CA2495698A1 - Imidazol-1-ylmethyl pyridazine derivatives - Google Patents
Imidazol-1-ylmethyl pyridazine derivatives Download PDFInfo
- Publication number
- CA2495698A1 CA2495698A1 CA002495698A CA2495698A CA2495698A1 CA 2495698 A1 CA2495698 A1 CA 2495698A1 CA 002495698 A CA002495698 A CA 002495698A CA 2495698 A CA2495698 A CA 2495698A CA 2495698 A1 CA2495698 A1 CA 2495698A1
- Authority
- CA
- Canada
- Prior art keywords
- imidazol
- ylmethyl
- pyridazine
- compound
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41666002P | 2002-10-07 | 2002-10-07 | |
| US60/416,660 | 2002-10-07 | ||
| PCT/IB2003/004382 WO2004031174A1 (en) | 2002-10-07 | 2003-10-06 | Imidazol-1-ylmethyl pyridazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2495698A1 true CA2495698A1 (en) | 2004-04-15 |
Family
ID=32069951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002495698A Abandoned CA2495698A1 (en) | 2002-10-07 | 2003-10-06 | Imidazol-1-ylmethyl pyridazine derivatives |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7122546B2 (enExample) |
| EP (1) | EP1549636A1 (enExample) |
| JP (1) | JP2006504714A (enExample) |
| CN (1) | CN100579579C (enExample) |
| AU (1) | AU2003267722A1 (enExample) |
| CA (1) | CA2495698A1 (enExample) |
| WO (1) | WO2004031174A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006508102A (ja) * | 2002-11-08 | 2006-03-09 | ニューロジェン・コーポレイション | Ｇａｂａａ受容体のリガンドとしての４−イミダゾール−１−イルメチル−ピリミジン誘導体 |
| CA2508731A1 (en) | 2003-02-19 | 2004-09-02 | Neurogen Corporation | Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds |
| US7271170B2 (en) * | 2003-07-25 | 2007-09-18 | Neurogen Corporation | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
| MXPA06014909A (es) * | 2004-06-18 | 2007-02-28 | Chiron Corp | Derivados de n-(1-(1-bencil -4-fenil-1h -imidazol -2-il)-2, 2-dimetilpropil) benzamida y compuestos relacionados como inhibidores de proteina de huso de cinesina (ksp) para el tratamiento del cancer. |
| KR20090097210A (ko) | 2007-01-05 | 2009-09-15 | 노파르티스 아게 | 키네신 방추체 단백질 (ｅｇ－５) 억제제로서의 이미다졸 유도체 |
| MX2009007661A (es) | 2007-01-19 | 2009-12-14 | Ardea Biosciences Inc | Inhibidores de mek. |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| SG10201704903YA (en) * | 2012-12-21 | 2017-07-28 | Celverum Inc | Non-replicating virus-derived particles and uses thereof |
| WO2018183656A1 (en) | 2017-03-30 | 2018-10-04 | Bristol-Myers Squibb Company | Crystal form of 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3) pyridazine-3-carboxamide |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6200959B1 (en) * | 1996-12-04 | 2001-03-13 | Powerject Vaccines Inc. | Genetic induction of anti-viral immune response and genetic vaccine for filovirus |
| AU6411199A (en) * | 1998-10-13 | 2000-05-01 | Chiron Corporation | Angiogenically effective unit dose of fgf and method of administering |
| US6552037B2 (en) * | 2000-06-30 | 2003-04-22 | Neurogen Corporation | 2-Substituted imidazo[1,2-A]pyridine derivatives |
| PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| WO2004041809A2 (en) * | 2002-05-08 | 2004-05-21 | Neurogen Corporation | Substituted imidazolylmethyl pyridine and pyrazine derivatives and their use as gabaa receptor ligands |
| US7005432B2 (en) * | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
| JP2006508102A (ja) | 2002-11-08 | 2006-03-09 | ニューロジェン・コーポレイション | Ｇａｂａａ受容体のリガンドとしての４−イミダゾール−１−イルメチル−ピリミジン誘導体 |
| US20060247245A1 (en) | 2003-05-05 | 2006-11-02 | Yuelian Xu | Substituted imidazolopyrazine and triazolopyrazine derivatives: gabaa receptor ligands |
-
2003
- 2003-10-01 CN CN200380104308A patent/CN100579579C/zh not_active Expired - Fee Related
- 2003-10-06 JP JP2004541111A patent/JP2006504714A/ja active Pending
- 2003-10-06 WO PCT/IB2003/004382 patent/WO2004031174A1/en not_active Ceased
- 2003-10-06 CA CA002495698A patent/CA2495698A1/en not_active Abandoned
- 2003-10-06 EP EP03748416A patent/EP1549636A1/en not_active Withdrawn
- 2003-10-06 AU AU2003267722A patent/AU2003267722A1/en not_active Abandoned
- 2003-10-07 US US10/680,351 patent/US7122546B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1717250A (zh) | 2006-01-04 |
| US7122546B2 (en) | 2006-10-17 |
| AU2003267722A8 (en) | 2004-04-23 |
| CN100579579C (zh) | 2010-01-13 |
| WO2004031174A1 (en) | 2004-04-15 |
| WO2004031174A8 (en) | 2005-04-21 |
| US20040077653A1 (en) | 2004-04-22 |
| JP2006504714A (ja) | 2006-02-09 |
| AU2003267722A1 (en) | 2004-04-23 |
| EP1549636A1 (en) | 2005-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20060247245A1 (en) | Substituted imidazolopyrazine and triazolopyrazine derivatives: gabaa receptor ligands | |
| CA2555263A1 (en) | Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands | |
| US20080139580A1 (en) | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands | |
| CA2495698A1 (en) | Imidazol-1-ylmethyl pyridazine derivatives | |
| US7351826B2 (en) | Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds | |
| EP1560822B1 (en) | 4-imidazol-1-ylmethyl-pyrimidine derivatives as ligands for gabaa receptors | |
| CA2441926A1 (en) | (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides | |
| US20080132510A1 (en) | Imidazolylmethyl and Pyrazolylmethyl Heteroaryl Derivatives | |
| US20080167324A1 (en) | Thiazolymethyl and Oxazolylmethyl Heteroaryl Derivatives | |
| CN100457756C (zh) | 咪唑-嘧啶类及三唑-嘧啶类:苯并二氮平受体配体 | |
| EP1880998A1 (en) | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands | |
| HK1089446B (en) | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |