CA2521776A1 - Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) - Google Patents

Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) Download PDF

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Publication number
CA2521776A1
CA2521776A1 CA002521776A CA2521776A CA2521776A1 CA 2521776 A1 CA2521776 A1 CA 2521776A1 CA 002521776 A CA002521776 A CA 002521776A CA 2521776 A CA2521776 A CA 2521776A CA 2521776 A1 CA2521776 A1 CA 2521776A1
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CA
Canada
Prior art keywords
phenylamino
methylethyl
fluorophenyl
pyrrole
dihydroxy
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002521776A
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English (en)
Other versions
CA2521776C (fr
Inventor
Stephen Robert Byrn
David Andrew Coates
Karen Sue Gushurst
Henry Grant Ii Morrison
Aeri Park
Petinka Ivanova Vlahova
Zheng Jane Li
Joseph Francis Krzyzaniak
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Warner Lambert Co LLC
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Individual
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Application filed by Individual filed Critical Individual
Priority claimed from CA002450111A external-priority patent/CA2450111C/fr
Publication of CA2521776A1 publication Critical patent/CA2521776A1/fr
Application granted granted Critical
Publication of CA2521776C publication Critical patent/CA2521776C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CA002521776A 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine) Expired - Fee Related CA2521776C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30204901P 2001-06-29 2001-06-29
US60/302,049 2001-06-29
CA002450111A CA2450111C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002450111A Division CA2450111C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)

Publications (2)

Publication Number Publication Date
CA2521776A1 true CA2521776A1 (fr) 2003-01-16
CA2521776C CA2521776C (fr) 2006-04-25

Family

ID=35452260

Family Applications (14)

Application Number Title Priority Date Filing Date
CA002521891A Expired - Fee Related CA2521891C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002522899A Expired - Fee Related CA2522899C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521953A Expired - Fee Related CA2521953C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521908A Expired - Fee Related CA2521908C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521958A Expired - Fee Related CA2521958C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521792A Expired - Fee Related CA2521792C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521933A Expired - Fee Related CA2521933C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521993A Abandoned CA2521993A1 (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide¬r-(r*,r*)|-2-(4-fluorop henyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino) carbonyl|-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521980A Expired - Fee Related CA2521980C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide[r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521828A Expired - Fee Related CA2521828C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521776A Expired - Fee Related CA2521776C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521956A Expired - Fee Related CA2521956C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521833A Expired - Fee Related CA2521833C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521887A Expired - Fee Related CA2521887C (fr) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Family Applications Before (10)

Application Number Title Priority Date Filing Date
CA002521891A Expired - Fee Related CA2521891C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002522899A Expired - Fee Related CA2522899C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521953A Expired - Fee Related CA2521953C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521908A Expired - Fee Related CA2521908C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521958A Expired - Fee Related CA2521958C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521792A Expired - Fee Related CA2521792C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521933A Expired - Fee Related CA2521933C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521993A Abandoned CA2521993A1 (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide¬r-(r*,r*)|-2-(4-fluorop henyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-¬(phenylamino) carbonyl|-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521980A Expired - Fee Related CA2521980C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide[r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521828A Expired - Fee Related CA2521828C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA002521956A Expired - Fee Related CA2521956C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521833A Expired - Fee Related CA2521833C (fr) 2001-06-29 2002-05-21 Formes cristallines de sel hemicalcique d'acide [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoique (2:1)(atorvastatine)
CA002521887A Expired - Fee Related CA2521887C (fr) 2001-06-29 2002-05-21 Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt(2:1)(atorvastatin)

Country Status (1)

Country Link
CA (14) CA2521891C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8080672B2 (en) 2005-12-13 2011-12-20 Teva Pharmaceutical Industries Ltd. Crystal form of atorvastatin hemi-calcium and processes for preparation thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8080672B2 (en) 2005-12-13 2011-12-20 Teva Pharmaceutical Industries Ltd. Crystal form of atorvastatin hemi-calcium and processes for preparation thereof

Also Published As

Publication number Publication date
CA2521833A1 (fr) 2003-01-16
CA2521887A1 (fr) 2003-01-16
CA2521980A1 (fr) 2003-01-16
CA2521828A1 (fr) 2003-01-16
CA2521993A1 (fr) 2003-01-16
CA2521956C (fr) 2006-04-25
CA2521953C (fr) 2006-03-14
CA2521958C (fr) 2006-08-29
CA2521887C (fr) 2006-04-25
CA2521953A1 (fr) 2003-01-16
CA2521908A1 (fr) 2003-01-16
CA2522899A1 (fr) 2003-01-16
CA2521891C (fr) 2006-04-25
CA2521792A1 (fr) 2003-01-16
CA2521908C (fr) 2006-04-25
CA2521956A1 (fr) 2003-01-16
CA2522899C (fr) 2006-04-25
CA2521776C (fr) 2006-04-25
CA2521980C (fr) 2006-08-29
CA2521933C (fr) 2006-03-21
CA2521828C (fr) 2006-04-25
CA2521833C (fr) 2006-04-25
CA2521891A1 (fr) 2003-01-16
CA2521933A1 (fr) 2003-01-16
CA2521792C (fr) 2006-04-25
CA2521958A1 (fr) 2003-01-16

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