CA2524870A1 - Pharmaceutical combination comprising modafinil and another drug - Google Patents
Pharmaceutical combination comprising modafinil and another drug Download PDFInfo
- Publication number
- CA2524870A1 CA2524870A1 CA002524870A CA2524870A CA2524870A1 CA 2524870 A1 CA2524870 A1 CA 2524870A1 CA 002524870 A CA002524870 A CA 002524870A CA 2524870 A CA2524870 A CA 2524870A CA 2524870 A1 CA2524870 A1 CA 2524870A1
- Authority
- CA
- Canada
- Prior art keywords
- drug
- analeptic
- modafinil
- composition
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000003814 drug Substances 0.000 title claims abstract description 193
- 229940079593 drug Drugs 0.000 title claims abstract description 190
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 title claims abstract description 93
- 229960001165 modafinil Drugs 0.000 title claims abstract description 90
- 238000000034 method Methods 0.000 claims abstract description 75
- 239000000203 mixture Substances 0.000 claims abstract description 53
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 18
- 239000002269 analeptic agent Substances 0.000 claims description 128
- 230000003555 analeptic effect Effects 0.000 claims description 117
- 238000002651 drug therapy Methods 0.000 claims description 34
- 230000000694 effects Effects 0.000 claims description 26
- -1 cisplatinum Chemical compound 0.000 claims description 22
- 241001465754 Metazoa Species 0.000 claims description 21
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 20
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 20
- 208000024891 symptom Diseases 0.000 claims description 20
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- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 10
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47130203P | 2003-05-16 | 2003-05-16 | |
| US60/471,302 | 2003-05-16 | ||
| US10/845,836 | 2004-05-14 | ||
| US10/845,836 US20040229943A1 (en) | 2003-05-16 | 2004-05-14 | Analeptic and drug combinations |
| PCT/US2004/015408 WO2004103359A1 (en) | 2003-05-16 | 2004-05-17 | Pharmaceutical combination comprising modafinil and another drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2524870A1 true CA2524870A1 (en) | 2004-12-02 |
Family
ID=33424098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002524870A Abandoned CA2524870A1 (en) | 2003-05-16 | 2004-05-17 | Pharmaceutical combination comprising modafinil and another drug |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20040229943A1 (enExample) |
| EP (1) | EP1635807A1 (enExample) |
| JP (1) | JP2007506801A (enExample) |
| KR (1) | KR20060015727A (enExample) |
| AU (1) | AU2004241110A1 (enExample) |
| BR (1) | BRPI0411176A (enExample) |
| CA (1) | CA2524870A1 (enExample) |
| EA (1) | EA200501821A1 (enExample) |
| IS (1) | IS8099A (enExample) |
| MX (1) | MXPA05012358A (enExample) |
| MY (1) | MY135829A (enExample) |
| NO (1) | NO20055173L (enExample) |
| TW (1) | TW200509896A (enExample) |
| WO (1) | WO2004103359A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20030131B1 (en) * | 2000-07-27 | 2011-03-31 | Teva Pharmaceutical Industries Ltd. | Crystalline and pure modafinil, and process of preparing the same |
| US20070053976A1 (en) * | 2002-05-17 | 2007-03-08 | Eisai R & D Management Co., Ltd. | Novel combination of drugs as antidepressant |
| US6992219B2 (en) * | 2002-08-09 | 2006-01-31 | Cephalon France | Modafinil polymorphic forms |
| AR045423A1 (es) * | 2003-05-13 | 2005-10-26 | Cephalon Inc | Combinaciones de analiticos y antidepresivos |
| AR045314A1 (es) * | 2003-05-13 | 2005-10-26 | Cephalon Inc | Composiciones farmaceuticas de analepticos y antidepresivos |
| US20040242698A1 (en) * | 2003-05-13 | 2004-12-02 | Cephalon Inc. | Analeptic and antidepressant combinations |
| US7368591B2 (en) | 2003-09-19 | 2008-05-06 | Cephalon France | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
| WO2005099822A2 (en) * | 2004-04-13 | 2005-10-27 | Cephalon, Inc. | Reduction of drug / drug interactions with modafinil |
| EP1996291B1 (en) * | 2006-03-23 | 2010-11-17 | Yissum Research Development Company, of The Hebrew University of Jerusalem | Use of digitalis-like compounds in the treatment of affective disorders |
| DE102006015734A1 (de) * | 2006-04-04 | 2007-10-11 | Hermann, Holger Lars, Dr. | Kombinationspräparate aus Modafinil, Ritalin und Topiramat und deren Derivaten zur Behandlung von Kokainabhängigkeit und/oder Impulskontrollstörung |
| RU2435570C2 (ru) * | 2006-12-01 | 2011-12-10 | Нитто Денко Корпорейшн | Композиция для чрескожного всасывания |
| US20080131490A1 (en) * | 2006-12-01 | 2008-06-05 | Akinori Hanatani | Stabilized donepezil-containing patch preparation |
| WO2009145177A1 (ja) * | 2008-05-30 | 2009-12-03 | 日東電工株式会社 | ドネペジル含有貼付製剤およびその包装体 |
| CA2725484A1 (en) * | 2008-05-30 | 2009-12-03 | Eisai R&D Management Co., Ltd. | Percutaneously absorbable preparation |
| US20110224196A1 (en) * | 2010-01-07 | 2011-09-15 | Vivus, Inc. | Treatment of obstructive sleep apnea syndrome with a combination of a carbonic anhydrase inhibitor and an additional active agent |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696153A (en) * | 1994-05-16 | 1997-12-09 | Napro Biotherapeutics, Inc. | Therapeutic regimen for treating patients |
| FR2771004B1 (fr) * | 1997-11-19 | 2000-02-18 | Inst Curie | Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse |
| WO2001013921A1 (en) * | 1999-08-23 | 2001-03-01 | Ockert David M | Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms |
| US20010034373A1 (en) * | 2000-02-09 | 2001-10-25 | Matthew Miller | Low dose modafinil for enhancement of cognitive function |
| US6417184B1 (en) * | 2000-09-19 | 2002-07-09 | David M. Ockert | Triple drug therapy for the treatment and prevention of acute or chronic pain |
| US20030036555A1 (en) * | 2001-08-03 | 2003-02-20 | Boehringer Ingelheim Pharma Kg | Pramipexole for the treatment of ADHD |
| US20040229941A1 (en) * | 2003-05-13 | 2004-11-18 | Cephalon, Inc. | Analeptic and antidepressant combinations |
| AR045423A1 (es) * | 2003-05-13 | 2005-10-26 | Cephalon Inc | Combinaciones de analiticos y antidepresivos |
| AR045314A1 (es) * | 2003-05-13 | 2005-10-26 | Cephalon Inc | Composiciones farmaceuticas de analepticos y antidepresivos |
| US20040242698A1 (en) * | 2003-05-13 | 2004-12-02 | Cephalon Inc. | Analeptic and antidepressant combinations |
-
2004
- 2004-05-14 US US10/845,836 patent/US20040229943A1/en not_active Abandoned
- 2004-05-17 MX MXPA05012358A patent/MXPA05012358A/es not_active Application Discontinuation
- 2004-05-17 WO PCT/US2004/015408 patent/WO2004103359A1/en not_active Ceased
- 2004-05-17 EA EA200501821A patent/EA200501821A1/ru unknown
- 2004-05-17 EP EP04752424A patent/EP1635807A1/en not_active Withdrawn
- 2004-05-17 KR KR1020057021727A patent/KR20060015727A/ko not_active Withdrawn
- 2004-05-17 BR BRPI0411176-1A patent/BRPI0411176A/pt not_active IP Right Cessation
- 2004-05-17 CA CA002524870A patent/CA2524870A1/en not_active Abandoned
- 2004-05-17 AU AU2004241110A patent/AU2004241110A1/en not_active Abandoned
- 2004-05-17 MY MYPI20041851A patent/MY135829A/en unknown
- 2004-05-17 TW TW093113832A patent/TW200509896A/zh unknown
- 2004-05-17 JP JP2006533141A patent/JP2007506801A/ja not_active Withdrawn
-
2005
- 2005-10-27 IS IS8099A patent/IS8099A/is unknown
- 2005-11-03 NO NO20055173A patent/NO20055173L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA200501821A1 (ru) | 2006-06-30 |
| JP2007506801A (ja) | 2007-03-22 |
| TW200509896A (en) | 2005-03-16 |
| KR20060015727A (ko) | 2006-02-20 |
| MY135829A (en) | 2008-07-31 |
| MXPA05012358A (es) | 2006-02-02 |
| BRPI0411176A (pt) | 2006-07-18 |
| WO2004103359A1 (en) | 2004-12-02 |
| AU2004241110A1 (en) | 2004-12-02 |
| EP1635807A1 (en) | 2006-03-22 |
| NO20055173L (no) | 2005-12-12 |
| NO20055173D0 (no) | 2005-11-03 |
| IS8099A (is) | 2005-10-27 |
| US20040229943A1 (en) | 2004-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |