CA2518969A1 - Blood treatment device and method with selective solute extraction - Google Patents

Blood treatment device and method with selective solute extraction Download PDF

Info

Publication number
CA2518969A1
CA2518969A1 CA002518969A CA2518969A CA2518969A1 CA 2518969 A1 CA2518969 A1 CA 2518969A1 CA 002518969 A CA002518969 A CA 002518969A CA 2518969 A CA2518969 A CA 2518969A CA 2518969 A1 CA2518969 A1 CA 2518969A1
Authority
CA
Canada
Prior art keywords
exchanger
outlet
treatment unit
membrane
inlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002518969A
Other languages
French (fr)
Other versions
CA2518969C (en
Inventor
Jacques Chevallet
Guy Mercier
Hiram Rada
Mehran Monchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gambro Lundia AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2518969A1 publication Critical patent/CA2518969A1/en
Application granted granted Critical
Publication of CA2518969C publication Critical patent/CA2518969C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3431—Substitution fluid path upstream of the filter
    • A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424—Substitution fluid path
    • A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3441—Substitution rate control as a function of the ultrafiltration rate
    • A61M1/3451—Substitution rate control as a function of the ultrafiltration rate the difference in weight between both ultra-filtrate and substitution reservoir being used as control signal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455—Substitution fluids
    • A61M1/3468—Substitution fluids using treated filtrate as substitution fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3479—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by dialysing the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3482—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate by filtrating the filtrate using another cross-flow filter, e.g. a membrane filter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The object of the present invention is the filtration of blood in order to selectively separate and extract molecules of a given size via extracorporeal systems for separating substances. The invention thus concerns an extracorporeal blood treatment device including: one or more exchangers (1) comprising a first inlet (2) for the blood to be treated, a first fluid outlet (4) and a second fluid outlet (5), an inlet line (10) for the blood to be treated, connected to the first inlet (2) of the exchanger (1), a blood outlet line (or venous line) (11) coupled to the first outlet (4) of the exchanger (1), one or more treatment units (21) comprising at least a first fluid inlet (22) and at least a first fluid outlet (24), wherein the second outlet (5) of the exchanger (1) is in fluid communication with the first inlet (22) of the treatment unit (21), the invention being characterised in that the first outlet (24) of the treatment unit (21) is in fluid communication with the inlet line (10).

Claims (52)

1. A device for the extracorporeal treatment of blood comprising:
- at least one exchanger (1) having a semi-permeable membrane (6) dividing said exchanger into a first chamber (7) and a second chamber (8), at least one first inlet (2) for blood to be treated in fluid communication with the first chamber (7), a first fluid outlet (4) in fluid communication with the first chamber (7) and a second fluid outlet (5) in fluid communication with the second chamber (8), - an input line (10) for blood to be treated connected to the first inlet (2) of the exchanger (1), - a blood output line (11) connected to the first outlet (4) of the exchanger (1), - at least one treatment unit (21) comprising a semi-permeable membrane (26), dividing the treatment unit (21) into a first chamber (27) and a second chamber (28), at least one first fluid inlet (22) in fluid communication with the second chamber (28), and at least one first fluid outlet (24) in fluid communication with the first chamber (27) of the treatment unit (21), - the second outlet (5) of the exchanger (1) being in fluid communication with the first inlet (22) of the treatment unit (21), - the first outlet (24) of the treatment unit (21) being in fluid communication with the input line (10), characterized in that - the treatment unit (21) includes a second fluid outlet (25) in fluid communication with the second chamber (28), - the second outlet (25) of the treatment unit (21) is in fluid communication with a first waste liquid discharge line (30).
2. A device according to the preceding claim, wherein the blood input line (10) connected to the first inlet (2) of the exchanger (1), the blood output line (11) connected to the first outlet (4) of the exchanger and the first chamber (7) of the exchanger form part of an extracorporeal blood treatment circuit.
3. A device according to claim 1 or 2, wherein a first duct (12) is connected between the second outlet (5) of the exchanger (1) and the first inlet (22) of the treatment unit(21) to carry out the fluid communication.

page 16 of 21
4. A device according to any of the preceding claims, wherein a second duct (40) is connected between the first outlet (24) of the treatment unit (21) and the first inlet (2) of exchanger (1) to carry out the fluid communication.
5. A device according to any of the preceding claims, wherein the exchanger (1) includes a second inlet (3) in fluid communication with the second chamber (8) and in fluid communication with a first source of dialysis liquid (9), the blood and the dialysis liquid circulating in opposite directions in each of the two chambers.
6. A device according to one of claims 1 to 5, characterized in that the first waste liquid discharge line (30) connects the second outlet (25) of the treatment unit (21) to a drain.
7. A device according to one of claims 1 to 5, characterized in that the first waste liquid discharge line (30) connects the second outlet (25) of the treatment unit (21) to a first container of used liquid (31).
8. A device according to any of the preceding claims, characterized in that the molecular permeability of the membrane (6) of the exchanger (1) is greater than the molecular permeability of the membrane (26) of the treatment unit (21), at least above a certain molecular weight.
9. A device according to any of the preceding claims, characterized in that the membrane (6) of the exchanger (1) is a high-flow membrane and the membrane (26) of the treatment unit (21) is a low-flow membrane.
10. A device according to anyone of claims 8 to 9 characterized in that the ratio between the cut-off value of the first membrane (6) and the cut-off value of the second membrane (26) is lower or equal to 3.
11. A device according to anyone of claims 8 to 10 characterized in that the difference in the cut-off value between the first membrane and the second membrane lies between 20 000 dalton and 30 000 dalton
12. A device according to any of claims 8 to 11 characterized in that the cut-off value of the first membrane is less than or equal to 40 000 dalton.

page 17
13. A device according to any of claims 8 to 12 characterized in that the cut-off value of the second membrane is less than or equal to 10 000 dalton.
14. A device according to any of claims 8 to 13 characterized in that the cut-off value of the first membrane is approximately 40 000 dalton.
15. A device according to any of claims 8 to 14 characterized in that the cut-off value of the second membrane is approximately 10 000 dalton.
16. A device according to any of the preceding claims, characterized in that a post-dilution line (50) is connected to the output line (11) and is connected to a first source of sterile liquid (51).
17. A device according to any of the preceding claims, characterized in that a pre-dilution line (60) is in fluid communication with the input line (10) and connected to a second source of sterile liquid (61).
18. A device according to one of claims 1 to 17 characterized in that the pre-dilution line (60) is connected directly to said duct (40).
19. A device according to one of claims 1 to 17 characterized in that the pre-dilution line (50) is connected directly to the input line (10).
20. A device according to any of claims 16 to 10 characterized in that at least one source of sterile liquid (51, 61) is a bag of sterile liquid.
21. A device according to any of claims 16 to 20 characterized in that at least one source of sterile liquid (51, 61) is obtained by an on-line preparation of sterile liquid using water taken from a mains supply.
22. A device according to any of claims 1 to 10 or 16 to 21, characterized in that the exchanger is a plasma filter.

page 18
23. A device according to claim 22 characterized in that the plasma filter has a cut-off value between one million and five million dalton.
24. A device according to claim 22 or 23 characterized in that the treatment unit has a semipermeable membrane (26) with cut-off value less than or equal to 250000 dalton.
25. A device according to one of claims 22 to 24 characterized in that the treatment unit (21) has a semipermeable membrane (26) with cut-off so that substantially all albumin molecules can go through said membrane.
26. A device according to one of claims 22 to 25 characterized in that includes means for reacting on at least certain molecules (70) placed on the first duct (12) and allowing the fluid communication between the second outlet (5) of the exchanger (1) and the first inlet (22) of the treatment unit (21).
27. A device according to claim 26 characterized in that the means for reacting on at least certain molecules is a reactor.
28. A device according to claim 26 characterized in that the means for reacting on at least certain molecules is an adsorption device.
29. A device according to claim 26 characterized in that the means for reacting on at least certain molecules is a radiation device.
30. A device according to any of the preceding claims, comprising at least:
- one auxiliary exchanger (81) with a membrane (86) separating it into a first chamber (87) in fluid communication with a first inlet (82) and a first outlet (84) and a second chamber (88) in fluid communication with at least one second outlet (85), the cut-off value of which is lower than the cut-off values of the membranes (6, 26) of the exchanger and of the treatment unit, - the first inlet (82) of said auxiliary exchanger (81) in fluid communication with the second outlet (24) of the treatment unit (21), and - one of the two outlets (84 or 85) of the auxiliary exchanger (81) in fluid communication with the first inlet (2) of the exchanger (1).

page 19
31. A device according to claim 30 characterized in that a second waste liquid discharge line (90) connects the other outlet (84 or 85) of the auxiliary exchanger (81) to a drain.
32. A device according to claim 31 characterized in that said drain is a second waste liquid container (91).
33. A device according to any of claims 30 to 32 characterized in that the auxiliary exchanger (81) has a second inlet (83) in fluid communication with the second chamber (88) of the auxiliary exchanger (81) and in fluid communication with a third source of dialysis liquid (89), - the first outlet (84) of the auxiliary exchanger (81) is in fluid communication with the first inlet (82) of the exchanger (1), - the second outlet (85) of the auxiliary exchanger (81) is in fluid communication with a drain (91) via a second waste liquid discharge line (90).
34. A device according to any of the preceding claims, characterized in that it includes first means to regulate liquid flow rate (101) placed on the input line (10) connected to the first inlet (2) of the exchanger (1).
35. A device according to claim 34 characterized in that the first means to regulate liquid flow rate (101) placed on the input line (10) is placed exactly between the first inlet (2) of the exchanger (1) and the connection point (110) connecting the input line to the duct.
36. A device according to claim 34 characterized in that the first means to regulate liquid flow rate (101) placed on the input line (10) is upstream of the connection point (110) connecting the input line (10) to the second duct (40) and the second means to regulate liquid flow rate (102) is placed on the second duct (40) connecting the first outlet (24) of the treatment unit (21) to the first inlet (2) of the exchanger (1).
37. A device according to any of claims 34 to 36 characterized in that it includes third means to regulate liquid flow rate (103) placed on the duct (12) connecting the second outlet (5) of the exchanger (1) to one of the two inlets (22, 23) of the treatment unit (21).
38. A device according to any of claims 34 to 37 characterized in that it includes fourth means to regulate liquid flow rate (104) placed on the post-dilution line (50).

page 20
39. A device according to any of claims 34 to 38 characterized in that it includes fifth means to regulate liquid flow rate (105) placed on the waste liquid discharge line (30) connecting the second outlet (25) of the treatment unit (21) to a drain (31).
40. A device according to any of claims 34 to 39 characterized in that it includes sixth means to regulate liquid flow rate (106) placed on the pre-dilution fine (60).
41. A device according to any of claims 38 to 40 characterized in that the first source (51) of sterile liquid for post-dilution is a bag of sterile liquid, and in that the first waste liquid container (31) connected to the discharge line from the treatment unit is a bag of waste liquid.
42. A device according to claim 41 characterized in that it includes a first balance (120) to weigh the bag of sterile liquid (51), and a second balance (121) to weigh the bag of waste liquid (31).
43. A device according to claim 41 characterized in that it includes a single balance (120-121) to weigh the bag of sterile liquid (51) together with the bag of waste liquid (31).
44. A device according to claim 42 or 43 characterized in that it includes a calculation and control unit (130) to receive signals emitted by at least one balance (120, 121) and to control the means to regulate active liquid flow rate (101, 102, 103, 104, or 105).
45. Method for the extracorporeal treatment of blood to be implemented on a device for the extracorporeal treatment of blood comprising:
- an exchanger (1) having a semi-permeable membrane (6) dividing said exchanger into a first chamber (7) connected to a first inlet (2) and to a first fluid outlet (4), and a second chamber (8) connected to a second fluid outlet (5), - a treatment unit (21) comprising a semi-permeable membrane (26), dividing the treatment unit (21) into a first chamber (27) connected to a first outlet (24) and into a second chamber (28) connected to a first inlet (22) and to a second outlet (25), a blood input line (10) connected to the first inlet (2) of the exchanger, - a blood output line (11) connected to the first outlet (4) of the exchanger (1), the method comprising the following steps:

page 21 - sending blood through the input line (10) connected to the first inlet of the exchanger (1), - sending the blood out from the first outlet of the exchanger (1) to the output line (11), - carrying out a first filtration of the blood in the exchanger (1), producing a first filtrate passing through the second outlet of the exchanger, - carrying out at least a second filtration of the first filtrate in the treatment unit (21), producing a second filtrate, - sending the second filtrate exiting the first outlet (24) of the treatment unit (21) to the input line (10) to effect a pre-dilution of the blood to be treated, - sending the non-filtered liquid through the second outlet (25) of the treatment unit (21) to the drain line (30).
46. Method according to claim 45 characterized in that the membrane (26) of the treatment unit filters molecules of molecular mass less than the molecular mass of the molecules filtered by the membrane (16) of the exchanger.
47. Method according to claim 45 or 46 including a step in which a sterile liquid is perfused in the blood output line (11) connected to the exchanger (1).
48, Method according to anyone of claims 45 to 47 including the step in which a sterile liquid is perfused in the blood input line (10) connected to the exchanger (1).
49. Method according to anyone of claims 45 to 48 characterized in that the exchanger membrane (16) has a cut-off value less than 40 000 dalton.
50. Method according to anyone of claims 45 to 49 characterized in that the treatment unit membrane (16) has cut-off value less than 10 000 dalton.
51. Method according to anyone of claims 45 to 48 characterized in that the exchanger membrane (16) has out-off value between one million and five million dalton.
52. Method according to anyone of claims 45 to 48 and 51 characterized in that the treatment unit membrane (16) has cut-off value less than 250 000 dalton.
CA2518969A 2003-03-17 2004-03-15 Blood treatment device and method with selective solute extraction Expired - Lifetime CA2518969C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0303257 2003-03-17
FR0303257A FR2852515B1 (en) 2003-03-17 2003-03-17 DEVICE AND METHOD FOR BLOOD TREATMENT WITH SELECTIVE EXTRACTION OF SOLUTES
PCT/IB2004/000896 WO2004082733A2 (en) 2003-03-17 2004-03-15 Blood treatment device and method with selective solute extraction

Publications (2)

Publication Number Publication Date
CA2518969A1 true CA2518969A1 (en) 2004-09-30
CA2518969C CA2518969C (en) 2011-05-24

Family

ID=32922232

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2518969A Expired - Lifetime CA2518969C (en) 2003-03-17 2004-03-15 Blood treatment device and method with selective solute extraction

Country Status (10)

Country Link
EP (2) EP2324870B1 (en)
JP (1) JP4571621B2 (en)
KR (1) KR101047970B1 (en)
CN (1) CN1761494B (en)
AT (1) ATE509649T1 (en)
CA (1) CA2518969C (en)
ES (1) ES2365136T3 (en)
FR (1) FR2852515B1 (en)
PL (1) PL1603609T3 (en)
WO (1) WO2004082733A2 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004054747A1 (en) * 2004-11-12 2006-05-24 Fresenius Medical Care Deutschland Gmbh Method and device for depleting at least one component of a fluid medium
SE532147C2 (en) 2005-02-16 2009-11-03 Triomed Ab Portable dialysis system
EP2002855B1 (en) * 2007-06-14 2012-07-11 RenApta B.V. Artificial kidney
US8298167B2 (en) * 2008-11-03 2012-10-30 B. Braun Avitum Ag Modular hemofiltration apparatus with interactive operator instructions and control system
EA022698B1 (en) * 2009-04-23 2016-02-29 Фрезениус Медикел Кеэ Дойчланд Гмбх Blood treatment cassette
DE102009026901A1 (en) 2009-06-10 2010-12-16 Fresenius Medical Care Deutschland Gmbh dialysis machine
AU2010292448C1 (en) * 2009-09-08 2015-08-13 Fresenius Medical Care Holdings, Inc. Peritoneal dialysis system
CN102107032B (en) * 2009-12-29 2014-08-27 重庆医科大学 External medicine feeding device applied in macromolecular drug of low-molecular substance in blood and application thereof
KR101227453B1 (en) * 2010-07-29 2013-01-29 서강대학교산학협력단 Artificial nephron device
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
ES2561461T3 (en) 2010-09-30 2016-02-26 Gambro Lundia Ab Apparatus for extracorporeal blood treatment
DE102011018601B4 (en) * 2011-04-21 2017-04-06 Fresenius Medical Care Deutschland Gmbh Apparatus for extracorporeal blood treatment and method for monitoring the fluid flow of an extracorporeal blood treatment device
DE102011108784A1 (en) * 2011-07-29 2013-01-31 Fresenius Medical Care Deutschland Gmbh Method and devices for checking at least one function of a medical functional device
PL2564885T3 (en) * 2011-08-30 2014-11-28 Gambro Lundia Ab Apparatus for extracorporeal treatment of blood and process of calculating set flow rates in a medical apparatus for delivery or collection of fluids
EP2644215B1 (en) * 2012-03-28 2014-12-17 Gambro Lundia AB Apparatus for extracorporeal treatment of blood
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US10203295B2 (en) 2016-04-14 2019-02-12 Lockheed Martin Corporation Methods for in situ monitoring and control of defect formation or healing
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
TW201504140A (en) 2013-03-12 2015-02-01 Lockheed Corp Method for forming perforated graphene with uniform aperture size
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
CA2938305A1 (en) 2014-01-31 2015-08-06 Lockheed Martin Corporation Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
SG11201606289RA (en) 2014-01-31 2016-08-30 Lockheed Corp Perforating two-dimensional materials using broad ion field
JP2017512129A (en) 2014-03-12 2017-05-18 ロッキード・マーチン・コーポレーション Separation membranes formed from perforated graphene
KR20170095804A (en) 2014-09-02 2017-08-23 록히드 마틴 코포레이션 Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same
JP2018528144A (en) 2015-08-05 2018-09-27 ロッキード・マーチン・コーポレーション Perforable sheet of graphene-based material
WO2017023377A1 (en) 2015-08-06 2017-02-09 Lockheed Martin Corporation Nanoparticle modification and perforation of graphene
WO2017180134A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
CA3020686A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Method for treating graphene sheets for large-scale transfer using free-float method
SG11201809016QA (en) 2016-04-14 2018-11-29 Lockheed Corp Selective interfacial mitigation of graphene defects
SG11201809015WA (en) 2016-04-14 2018-11-29 Lockheed Corp Two-dimensional membrane structures having flow passages
WO2017180135A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Membranes with tunable selectivity
TWI765069B (en) 2017-07-18 2022-05-21 德商費森尤斯醫療護理德國有限責任公司 Effluent bag, method of draining an effluent bag, discharge hose system, blood treatment apparatus
US20210338910A1 (en) * 2018-09-29 2021-11-04 Fresenius Medical Care Deutschland Gmbh Dialysis Device for Use with Interface Media, Dialysis Systems, Use of Dialysis Device, Method for Establishing Dialysis System, Method for Filling and/or Priming Dialysis System and Method for Removing Air from Dialysis System
WO2021203144A1 (en) * 2020-04-02 2021-10-07 Nuwellis, Inc. Multi-stage blood filtration
US11364330B2 (en) 2020-11-10 2022-06-21 Alfredo R. Zarate System and method for facilitating extracorporeal inactivation of pathogens of blood products
GB2624444A (en) * 2022-11-18 2024-05-22 Ipswich Medical A dialysis apparatus which ultra-filters blood and a related method

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52118895A (en) * 1976-03-29 1977-10-05 Asahi Chemical Ind Blood processor
GB1558370A (en) * 1975-09-26 1979-12-28 Asahi Chemical Ind Blood treating apparatus
DE3927633C1 (en) * 1989-08-22 1990-10-04 Fresenius Ag, 6380 Bad Homburg, De
DE4102693A1 (en) * 1991-01-30 1992-08-06 Schurek Hans Joachim Prof Dr M Blood dialysis machine - incorporate blood filter so that only filtrate is passed through dialyser
AU7498994A (en) * 1993-08-10 1995-02-28 Ao Forschungsinstitut Davos Treatment of tumors by selective protein depletion
AU2069695A (en) * 1995-03-13 1996-10-02 Ao Forschungsinstitut Davos An extracorporeal blood treatment apparatus and method for removal of free circulating infectious agents
EP0832656A1 (en) * 1996-09-30 1998-04-01 B. BRAUN CAREX S.p.A. Method and apparatus for controlling the fluid balance of patients subjected to single-needle blood treatments
US6193681B1 (en) * 1998-09-14 2001-02-27 American Immuno Tech, Llc. Septicemia prevention and treatment system
DE19854338B4 (en) * 1998-11-25 2005-11-17 Ulrich Dr.med. Saueressig Method and device for renal replacement therapy
FR2800618B1 (en) * 1999-11-08 2002-02-22 Bert Christophe HEMO-FILTRATION APPARATUS FOR INDEPENDENTLY CONTROLLING THE CONCENTRATION OF AT LEAST TWO IONIC SUBSTANCES IN THE INTERIOR OF A PATIENT
US6842522B1 (en) * 2000-06-01 2005-01-11 Macrovision Corporation Secure digital video disk and player

Also Published As

Publication number Publication date
CN1761494A (en) 2006-04-19
CN1761494B (en) 2010-04-07
PL1603609T3 (en) 2011-12-30
EP2324870A1 (en) 2011-05-25
KR20050113232A (en) 2005-12-01
WO2004082733A8 (en) 2005-04-07
EP1603609B1 (en) 2011-05-18
JP4571621B2 (en) 2010-10-27
WO2004082733A9 (en) 2005-02-17
EP2324870B1 (en) 2016-06-01
CA2518969C (en) 2011-05-24
JP2006520635A (en) 2006-09-14
WO2004082733A2 (en) 2004-09-30
FR2852515B1 (en) 2005-11-18
ES2365136T3 (en) 2011-09-23
ATE509649T1 (en) 2011-06-15
EP1603609A2 (en) 2005-12-14
KR101047970B1 (en) 2011-07-13
FR2852515A1 (en) 2004-09-24
WO2004082733A3 (en) 2004-11-04
AU2004222460A1 (en) 2004-09-30

Similar Documents

Publication Publication Date Title
CA2518969A1 (en) Blood treatment device and method with selective solute extraction
US7291269B2 (en) Apparatus and process for extracorporeal treatment of blood with selective extraction of solutes
JP4098624B2 (en) Multistage hemodiafiltration / blood filtration method and apparatus
EP2101841B1 (en) Blood treatment apparatus
JP2004512873A (en) Two-stage diafiltration method and apparatus
US4783273A (en) Method and apparatus for supplying concentrate for use in medical treatments
CA2668749C (en) An apparatus for extracorporeal blood treatment
ATE352332T1 (en) METHOD AND DEVICE FOR PERFORMING CONTROLLED ULTRAFILTRATION OF DIALYSATE DURING HEMODIALYSIS
EP2800592A1 (en) Multi-staged filtration system for blood fluid removal
CA2372307A1 (en) Device and method for controlling infusion of a liquid in an extracorporeal blood circuit
EP1137482B2 (en) Non-isosmotic diafiltration system
JPS6247366A (en) Blood dialyzing and filtering apparatus
TWI574706B (en) Dialysis device
CN203619966U (en) Blood ascites purifying device for hemodiafiltration joint ascites ultrafiltration and reinfusion
CN108697987A (en) System and method for filtering fluid
CN111068134A (en) Blood purifier without dialysate
DE60300202D1 (en) Device for controlling and regulating the flow of dialysate in a hemodiafiltration method
CN109641096B (en) Blood treatment device and method for operating a blood treatment device
CN2785558Y (en) Mixed type artificial and biological liver system
RU2180859C1 (en) Artificial kidney apparatus
JPH06134032A (en) Artificial dialyzing method having backwashing support and device therefor

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20240315