CA2534643A1 - Methods for screening and identifying compounds - Google Patents
Methods for screening and identifying compounds Download PDFInfo
- Publication number
- CA2534643A1 CA2534643A1 CA002534643A CA2534643A CA2534643A1 CA 2534643 A1 CA2534643 A1 CA 2534643A1 CA 002534643 A CA002534643 A CA 002534643A CA 2534643 A CA2534643 A CA 2534643A CA 2534643 A1 CA2534643 A1 CA 2534643A1
- Authority
- CA
- Canada
- Prior art keywords
- methods
- screening
- identifying compounds
- diabetes
- relates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 238000005192 partition Methods 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000011529 cardiovascular cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49276303P | 2003-08-04 | 2003-08-04 | |
| US60/492,763 | 2003-08-04 | ||
| PCT/US2004/025072 WO2005017187A2 (en) | 2003-08-04 | 2004-08-04 | Methods for screening and identifying compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2534643A1 true CA2534643A1 (en) | 2005-02-24 |
Family
ID=34193146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002534643A Abandoned CA2534643A1 (en) | 2003-08-04 | 2004-08-04 | Methods for screening and identifying compounds |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US6994956B2 (ja) |
| EP (1) | EP1660671A4 (ja) |
| JP (1) | JP2007501012A (ja) |
| CA (1) | CA2534643A1 (ja) |
| WO (1) | WO2005017187A2 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2534643A1 (en) * | 2003-08-04 | 2005-02-24 | Bayer Pharmaceuticals Corporation | Methods for screening and identifying compounds |
| US7384757B2 (en) * | 2004-03-31 | 2008-06-10 | Bristol-Myers Squibb Company | Scintillation proximity assay method of measuring acetyl CoA carboxylase enzyme activity |
| US20080064717A1 (en) * | 2006-05-19 | 2008-03-13 | Rajesh Iyengar | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme |
| US20080015227A1 (en) * | 2006-05-19 | 2008-01-17 | Kym Philip R | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme |
| WO2007147023A1 (en) * | 2006-06-14 | 2007-12-21 | Bristol-Myers Squibb Company | An assay for measuring acyltransferase activity |
| EP2166843A4 (en) | 2007-06-01 | 2010-08-11 | Univ Princeton | TREATMENT OF VIRUS INFECTIONS BY MODULATION OF HOST CELL METABOLISMS |
| AU2009245975A1 (en) * | 2008-05-16 | 2009-11-19 | The Governors Of The University Of Alberta | High throughput methods of identifying neutral lipid synthases |
| WO2010086820A1 (en) | 2009-02-02 | 2010-08-05 | Pfizer Inc. | 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof |
| WO2010089685A1 (en) | 2009-02-03 | 2010-08-12 | Pfizer Inc. | 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives |
| JP2012516885A (ja) | 2009-02-04 | 2012-07-26 | ファイザー・インク | ４−アミノ−７，８−ジヒドロピリド［４，３−ｄ］ピリミジン−５（６Ｈ）−オン誘導体 |
| EP2267152A1 (en) * | 2009-06-26 | 2010-12-29 | Sanofi-Aventis | Test system for measuring MEST activity as well as methods and uses involving the same |
| JP2016513725A (ja) * | 2013-03-15 | 2016-05-16 | ノーモクシス，インコーポレイテッド | 抗肥満薬としてのミオイノシトールトリスピロホスフェート |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US26235A (en) * | 1859-11-22 | Henry m | ||
| US203411A (en) * | 1878-05-07 | Improvement in electric lamps | ||
| US18487A (en) * | 1857-10-20 | badger | ||
| US4372941A (en) * | 1980-09-05 | 1983-02-08 | Ryan James W | Novel radioassay procedure |
| US4563305A (en) * | 1981-01-07 | 1986-01-07 | University Of Miami | Radiolabelled substrates for assaying mammalian enzymes |
| DE59506516D1 (de) * | 1994-09-21 | 1999-09-09 | Koenig & Bauer Ag | Tragzapfen zum Festklemmen von auf Hülsen gewickelten Papierbahnen |
| EP1179340A3 (en) * | 1994-09-30 | 2003-05-07 | INEX Pharmaceutical Corp. | Compositions for the introduction of polyanionic materials into cells |
| US7312041B2 (en) * | 2001-02-16 | 2007-12-25 | Arbor Vita Corporation | Methods of diagnosing cervical cancer |
| US20030203411A1 (en) * | 2001-06-05 | 2003-10-30 | Sabbadini Roger A. | Methods of minicell-based delivery |
| WO2005005977A2 (en) * | 2003-06-30 | 2005-01-20 | Applera Corporation | Fluorescent phospholipase assays and compositions |
| CA2534643A1 (en) * | 2003-08-04 | 2005-02-24 | Bayer Pharmaceuticals Corporation | Methods for screening and identifying compounds |
-
2004
- 2004-08-04 CA CA002534643A patent/CA2534643A1/en not_active Abandoned
- 2004-08-04 JP JP2006522675A patent/JP2007501012A/ja active Pending
- 2004-08-04 EP EP04779988A patent/EP1660671A4/en not_active Withdrawn
- 2004-08-04 WO PCT/US2004/025072 patent/WO2005017187A2/en active Search and Examination
- 2004-08-04 US US10/911,242 patent/US6994956B2/en not_active Expired - Fee Related
-
2005
- 2005-11-02 US US11/266,030 patent/US20060068456A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050064531A1 (en) | 2005-03-24 |
| EP1660671A4 (en) | 2007-09-12 |
| EP1660671A2 (en) | 2006-05-31 |
| WO2005017187A3 (en) | 2005-07-14 |
| US6994956B2 (en) | 2006-02-07 |
| US20060068456A1 (en) | 2006-03-30 |
| JP2007501012A (ja) | 2007-01-25 |
| WO2005017187A2 (en) | 2005-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |
Effective date: 20130806 |