CA2528322C - 2-hydroxymethyl-3,4,5-trihydroxy-1-(4-pentlyoxybenzyl) piperidine as glucosylceramide synthase (gcs) - Google Patents
2-hydroxymethyl-3,4,5-trihydroxy-1-(4-pentlyoxybenzyl) piperidine as glucosylceramide synthase (gcs) Download PDFInfo
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- CA2528322C CA2528322C CA2528322A CA2528322A CA2528322C CA 2528322 C CA2528322 C CA 2528322C CA 2528322 A CA2528322 A CA 2528322A CA 2528322 A CA2528322 A CA 2528322A CA 2528322 C CA2528322 C CA 2528322C
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0313677.7 | 2003-06-13 | ||
| GBGB0313677.7A GB0313677D0 (en) | 2003-06-13 | 2003-06-13 | Novel compound |
| PCT/GB2004/002450 WO2004111001A1 (en) | 2003-06-13 | 2004-06-09 | 2-hydroxymethyl-3,4,5-trihydroxy-1-(4-pentlyoxybenzyl) piperidine as glucosylceramide synthase (gcs) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2528322A1 CA2528322A1 (en) | 2004-12-23 |
| CA2528322C true CA2528322C (en) | 2012-07-31 |
Family
ID=27590018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2528322A Expired - Fee Related CA2528322C (en) | 2003-06-13 | 2004-06-09 | 2-hydroxymethyl-3,4,5-trihydroxy-1-(4-pentlyoxybenzyl) piperidine as glucosylceramide synthase (gcs) |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8022219B2 (enExample) |
| EP (1) | EP1641755B1 (enExample) |
| JP (1) | JP4780784B2 (enExample) |
| CN (1) | CN100422150C (enExample) |
| AU (1) | AU2004247468B2 (enExample) |
| BR (1) | BRPI0411293A8 (enExample) |
| CA (1) | CA2528322C (enExample) |
| ES (1) | ES2391634T3 (enExample) |
| GB (1) | GB0313677D0 (enExample) |
| IL (1) | IL172541A (enExample) |
| WO (1) | WO2004111001A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0100889D0 (en) | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| JP4575156B2 (ja) | 2002-07-17 | 2010-11-04 | アクテリオン ファーマシューティカルズ リミテッド | グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 |
| ES2393919T3 (es) * | 2002-07-17 | 2013-01-02 | Actelion Pharmaceuticals Ltd. | Derivados de PIPERIDINETRIOL como inhibidores de GLUCOSILCERAMIDA SINTASA |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| BRPI0609515A8 (pt) | 2005-03-23 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Composto, composição farmacêutica, e, uso de um composto |
| EP2785335B8 (en) | 2011-11-29 | 2017-08-02 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods and pharmaceutical compositions for the treatment of darier disease |
| EP3377908B1 (en) | 2015-11-18 | 2020-08-05 | Genzyme Corporation | Biomarker of polycystic kidney disease and uses thereof |
| WO2020193746A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival of patients suffering from melanoma |
| EP3966199A4 (en) | 2019-05-10 | 2023-02-01 | Alectos Therapeutics Inc. | NON-LYSOSOMAL GLUCOSYLCERAMIDASE INHIBITORS AND USES THEREOF |
| PH12022552955A1 (en) | 2020-05-07 | 2024-02-26 | Alectos Therapeutics Inc | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| DE3007078A1 (de) * | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
| DE3024901A1 (de) | 1980-07-01 | 1982-01-28 | Bayer Ag, 5090 Leverkusen | Herbizide mittel auf basis von piperidin-derivaten |
| DE3247615A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
| US5003072A (en) * | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
| JPH02306962A (ja) | 1989-05-19 | 1990-12-20 | Meiji Seika Kaisha Ltd | 新規ｎ―置換―１―デオキシノジリマイシン誘導体及びそれを含有する癌細胞転移抑制剤 |
| JPH0324057A (ja) | 1989-06-22 | 1991-02-01 | Tosoh Corp | ポリヒドロキシピペリジン類及びその製造法 |
| CA2065446A1 (en) | 1989-09-07 | 1991-03-08 | Yoshiaki Yoshikuni | Antiviral drug |
| WO1992000277A1 (en) * | 1990-06-29 | 1992-01-09 | Nippon Shinyaku Co., Ltd. | Piperidine derivative |
| US5276120A (en) * | 1991-05-30 | 1994-01-04 | The Scripps Research Institute | Process for forming omega-deuxy-azasugars |
| FI955286A7 (fi) | 1993-05-05 | 1996-01-03 | Roche Diagnostics Gmbh | Brevibacterium Sterolicumista peräisin oleva kolesterolioksidaasi |
| US6291657B1 (en) | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
| US5798366A (en) * | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
| US5451679A (en) * | 1994-03-08 | 1995-09-19 | G. D. Searle & Co. | 2-chloro and 2-bromo derivatives of 1,5-iminosugars |
| JP4564108B2 (ja) | 1996-07-15 | 2010-10-20 | ジェンザイム コーポレーション | デオキシノジリマイシン誘導体及び該誘導体のグルコシルセラミダーゼ阻害剤としての用途 |
| HUP0003362A3 (en) * | 1997-05-06 | 2001-04-28 | Novo Nordisk As | Piperidine derivatives and pharmaceutical compositions containing them |
| WO1999001555A1 (en) * | 1997-07-03 | 1999-01-14 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Genes for niemann-pick type c disease |
| AU753336B2 (en) | 1997-11-10 | 2002-10-17 | G.D. Searle & Co. | Use of alkylated iminosugars to treat multidrug resistance |
| US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| WO2000056334A1 (en) | 1999-03-19 | 2000-09-28 | The Trustees Of Boston College | Use of imino sugars for anti-tumor therapy |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| GB9909064D0 (en) | 1999-04-20 | 1999-06-16 | Oxford Glycosciences Uk Ltd | Therapies |
| AU6050600A (en) * | 1999-07-26 | 2001-02-13 | G.D. Searle & Co. | Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidaseenzyme for the manufacture of medicament for the treatment of glycolipid storag e diseases |
| US7256005B2 (en) * | 1999-08-10 | 2007-08-14 | The Chancellor, Masters And Scholars Of The University Of Oxford | Methods for identifying iminosugar derivatives that inhibit HCV p7 ion channel activity |
| AU1840101A (en) | 1999-08-10 | 2001-03-05 | Chancellor, Masters And Scholars Of The University Of Oxford, The | Long chain n-alkyl compounds and oxo-derivatives thereof |
| WO2002055489A2 (en) | 2000-12-27 | 2002-07-18 | Univ Columbia | Pim kinase-related methods |
| EP1524976B1 (en) * | 2002-03-13 | 2006-09-13 | Unither Pharmaceuticals, Inc. | A non-hormonal approach to male contraception |
| ES2393919T3 (es) | 2002-07-17 | 2013-01-02 | Actelion Pharmaceuticals Ltd. | Derivados de PIPERIDINETRIOL como inhibidores de GLUCOSILCERAMIDA SINTASA |
| JP4575156B2 (ja) * | 2002-07-17 | 2010-11-04 | アクテリオン ファーマシューティカルズ リミテッド | グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 |
| GB0313677D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| GB0313678D0 (en) | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
-
2003
- 2003-06-13 GB GBGB0313677.7A patent/GB0313677D0/en not_active Ceased
-
2004
- 2004-06-09 WO PCT/GB2004/002450 patent/WO2004111001A1/en not_active Ceased
- 2004-06-09 US US10/560,383 patent/US8022219B2/en not_active Expired - Fee Related
- 2004-06-09 ES ES04736421T patent/ES2391634T3/es not_active Expired - Lifetime
- 2004-06-09 JP JP2006516390A patent/JP4780784B2/ja not_active Expired - Fee Related
- 2004-06-09 CN CNB2004800162994A patent/CN100422150C/zh not_active Expired - Fee Related
- 2004-06-09 EP EP04736421A patent/EP1641755B1/en not_active Expired - Lifetime
- 2004-06-09 CA CA2528322A patent/CA2528322C/en not_active Expired - Fee Related
- 2004-06-09 AU AU2004247468A patent/AU2004247468B2/en not_active Ceased
- 2004-06-09 BR BRPI0411293A patent/BRPI0411293A8/pt not_active Application Discontinuation
-
2005
- 2005-12-13 IL IL172541A patent/IL172541A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2528322A1 (en) | 2004-12-23 |
| EP1641755B1 (en) | 2012-08-15 |
| GB0313677D0 (en) | 2003-07-16 |
| IL172541A (en) | 2011-07-31 |
| WO2004111001A1 (en) | 2004-12-23 |
| BRPI0411293A (pt) | 2006-08-29 |
| EP1641755A1 (en) | 2006-04-05 |
| ES2391634T3 (es) | 2012-11-28 |
| JP4780784B2 (ja) | 2011-09-28 |
| BRPI0411293A8 (pt) | 2017-12-26 |
| CN100422150C (zh) | 2008-10-01 |
| CN1805934A (zh) | 2006-07-19 |
| JP2006527252A (ja) | 2006-11-30 |
| AU2004247468B2 (en) | 2009-11-19 |
| US8022219B2 (en) | 2011-09-20 |
| US20070259918A1 (en) | 2007-11-08 |
| IL172541A0 (en) | 2006-04-10 |
| AU2004247468A1 (en) | 2004-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200831 |