CA2521891C - Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) - Google Patents
Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) Download PDFInfo
- Publication number
- CA2521891C CA2521891C CA002521891A CA2521891A CA2521891C CA 2521891 C CA2521891 C CA 2521891C CA 002521891 A CA002521891 A CA 002521891A CA 2521891 A CA2521891 A CA 2521891A CA 2521891 C CA2521891 C CA 2521891C
- Authority
- CA
- Canada
- Prior art keywords
- atorvastatin
- hydrate
- crystalline form
- broad
- following
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30204901P | 2001-06-29 | 2001-06-29 | |
US60/302,049 | 2001-06-29 | ||
CA002450111A CA2450111C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002450111A Division CA2450111C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2521891A1 CA2521891A1 (fr) | 2003-01-16 |
CA2521891C true CA2521891C (fr) | 2006-04-25 |
Family
ID=35452260
Family Applications (14)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002521993A Abandoned CA2521993A1 (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide¬r-(r*,r*)|-2-(4-fluorop henyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino) carbonyl|-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521933A Expired - Fee Related CA2521933C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521958A Expired - Fee Related CA2521958C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521953A Expired - Fee Related CA2521953C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521956A Expired - Fee Related CA2521956C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002522899A Expired - Fee Related CA2522899C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521908A Expired - Fee Related CA2521908C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521887A Expired - Fee Related CA2521887C (fr) | 2001-06-29 | 2002-05-21 | Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin) |
CA002521980A Expired - Fee Related CA2521980C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide[r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521776A Expired - Fee Related CA2521776C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521792A Expired - Fee Related CA2521792C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521833A Expired - Fee Related CA2521833C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521828A Expired - Fee Related CA2521828C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521891A Expired - Fee Related CA2521891C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
Family Applications Before (13)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002521993A Abandoned CA2521993A1 (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide¬r-(r*,r*)|-2-(4-fluorop henyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino) carbonyl|-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521933A Expired - Fee Related CA2521933C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521958A Expired - Fee Related CA2521958C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521953A Expired - Fee Related CA2521953C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521956A Expired - Fee Related CA2521956C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002522899A Expired - Fee Related CA2522899C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521908A Expired - Fee Related CA2521908C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521887A Expired - Fee Related CA2521887C (fr) | 2001-06-29 | 2002-05-21 | Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin) |
CA002521980A Expired - Fee Related CA2521980C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide[r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521776A Expired - Fee Related CA2521776C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521792A Expired - Fee Related CA2521792C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521833A Expired - Fee Related CA2521833C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
CA002521828A Expired - Fee Related CA2521828C (fr) | 2001-06-29 | 2002-05-21 | Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) |
Country Status (1)
Country | Link |
---|---|
CA (14) | CA2521993A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20100023059A (ko) | 2005-12-13 | 2010-03-03 | 테바 파마슈티컬 인더스트리즈 리미티드 | 아토바스타틴 헤미칼슘의 결정형 및 이의 제조 방법 |
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2002
- 2002-05-21 CA CA002521993A patent/CA2521993A1/fr not_active Abandoned
- 2002-05-21 CA CA002521933A patent/CA2521933C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521958A patent/CA2521958C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521953A patent/CA2521953C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521956A patent/CA2521956C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002522899A patent/CA2522899C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521908A patent/CA2521908C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521887A patent/CA2521887C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521980A patent/CA2521980C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521776A patent/CA2521776C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521792A patent/CA2521792C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521833A patent/CA2521833C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521828A patent/CA2521828C/fr not_active Expired - Fee Related
- 2002-05-21 CA CA002521891A patent/CA2521891C/fr not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2521792C (fr) | 2006-04-25 |
CA2521828A1 (fr) | 2003-01-16 |
CA2521833A1 (fr) | 2003-01-16 |
CA2521980C (fr) | 2006-08-29 |
CA2521833C (fr) | 2006-04-25 |
CA2521891A1 (fr) | 2003-01-16 |
CA2521908C (fr) | 2006-04-25 |
CA2521776A1 (fr) | 2003-01-16 |
CA2521776C (fr) | 2006-04-25 |
CA2522899C (fr) | 2006-04-25 |
CA2521933C (fr) | 2006-03-21 |
CA2521887C (fr) | 2006-04-25 |
CA2522899A1 (fr) | 2003-01-16 |
CA2521953A1 (fr) | 2003-01-16 |
CA2521887A1 (fr) | 2003-01-16 |
CA2521958A1 (fr) | 2003-01-16 |
CA2521993A1 (fr) | 2003-01-16 |
CA2521980A1 (fr) | 2003-01-16 |
CA2521933A1 (fr) | 2003-01-16 |
CA2521956A1 (fr) | 2003-01-16 |
CA2521958C (fr) | 2006-08-29 |
CA2521953C (fr) | 2006-03-14 |
CA2521956C (fr) | 2006-04-25 |
CA2521792A1 (fr) | 2003-01-16 |
CA2521908A1 (fr) | 2003-01-16 |
CA2521828C (fr) | 2006-04-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20190521 |