CA2536181A1 - Polymer compositions and methods for their use - Google Patents
Polymer compositions and methods for their use Download PDFInfo
- Publication number
- CA2536181A1 CA2536181A1 CA002536181A CA2536181A CA2536181A1 CA 2536181 A1 CA2536181 A1 CA 2536181A1 CA 002536181 A CA002536181 A CA 002536181A CA 2536181 A CA2536181 A CA 2536181A CA 2536181 A1 CA2536181 A1 CA 2536181A1
- Authority
- CA
- Canada
- Prior art keywords
- fibrotic agent
- polymer
- reactants
- agent
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims 1889
- 229920000642 polymer Polymers 0.000 title claims 568
- 239000000203 mixture Substances 0.000 title claims 62
- 239000003795 chemical substances by application Substances 0.000 claims 1183
- 230000003510 anti-fibrotic effect Effects 0.000 claims 1148
- 239000000376 reactant Substances 0.000 claims 516
- 150000001875 compounds Chemical class 0.000 claims 247
- 229960005475 antiinfective agent Drugs 0.000 claims 140
- 239000004599 antimicrobial Substances 0.000 claims 140
- 108010035532 Collagen Proteins 0.000 claims 130
- 102000008186 Collagen Human genes 0.000 claims 130
- 229920001436 collagen Polymers 0.000 claims 130
- 239000003112 inhibitor Substances 0.000 claims 126
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 68
- 239000005557 antagonist Substances 0.000 claims 56
- 102000004169 proteins and genes Human genes 0.000 claims 56
- 108090000623 proteins and genes Proteins 0.000 claims 56
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 54
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 52
- 210000001519 tissue Anatomy 0.000 claims 49
- 125000003277 amino group Chemical group 0.000 claims 48
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 48
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 42
- 108010039918 Polylysine Proteins 0.000 claims 28
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- 230000015572 biosynthetic process Effects 0.000 claims 28
- 229940043355 kinase inhibitor Drugs 0.000 claims 28
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical group COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 claims 28
- 229920000656 polylysine Polymers 0.000 claims 28
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 27
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 27
- 235000014655 lactic acid Nutrition 0.000 claims 26
- 239000004310 lactic acid Substances 0.000 claims 26
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 24
- -1 poly(ethylene glycol) Polymers 0.000 claims 24
- 229920001059 synthetic polymer Polymers 0.000 claims 22
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 21
- 229940123034 Heat shock protein 90 antagonist Drugs 0.000 claims 21
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical group C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 21
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- YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 claims 21
- 238000003786 synthesis reaction Methods 0.000 claims 21
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 21
- PGEGFAGJACEMIS-UHFFFAOYSA-N carbon dioxide;pyrrolidine-2,5-dione Chemical group O=C=O.O=C1CCC(=O)N1 PGEGFAGJACEMIS-UHFFFAOYSA-N 0.000 claims 20
- WAVYAFBQOXCGSZ-UHFFFAOYSA-N 2-fluoropyrimidine Chemical group FC1=NC=CC=N1 WAVYAFBQOXCGSZ-UHFFFAOYSA-N 0.000 claims 14
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical group NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 14
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- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 14
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- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical group NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 14
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- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 14
- GYOZYWVXFNDGLU-XLPZGREQSA-N dTMP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)C1 GYOZYWVXFNDGLU-XLPZGREQSA-N 0.000 claims 14
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 14
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 14
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- 229920000159 gelatin Polymers 0.000 claims 14
- 239000008273 gelatin Substances 0.000 claims 14
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- 229960001330 hydroxycarbamide Drugs 0.000 claims 14
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- 239000002307 peroxisome proliferator activated receptor agonist Substances 0.000 claims 14
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 14
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- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 14
- 229960001967 tacrolimus Drugs 0.000 claims 14
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 14
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 12
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims 12
- 229920001223 polyethylene glycol Polymers 0.000 claims 12
- 210000004204 blood vessel Anatomy 0.000 claims 9
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical group O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 7
- DOEWDSDBFRHVAP-KRXBUXKQSA-N (E)-3-tosylacrylonitrile Chemical group CC1=CC=C(S(=O)(=O)\C=C\C#N)C=C1 DOEWDSDBFRHVAP-KRXBUXKQSA-N 0.000 claims 7
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- YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical group [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 claims 7
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- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 claims 7
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Landscapes
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- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- External Artificial Organs (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52390803P | 2003-11-20 | 2003-11-20 | |
| US60/523,908 | 2003-11-20 | ||
| US52522603P | 2003-11-24 | 2003-11-24 | |
| US60/525,226 | 2003-11-24 | ||
| US52654103P | 2003-12-03 | 2003-12-03 | |
| US60/526,541 | 2003-12-03 | ||
| US56656904P | 2004-04-28 | 2004-04-28 | |
| US60/566,569 | 2004-04-28 | ||
| US58686104P | 2004-07-09 | 2004-07-09 | |
| US60/586,861 | 2004-07-09 | ||
| US61107704P | 2004-09-17 | 2004-09-17 | |
| US60/611,077 | 2004-09-17 | ||
| US10/986,231 US20050181977A1 (en) | 2003-11-10 | 2004-11-10 | Medical implants and anti-scarring agents |
| US10/986,231 | 2004-11-10 | ||
| PCT/US2004/039389 WO2005051452A2 (en) | 2003-11-20 | 2004-11-22 | Polymer compositions and methods for their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2536181A1 true CA2536181A1 (en) | 2005-06-09 |
Family
ID=34637499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002536181A Abandoned CA2536181A1 (en) | 2003-11-20 | 2004-11-22 | Polymer compositions and methods for their use |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1684819A2 (enExample) |
| JP (1) | JP2007517543A (enExample) |
| AU (1) | AU2004293071A1 (enExample) |
| CA (1) | CA2536181A1 (enExample) |
| IL (1) | IL174641A0 (enExample) |
| WO (2) | WO2005051452A2 (enExample) |
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| WO2006137222A1 (ja) * | 2005-06-24 | 2006-12-28 | Tokyo Medical And Dental University | 薬剤溶出速度制御方法、及び薬剤溶出性ステント被膜用組成物 |
| JP2007135965A (ja) * | 2005-11-21 | 2007-06-07 | Tohoku Univ | 体内留置多機能ステントおよびその製造方法 |
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| CN115382028A (zh) * | 2022-09-19 | 2022-11-25 | 郑州大学第一附属医院 | 一种可降解吻合器材料及其制备方法和应用 |
| WO2024159015A1 (en) * | 2023-01-25 | 2024-08-02 | North Carolina State University | Compositions and methods relating to inhalable therapeutic compositions |
| JP7602090B1 (ja) * | 2024-06-10 | 2024-12-17 | 真由美 大石 | 生体組織の瘢痕化を抑制するための創傷用足場材 |
| CN118903564B (zh) * | 2024-09-02 | 2025-11-04 | 嘉兴睿清医疗科技有限公司 | 一种羟基磷灰石复合聚酯微球及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003520830A (ja) * | 2000-01-25 | 2003-07-08 | エドワーズ ライフサイエンシーズ コーポレイション | 再狭窄および吻合内膜過形成処置のための送達系 |
| JP2004529934A (ja) * | 2001-05-01 | 2004-09-30 | アンジオテック ファーマシューティカルズ，インコーポレイテッド | 抗微小管剤およびポリペプチドまたはポリサッカリドを含む組成物、ならびに炎症状態を処置するための医薬品の調製のためのそれらの組成物の使用 |
| US20030207907A1 (en) * | 2002-05-03 | 2003-11-06 | Iversen Patrick L. | Delivery of microparticle-conjugated drugs for inhibition of stenosis |
| US20050208095A1 (en) * | 2003-11-20 | 2005-09-22 | Angiotech International Ag | Polymer compositions and methods for their use |
-
2004
- 2004-11-22 EP EP04816983A patent/EP1684819A2/en not_active Withdrawn
- 2004-11-22 CA CA002536181A patent/CA2536181A1/en not_active Abandoned
- 2004-11-22 JP JP2006541670A patent/JP2007517543A/ja active Pending
- 2004-11-22 WO PCT/US2004/039389 patent/WO2005051452A2/en not_active Ceased
- 2004-11-22 AU AU2004293071A patent/AU2004293071A1/en not_active Abandoned
- 2004-11-22 WO PCT/US2004/039491 patent/WO2005051316A2/en not_active Ceased
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2006
- 2006-03-30 IL IL174641A patent/IL174641A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005051316A3 (en) | 2010-01-28 |
| JP2007517543A (ja) | 2007-07-05 |
| IL174641A0 (en) | 2006-08-20 |
| WO2005051452A2 (en) | 2005-06-09 |
| EP1684819A2 (en) | 2006-08-02 |
| AU2004293071A1 (en) | 2005-06-09 |
| WO2005051316A2 (en) | 2005-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20160420 |