CA2539064A1 - Identification d'inhibiteurs de kinase - Google Patents

Identification d'inhibiteurs de kinase Download PDF

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Publication number
CA2539064A1
CA2539064A1 CA002539064A CA2539064A CA2539064A1 CA 2539064 A1 CA2539064 A1 CA 2539064A1 CA 002539064 A CA002539064 A CA 002539064A CA 2539064 A CA2539064 A CA 2539064A CA 2539064 A1 CA2539064 A1 CA 2539064A1
Authority
CA
Canada
Prior art keywords
kinase
ligand
group
protein kinase
target protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002539064A
Other languages
English (en)
Inventor
John C. Prescott
Andrew Braisted (Deceased)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc filed Critical Sunesis Pharmaceuticals Inc
Publication of CA2539064A1 publication Critical patent/CA2539064A1/fr
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention se rapporte à l'identification d'inhibiteurs de protéines kinases qui se lient de manière préférentielle à la conformation inactive d'une protéine kinase cible. Ces inhibiteurs sont identifiés par verrouillage de la protéine kinase cible dans une conformation inactive, et par un ancrage permettant d'identifier les inhibiteurs ciblant de manière préférentielle la conformation inactive.
CA002539064A 2003-09-17 2003-09-17 Identification d'inhibiteurs de kinase Abandoned CA2539064A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/029870 WO2005034840A2 (fr) 2003-09-17 2003-09-17 Identification d'inhibiteurs de kinase

Publications (1)

Publication Number Publication Date
CA2539064A1 true CA2539064A1 (fr) 2005-04-21

Family

ID=34434214

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002539064A Abandoned CA2539064A1 (fr) 2003-09-17 2003-09-17 Identification d'inhibiteurs de kinase

Country Status (4)

Country Link
EP (1) EP1670422A4 (fr)
AU (1) AU2003270848A1 (fr)
CA (1) CA2539064A1 (fr)
WO (1) WO2005034840A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713973B2 (en) 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
SG179172A1 (en) * 2009-09-16 2012-04-27 Avila Therapeutics Inc Protein kinase conjugates and inhibitors
SG181965A1 (en) 2009-12-30 2012-08-30 Avila Therapeutics Inc Ligand-directed covalent modification of protein
ES2873933T3 (es) * 2010-06-09 2021-11-04 Dana Farber Cancer Inst Inc Una mutación de MEK1 que confiere resistencia a inhibidores de RAF y de MEK
GB201614152D0 (en) 2016-08-18 2016-10-05 Imp Innovations Ltd Assay
US20220265669A1 (en) * 2019-02-25 2022-08-25 Albert Einstein College Of Medicine Compounds useful for inhibiting raf dimers
CN116434828B (zh) * 2023-04-17 2024-03-26 深圳新锐基因科技有限公司 基于计算结构生物学的蛋白分子动态二硫键的引入方法及装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE420366T1 (de) * 2000-11-21 2009-01-15 Sunesis Pharmaceuticals Inc ERWEITERTER ßTETHERINGß ANSATZ ZUM SCHNELLEN AUFFINDEN VON LIGANDEN
JP2005503380A (ja) * 2001-08-07 2005-02-03 サネシス ファーマシューティカルズ， インコーポレイテッド システイン変異体および生物学的分子に結合するリガンドを検出するための方法
CA2478981A1 (fr) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification d'inhibiteurs de kinase

Also Published As

Publication number Publication date
WO2005034840A8 (fr) 2006-04-20
EP1670422A4 (fr) 2007-08-01
EP1670422A2 (fr) 2006-06-21
WO2005034840A2 (fr) 2005-04-21
WO2005034840A3 (fr) 2006-10-05
AU2003270848A1 (en) 2005-04-27

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Legal Events

Date Code Title Description
FZDE Discontinued