CA2536936A1 - E- and k-coiled-coil fusion proteins comprising tgf-b cell receptor domains - Google Patents

E- and k-coiled-coil fusion proteins comprising tgf-b cell receptor domains Download PDF

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Publication number
CA2536936A1
CA2536936A1 CA002536936A CA2536936A CA2536936A1 CA 2536936 A1 CA2536936 A1 CA 2536936A1 CA 002536936 A CA002536936 A CA 002536936A CA 2536936 A CA2536936 A CA 2536936A CA 2536936 A1 CA2536936 A1 CA 2536936A1
Authority
CA
Canada
Prior art keywords
coil
coiled
protein
fusion protein
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002536936A
Other languages
English (en)
French (fr)
Inventor
Gregory De Crescenzo
Maureen D. O'connor
Beatrice Paul-Roc
John Zwaagstra
Myriam Banville
Maria Jaramillo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council Of Canada
Gregory De Crescenzo
Maureen D. O'connor
Beatrice Paul-Roc
John Zwaagstra
Myriam Banville
Maria Jaramillo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council Of Canada, Gregory De Crescenzo, Maureen D. O'connor, Beatrice Paul-Roc, John Zwaagstra, Myriam Banville, Maria Jaramillo filed Critical National Research Council Of Canada
Publication of CA2536936A1 publication Critical patent/CA2536936A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002536936A 2003-09-05 2004-09-02 E- and k-coiled-coil fusion proteins comprising tgf-b cell receptor domains Abandoned CA2536936A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50085503P 2003-09-05 2003-09-05
US60/500,855 2003-09-05
PCT/CA2004/001616 WO2005024035A1 (en) 2003-09-05 2004-09-02 Coiled-coil fusion proteins comprising cell receptor domains

Publications (1)

Publication Number Publication Date
CA2536936A1 true CA2536936A1 (en) 2005-03-17

Family

ID=34273005

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002536936A Abandoned CA2536936A1 (en) 2003-09-05 2004-09-02 E- and k-coiled-coil fusion proteins comprising tgf-b cell receptor domains

Country Status (5)

Country Link
EP (1) EP1668133A4 (ja)
JP (1) JP2007503820A (ja)
AU (1) AU2004270774A1 (ja)
CA (1) CA2536936A1 (ja)
WO (1) WO2005024035A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012071649A1 (en) * 2010-11-29 2012-06-07 National Research Council Of Canada Covalently dimerized bivalent binding agents

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070184052A1 (en) * 2003-05-09 2007-08-09 Lin Herbert Y Soluble tgf-b type III receptor fusion proteins
US7710853B2 (en) 2004-03-18 2010-05-04 Lg Electronics, Inc. Recording medium with segment information thereon and apparatus and methods for forming, recording, and reproducing the recording medium
JP4610607B2 (ja) 2004-03-18 2011-01-12 エルジー エレクトロニクス インコーポレイティド 記録媒体へ／からデータを記録／再生するための方法および装置
TWI381374B (zh) 2004-03-18 2013-01-01 Lg Electronics Inc 其上具有重疊區塊資訊之記錄媒體和用以形成、記錄及重製記錄媒體之設備和方法
EP2491391B1 (en) * 2009-10-23 2018-02-28 GE Healthcare Bio-Sciences AB Method for determination of macromolecular multimers
JP7079779B2 (ja) * 2016-11-18 2022-06-02 ユニバーシティ オブ ピッツバーグ － オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 操作されたｔｇｆベータ単量体およびｔｇｆベータシグナル伝達のためのそれらの使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012988A1 (en) * 1995-10-06 1997-04-10 Pence Coiled-coil heterodimer methods and compositions for the detection and purification of expressed proteins
US6472179B2 (en) * 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
EP1153295A2 (en) * 1999-02-11 2001-11-14 Xencor, Inc. Structure-based screening techniques for drug discovery

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012071649A1 (en) * 2010-11-29 2012-06-07 National Research Council Of Canada Covalently dimerized bivalent binding agents
US8987417B2 (en) 2010-11-29 2015-03-24 National Research Council Of Canada Covalently dimerized bivalent binding agents

Also Published As

Publication number Publication date
EP1668133A1 (en) 2006-06-14
AU2004270774A1 (en) 2005-03-17
EP1668133A4 (en) 2007-08-29
WO2005024035A1 (en) 2005-03-17
JP2007503820A (ja) 2007-03-01

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Legal Events

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EEER Examination request
FZDE Dead

Effective date: 20160111