CA2539357A1 - Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone - Google Patents
Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone Download PDFInfo
- Publication number
- CA2539357A1 CA2539357A1 CA002539357A CA2539357A CA2539357A1 CA 2539357 A1 CA2539357 A1 CA 2539357A1 CA 002539357 A CA002539357 A CA 002539357A CA 2539357 A CA2539357 A CA 2539357A CA 2539357 A1 CA2539357 A1 CA 2539357A1
- Authority
- CA
- Canada
- Prior art keywords
- vitamin
- parathyroid hormone
- methylene
- group
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000007070 tosylation reaction Methods 0.000 description 1
- 239000006211 transdermal dosage form Substances 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 206010048828 underweight Diseases 0.000 description 1
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- 235000001892 vitamin D2 Nutrition 0.000 description 1
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Classifications
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Rheumatology (AREA)
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- Immunology (AREA)
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- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50450303P | 2003-09-19 | 2003-09-19 | |
| US60/504,503 | 2003-09-19 | ||
| PCT/IB2004/002902 WO2005027915A1 (en) | 2003-09-19 | 2004-09-06 | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2539357A1 true CA2539357A1 (en) | 2005-03-31 |
Family
ID=34375509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002539357A Abandoned CA2539357A1 (en) | 2003-09-19 | 2004-09-06 | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20050065088A1 (enExample) |
| EP (1) | EP1667689A1 (enExample) |
| JP (1) | JP2007505883A (enExample) |
| KR (1) | KR20060058133A (enExample) |
| CN (1) | CN1852716A (enExample) |
| AU (1) | AU2004273660B2 (enExample) |
| BR (1) | BRPI0414518A (enExample) |
| CA (1) | CA2539357A1 (enExample) |
| IL (1) | IL174144A0 (enExample) |
| MX (1) | MXPA06003064A (enExample) |
| NO (1) | NO20061236L (enExample) |
| NZ (1) | NZ545803A (enExample) |
| RU (1) | RU2006108557A (enExample) |
| TW (1) | TW200511999A (enExample) |
| WO (1) | WO2005027915A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7122533B2 (en) * | 1999-11-29 | 2006-10-17 | The United States Of America As Represented By The Department Of Health And Human Services | Cosalane compounds and methods for their use |
| WO2005051323A2 (en) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
| WO2005051396A2 (en) * | 2003-11-25 | 2005-06-09 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
| CA2597624C (en) * | 2005-02-11 | 2012-08-14 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20s-24s)-1.alpha.,25-dihydroxyvitamin-d2 |
| US7511030B2 (en) * | 2005-02-11 | 2009-03-31 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20S-24epi)-1α,25-dihydroxyvitamin D2 |
| WO2006105221A1 (en) * | 2005-03-29 | 2006-10-05 | Wisconsin Alumni Research Foundation | 2-METHYLENE-19-NOR-(23S)-25-DEHYDRO-1α-HYDROXYVITAMIN D3-26,23-LACTONE AND 2-METHYLENE-19-NOR-(23R)-25-DEHYDRO-1α-HYDROXYVITAMIN D3-26,23-LACTONE |
| US20110237557A1 (en) * | 2010-03-23 | 2011-09-29 | Deluca Hector F | Diastereomers of 2-methylene-19-nor-22-methyl-1alpha,25-dihydroxyvitamin d3 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| US8604009B2 (en) | 2010-03-23 | 2013-12-10 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22-dimethyl-1α,25-hydroxyvitamin D3 |
| WO2015050160A1 (ja) * | 2013-10-03 | 2015-04-09 | 国立大学法人大阪大学 | 副甲状腺ホルモンまたはその誘導体を有効成分とする筋の老化防止用医薬組成物 |
| WO2015064585A1 (ja) * | 2013-10-29 | 2015-05-07 | 国立大学法人熊本大学 | 筋疾患の治療または予防のための医薬組成物 |
| KR20200053069A (ko) * | 2018-11-07 | 2020-05-18 | 주식회사 노브메타파마 | 시클로-히스프로를 유효성분으로 포함하는 비만 예방 또는 치료용 약제학적 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL78342A (en) * | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP2898882B2 (ja) * | 1993-04-05 | 1999-06-02 | ウイスコンシン アラムナイ リサーチ フオンデーシヨン | ２−位に置換基を有する１９−ノル−ビタミンｄ３ 化合物 |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| EP1295605A3 (en) * | 1998-08-19 | 2003-10-29 | Eli Lilly And Company | Method of increasing bone toughness and stiffness and reducing fractures |
| AR033639A1 (es) * | 1998-08-19 | 2004-01-07 | Lilly Co Eli | Uso de hormonas paratiroideas para preparar medicamentos para reducir el riesgo de fracturas oseas vertebrales o no vertebrales en seres humanos con riesgo de padecer o que padecen osteoporosis |
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2004
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- 2004-09-06 KR KR1020067005457A patent/KR20060058133A/ko not_active Ceased
- 2004-09-06 EP EP04769301A patent/EP1667689A1/en not_active Withdrawn
- 2004-09-06 AU AU2004273660A patent/AU2004273660B2/en not_active Expired - Fee Related
- 2004-09-06 WO PCT/IB2004/002902 patent/WO2005027915A1/en not_active Ceased
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- 2004-09-06 NZ NZ545803A patent/NZ545803A/en unknown
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2006
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Also Published As
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| IL174144A0 (en) | 2006-08-01 |
| AU2004273660B2 (en) | 2010-08-19 |
| AU2004273660A1 (en) | 2005-03-31 |
| MXPA06003064A (es) | 2006-05-31 |
| CN1852716A (zh) | 2006-10-25 |
| JP2007505883A (ja) | 2007-03-15 |
| WO2005027915A1 (en) | 2005-03-31 |
| NZ545803A (en) | 2008-03-28 |
| KR20060058133A (ko) | 2006-05-29 |
| TW200511999A (en) | 2005-04-01 |
| RU2006108557A (ru) | 2007-09-27 |
| US20050065088A1 (en) | 2005-03-24 |
| NO20061236L (no) | 2006-06-15 |
| EP1667689A1 (en) | 2006-06-14 |
| BRPI0414518A (pt) | 2006-11-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |