CA2494607A1 - Human g protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure - Google Patents
Human g protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure Download PDFInfo
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- CA2494607A1 CA2494607A1 CA002494607A CA2494607A CA2494607A1 CA 2494607 A1 CA2494607 A1 CA 2494607A1 CA 002494607 A CA002494607 A CA 002494607A CA 2494607 A CA2494607 A CA 2494607A CA 2494607 A1 CA2494607 A1 CA 2494607A1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Vascular Medicine (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40077402P | 2002-08-01 | 2002-08-01 | |
| US60/400,774 | 2002-08-01 | ||
| PCT/US2003/023296 WO2004013285A2 (en) | 2002-08-01 | 2003-07-25 | Human g protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2494607A1 true CA2494607A1 (en) | 2004-02-12 |
Family
ID=31495875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002494607A Abandoned CA2494607A1 (en) | 2002-08-01 | 2003-07-25 | Human g protein-coupled receptor and modulators thereof for the treatment of ischemic heart disease and congestive heart failure |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7611832B2 (https=) |
| EP (1) | EP1543025A4 (https=) |
| JP (1) | JP2005534319A (https=) |
| CN (1) | CN100473662C (https=) |
| AU (1) | AU2003259237B2 (https=) |
| CA (1) | CA2494607A1 (https=) |
| TW (3) | TW200800009A (https=) |
| WO (1) | WO2004013285A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100473662C (zh) | 2002-08-01 | 2009-04-01 | 阿瑞那制药公司 | 治疗缺血性心脏病及充血性心衰竭的人类g蛋白偶联受体及其调节物 |
| AU2005301988A1 (en) * | 2004-11-08 | 2006-05-11 | University Of Rochester | Transgenic non-human animal models of ischemia-reperfusion injury and uses thereof |
| WO2015131099A1 (en) * | 2014-02-28 | 2015-09-03 | The General Hospital Corporation | Diagnosis of multiple myeloma and lymphoma |
| CA2945706C (en) * | 2014-04-25 | 2023-10-24 | Libramen Naturals Inc. | G-protein coupled receptor 22 transformed cell lines and uses therefor |
| CN110772636B (zh) * | 2017-08-21 | 2021-03-16 | 武汉大学 | Gpr31抑制剂在制备治疗心脏缺血再灌注损伤及相关疾病药物中的应用 |
| CN114642668B (zh) * | 2020-12-21 | 2024-04-05 | 忻佑康医药科技(南京)有限公司 | 拉坦前列素的药物新用途 |
| CN119351340B (zh) * | 2024-10-31 | 2025-07-08 | 中国食品药品检定研究院(国家药品监督管理局医疗器械标准管理中心、中国药品检验总所) | 一种测定rhTSH药物生物学活性的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE335818T1 (de) * | 1995-12-28 | 2006-09-15 | Takeda Pharmaceutical | Ligand polypeptide für hypophyse g-protein gekoppeltes rezeptor-protein, deren herstellung und anwendung |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| US5994097A (en) | 1997-08-28 | 1999-11-30 | Incyte Pharmaceuticals, Inc. | Polynucleotide encoding human G-protein coupled receptor |
| EP1297127A2 (en) * | 2000-05-03 | 2003-04-02 | AstraZeneca AB | Gpr22 modulators as appetite-control agents |
| WO2002006445A2 (en) | 2000-07-19 | 2002-01-24 | Deltagen, Inc. | Transgenic mice containing targeted gene disruptions |
| WO2002061432A2 (en) | 2001-02-01 | 2002-08-08 | Lifespan Biosciences, Inc. | Gpr22, a g protein-coupled receptor (gpcr) and compositions and methods related thereto |
| JP2005516605A (ja) | 2002-02-01 | 2005-06-09 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 心血管疾患を処置するための方法および組成物 |
| CN100473662C (zh) | 2002-08-01 | 2009-04-01 | 阿瑞那制药公司 | 治疗缺血性心脏病及充血性心衰竭的人类g蛋白偶联受体及其调节物 |
| CN101287832A (zh) | 2005-10-14 | 2008-10-15 | 艾尼纳制药公司 | Gpr22和其相关方法 |
-
2003
- 2003-07-25 CN CNB038234882A patent/CN100473662C/zh not_active Expired - Fee Related
- 2003-07-25 US US10/523,100 patent/US7611832B2/en not_active Expired - Fee Related
- 2003-07-25 EP EP03766914A patent/EP1543025A4/en not_active Withdrawn
- 2003-07-25 AU AU2003259237A patent/AU2003259237B2/en not_active Ceased
- 2003-07-25 CA CA002494607A patent/CA2494607A1/en not_active Abandoned
- 2003-07-25 WO PCT/US2003/023296 patent/WO2004013285A2/en not_active Ceased
- 2003-07-25 JP JP2004526159A patent/JP2005534319A/ja active Pending
- 2003-07-30 TW TW096125738A patent/TW200800009A/zh unknown
- 2003-07-30 TW TW096144624A patent/TW200815603A/zh unknown
- 2003-07-30 TW TW092120775A patent/TWI291555B/zh not_active IP Right Cessation
-
2006
- 2006-11-22 US US11/604,179 patent/US20070224127A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200410985A (en) | 2004-07-01 |
| EP1543025A2 (en) | 2005-06-22 |
| US20070224127A1 (en) | 2007-09-27 |
| US7611832B2 (en) | 2009-11-03 |
| EP1543025A4 (en) | 2006-03-15 |
| US20050238579A1 (en) | 2005-10-27 |
| TWI291555B (en) | 2007-12-21 |
| TW200815603A (en) | 2008-04-01 |
| CN100473662C (zh) | 2009-04-01 |
| AU2003259237A1 (en) | 2004-02-23 |
| AU2003259237B2 (en) | 2011-01-06 |
| WO2004013285A3 (en) | 2004-06-10 |
| WO2004013285A2 (en) | 2004-02-12 |
| TW200800009A (en) | 2008-01-01 |
| JP2005534319A (ja) | 2005-11-17 |
| CN1684975A (zh) | 2005-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |