aminoacids Download PDFInfo
- Publication number
- CA2539976A1 CA2539976A1 CA002539976A CA2539976A CA2539976A1 CA 2539976 A1 CA2539976 A1 CA 2539976A1 CA 002539976 A CA002539976 A CA 002539976A CA 2539976 A CA2539976 A CA 2539976A CA 2539976 A1 CA2539976 A1 CA 2539976A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- methyl
- phenyl
- acid
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 150000001576 beta-amino acids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 179
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- 208000035475 disorder Diseases 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims description 83
- 125000001153 fluoro group Chemical group F* 0.000 claims description 57
- -1 phenyl-(C1-C3)alkyl Chemical group 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 37
- 239000001257 hydrogen Substances 0.000 claims description 37
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 30
- 125000004076 pyridyl group Chemical group 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 29
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 25
- 241000124008 Mammalia Species 0.000 claims description 24
- 125000001424 substituent group Chemical group 0.000 claims description 20
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 16
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 11
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 9
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- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 13
- 230000007062 hydrolysis Effects 0.000 description 13
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- 239000010410 layer Substances 0.000 description 12
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 10
- 229940086542 triethylamine Drugs 0.000 description 10
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- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
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- 238000005292 vacuum distillation Methods 0.000 description 1
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Classifications
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
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- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50600303P | 2003-09-25 | 2003-09-25 | |
| US60/506,003 | 2003-09-25 | ||
| PCT/IB2004/002978 WO2005030184A2 (en) | 2003-09-25 | 2004-09-13 | Therapeutic beta aminoacids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2539976A1 true CA2539976A1 (en) | 2005-04-07 |
Family
ID=34393101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002539976A Abandoned CA2539976A1 (en) | 2003-09-25 | 2004-09-13 | Therapeutic beta aminoacids |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7112610B2 (enExample) |
| EP (1) | EP1670452A2 (enExample) |
| JP (1) | JP2007506726A (enExample) |
| KR (1) | KR100774625B1 (enExample) |
| CN (1) | CN1856301A (enExample) |
| AU (1) | AU2004275572A1 (enExample) |
| BR (1) | BRPI0414798A (enExample) |
| CA (1) | CA2539976A1 (enExample) |
| IL (1) | IL173862A0 (enExample) |
| MX (1) | MXPA06003381A (enExample) |
| NO (1) | NO20061801L (enExample) |
| RU (2) | RU2344121C2 (enExample) |
| TW (1) | TW200511989A (enExample) |
| WO (1) | WO2005030184A2 (enExample) |
| ZA (1) | ZA200602450B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP5974084B2 (ja) | 2011-05-17 | 2016-08-23 | プリンシピア バイオファーマ インコーポレイテッド | チロシンキナーゼ阻害剤 |
| ES2770550T3 (es) | 2011-05-17 | 2020-07-02 | Univ California | Inhibidores de quinasa |
| US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
| SI3181567T1 (sl) | 2012-09-10 | 2019-09-30 | Principia Biopharma Inc. | Spojine pirazolopirimidina, kot inhibitorji kinaze |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| CN106456652B (zh) | 2014-02-21 | 2020-09-11 | 普林斯匹亚生物制药公司 | Btk抑制剂的盐和固体形式 |
| PT3233103T (pt) | 2014-12-18 | 2021-01-18 | Principia Biopharma Inc | Tratamento de pênfigo |
| US20180305350A1 (en) | 2015-06-24 | 2018-10-25 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| KR102391693B1 (ko) | 2016-06-29 | 2022-04-29 | 프린시피아 바이오파마, 인코퍼레이티드 | 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제 |
| CN115209899A (zh) | 2019-10-14 | 2022-10-18 | 普林斯匹亚生物制药公司 | 通过施用(R)-2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁-3-基)哌嗪-1-基]戊-2-烯腈治疗免疫性血小板减少症的方法 |
| EP4093741A1 (en) | 2020-01-22 | 2022-11-30 | Principia Biopharma Inc. | Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2256370T3 (es) * | 1991-08-23 | 2006-07-16 | Nps Pharmaceuticals, Inc. | Moleculas activas para el receptor de calcio. |
| US6306909B1 (en) * | 1997-03-12 | 2001-10-23 | Queen's University At Kingston | Anti-epileptogenic agents |
| FR2791982B1 (fr) * | 1999-04-06 | 2002-12-27 | Inst Nat Sante Rech Med | Inhibiteurs de lta4 hydrolase et leurs applications therapeutiques. |
| IL157845A0 (en) * | 2001-03-13 | 2004-03-28 | Univ Kingston | Anti-epileptogenic agents |
| NI200300043A (es) * | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
| GB0219024D0 (en) * | 2002-08-15 | 2002-09-25 | Pfizer Ltd | Synergistic combinations |
| CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| US20050043345A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US20050043407A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US20050043406A1 (en) * | 2003-08-22 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
-
2004
- 2004-09-13 CA CA002539976A patent/CA2539976A1/en not_active Abandoned
- 2004-09-13 EP EP04769367A patent/EP1670452A2/en not_active Withdrawn
- 2004-09-13 RU RU2006107650/04A patent/RU2344121C2/ru not_active IP Right Cessation
- 2004-09-13 CN CNA2004800277659A patent/CN1856301A/zh active Pending
- 2004-09-13 MX MXPA06003381A patent/MXPA06003381A/es unknown
- 2004-09-13 BR BRPI0414798-7A patent/BRPI0414798A/pt not_active IP Right Cessation
- 2004-09-13 JP JP2006527499A patent/JP2007506726A/ja not_active Withdrawn
- 2004-09-13 AU AU2004275572A patent/AU2004275572A1/en not_active Abandoned
- 2004-09-13 KR KR1020067005783A patent/KR100774625B1/ko not_active Expired - Fee Related
- 2004-09-13 WO PCT/IB2004/002978 patent/WO2005030184A2/en not_active Ceased
- 2004-09-24 US US10/950,094 patent/US7112610B2/en not_active Expired - Fee Related
- 2004-09-24 TW TW093129003A patent/TW200511989A/zh unknown
-
2006
- 2006-02-21 IL IL173862A patent/IL173862A0/en unknown
- 2006-03-24 ZA ZA200602450A patent/ZA200602450B/en unknown
- 2006-04-24 NO NO20061801A patent/NO20061801L/no not_active Application Discontinuation
- 2006-06-30 US US11/480,010 patent/US20060247282A1/en not_active Abandoned
-
2008
- 2008-09-19 RU RU2008137379/04A patent/RU2008137379A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060056391A (ko) | 2006-05-24 |
| IL173862A0 (en) | 2006-07-05 |
| MXPA06003381A (es) | 2006-06-08 |
| US7112610B2 (en) | 2006-09-26 |
| WO2005030184A2 (en) | 2005-04-07 |
| JP2007506726A (ja) | 2007-03-22 |
| KR100774625B1 (ko) | 2007-11-08 |
| WO2005030184A3 (en) | 2005-06-02 |
| ZA200602450B (en) | 2007-09-26 |
| US20050124669A1 (en) | 2005-06-09 |
| RU2344121C2 (ru) | 2009-01-20 |
| CN1856301A (zh) | 2006-11-01 |
| TW200511989A (en) | 2005-04-01 |
| NO20061801L (no) | 2006-06-02 |
| EP1670452A2 (en) | 2006-06-21 |
| RU2006107650A (ru) | 2007-10-27 |
| AU2004275572A1 (en) | 2005-04-07 |
| BRPI0414798A (pt) | 2006-11-21 |
| US20060247282A1 (en) | 2006-11-02 |
| RU2008137379A (ru) | 2010-03-27 |
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| AU2005203759B2 (en) | Amino acids with affinity for the alpha-2-delta-protein | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |