CA2525091A1 - Water-soluble shps as novel alkylating agents - Google Patents
Water-soluble shps as novel alkylating agents Download PDFInfo
- Publication number
- CA2525091A1 CA2525091A1 CA002525091A CA2525091A CA2525091A1 CA 2525091 A1 CA2525091 A1 CA 2525091A1 CA 002525091 A CA002525091 A CA 002525091A CA 2525091 A CA2525091 A CA 2525091A CA 2525091 A1 CA2525091 A1 CA 2525091A1
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- CA
- Canada
- Prior art keywords
- compound according
- pharmaceutically acceptable
- patient
- acceptable salt
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
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Landscapes
- Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/461,282 | 2003-06-13 | ||
| US10/461,282 US6855695B2 (en) | 2003-06-13 | 2003-06-13 | Water-soluble SHPs as novel alkylating agents |
| PCT/US2004/015547 WO2005004897A1 (en) | 2003-06-13 | 2004-05-18 | Water-soluble shps as novel alkylating agents |
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| CA2525091A1 true CA2525091A1 (en) | 2005-01-20 |
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| CA002525091A Abandoned CA2525091A1 (en) | 2003-06-13 | 2004-05-18 | Water-soluble shps as novel alkylating agents |
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| Country | Link |
|---|---|
| US (2) | US6855695B2 (ja) |
| EP (1) | EP1644025A4 (ja) |
| JP (1) | JP2007516228A (ja) |
| CN (1) | CN100427139C (ja) |
| CA (1) | CA2525091A1 (ja) |
| HK (1) | HK1089368A1 (ja) |
| WO (1) | WO2005004897A1 (ja) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| ZA200507752B (en) * | 2003-03-28 | 2007-01-31 | Threshold Pharmaceuticals Inc | Compositions and methods for treating cancer |
| US7605137B2 (en) * | 2004-03-26 | 2009-10-20 | Vion Pharmaceuticals, Inc. | Combination therapy comprising cloretazine |
| WO2006034266A2 (en) * | 2004-09-21 | 2006-03-30 | Vion Pharmaceuticals, Inc. | Sulfonyl hydrazines as hypoxia-selective antineoplastic agents |
| PL1896040T3 (pl) | 2005-06-29 | 2012-12-31 | Threshold Pharmaceuticals Inc | Proleki alkilatora fosforoamidowego |
| DK1969031T3 (da) * | 2005-12-05 | 2009-09-14 | Nitto Denko Corp | Polyglutamat-aminosyre-konjugater og fremgangsmåder |
| WO2008083101A1 (en) * | 2006-12-26 | 2008-07-10 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs for the treatment of cancer |
| US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
| US20080253969A1 (en) * | 2007-04-10 | 2008-10-16 | Nitto Denko Corporation | Multi-functional polyglutamate drug carriers |
| PT2155255E (pt) | 2007-05-09 | 2013-10-15 | Nitto Denko Corp | Composições que incluem um composto hidrofóbico e um conjugado de poliaminoácido |
| EP2155254B1 (en) * | 2007-05-09 | 2012-11-28 | Nitto Denko Corporation | Polymers conjugated with platinum drugs |
| US20090118031A1 (en) * | 2007-11-01 | 2009-05-07 | Qualizza Gregory K | Shaft Structure with Configurable Bending Profile |
| RU2010137032A (ru) * | 2008-03-06 | 2012-04-20 | Нитто Денко Корпорейшн (Jp) | Конъюгаты паклитаксела с полимером и способы лечения рака |
| CN113121594A (zh) * | 2019-01-09 | 2021-07-16 | 西北工业大学 | 一种磷酰氧基苯甲醛肟类或磷酰氧基苯甲酮肟类化合物及其制备方法 |
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| US4175200A (en) | 1975-04-11 | 1979-11-20 | Uniroyal, Inc. | N,N-Disubstituted sulfonyl hydrazines |
| US4385055A (en) | 1979-01-04 | 1983-05-24 | The United States Of America As Represented By The Secretary Of The Army | 2-Acetyl-and 2-propionylpyridine thiosemicarbazones as antimalarials |
| US4447427A (en) | 1979-01-04 | 1984-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method for treating bacterial infections with 2-acetyl- and 2-propionylpyridine thiosemicarbazones |
| US4684747A (en) | 1984-12-20 | 1987-08-04 | Yale University | N,N'-bis(sulfonyl)hydrazines having antineoplastic activity |
| US4849563A (en) * | 1986-01-21 | 1989-07-18 | Yale University | Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity |
| US4696938A (en) | 1986-04-25 | 1987-09-29 | Rohm And Haas Company | Insecticidal 6-aryl-pyridine thiosemicarbazones |
| US5214068A (en) | 1989-09-06 | 1993-05-25 | Yale University | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents |
| US5101072A (en) | 1989-09-06 | 1992-03-31 | Yale University | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents |
| US5256820A (en) | 1991-11-08 | 1993-10-26 | Yale University | 1-alkyl-2-acyl-1,2-disulfonylhydrazines |
| US5637619A (en) * | 1995-07-05 | 1997-06-10 | Yale University | Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines |
| US5767134A (en) | 1997-05-15 | 1998-06-16 | Vion Pharmaceuticals, Inc. | Prodrug forms of ribonucleotide reductase inhibitors 3-AP and 3-AMP |
| US6040338A (en) * | 1997-11-03 | 2000-03-21 | Yale University | N,n-bis(sulfonyl)hydrazines useful as antineoplastic agents |
| US6139739A (en) * | 1998-10-08 | 2000-10-31 | Cuno Incorporated | Composite filter element |
| FR2812633A1 (fr) * | 2000-08-04 | 2002-02-08 | Aventis Cropscience Sa | Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides |
| CN1224388C (zh) | 2000-10-13 | 2005-10-26 | 维奥恩药品公司 | Ap/amp的改良前药形式 |
-
2003
- 2003-06-13 US US10/461,282 patent/US6855695B2/en not_active Expired - Lifetime
-
2004
- 2004-05-18 CA CA002525091A patent/CA2525091A1/en not_active Abandoned
- 2004-05-18 CN CNB2004800164701A patent/CN100427139C/zh not_active Expired - Fee Related
- 2004-05-18 EP EP04776031A patent/EP1644025A4/en not_active Withdrawn
- 2004-05-18 WO PCT/US2004/015547 patent/WO2005004897A1/en active Application Filing
- 2004-05-18 JP JP2006533183A patent/JP2007516228A/ja active Pending
- 2004-09-27 US US10/950,890 patent/US20050043244A1/en not_active Abandoned
-
2006
- 2006-09-04 HK HK06109806A patent/HK1089368A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007516228A (ja) | 2007-06-21 |
| US20050043244A1 (en) | 2005-02-24 |
| HK1089368A1 (en) | 2006-12-01 |
| EP1644025A4 (en) | 2006-11-15 |
| EP1644025A1 (en) | 2006-04-12 |
| CN100427139C (zh) | 2008-10-22 |
| CN1805752A (zh) | 2006-07-19 |
| US20040254103A1 (en) | 2004-12-16 |
| WO2005004897A1 (en) | 2005-01-20 |
| US6855695B2 (en) | 2005-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |