CA2490509C - Improved method of reducing the effects of background noise in mass spectra - Google Patents
Improved method of reducing the effects of background noise in mass spectra Download PDFInfo
- Publication number
- CA2490509C CA2490509C CA2490509A CA2490509A CA2490509C CA 2490509 C CA2490509 C CA 2490509C CA 2490509 A CA2490509 A CA 2490509A CA 2490509 A CA2490509 A CA 2490509A CA 2490509 C CA2490509 C CA 2490509C
- Authority
- CA
- Canada
- Prior art keywords
- amu
- mass
- intensity
- spectral data
- regions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 51
- 238000001819 mass spectrum Methods 0.000 title claims description 111
- 230000000694 effects Effects 0.000 title claims description 15
- 230000003595 spectral effect Effects 0.000 claims abstract description 69
- 238000004949 mass spectrometry Methods 0.000 claims abstract description 4
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 7
- 230000001133 acceleration Effects 0.000 claims description 4
- 238000000451 chemical ionisation Methods 0.000 claims description 4
- 238000003795 desorption Methods 0.000 claims description 4
- 238000000688 desorption electrospray ionisation Methods 0.000 claims description 4
- 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims description 4
- 238000009616 inductively coupled plasma Methods 0.000 claims description 4
- 238000005040 ion trap Methods 0.000 claims description 4
- 238000001698 laser desorption ionisation Methods 0.000 claims description 4
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 3
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 3
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 3
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 claims description 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 238000010265 fast atom bombardment Methods 0.000 claims 2
- 230000000737 periodic effect Effects 0.000 abstract description 34
- 150000002500 ions Chemical class 0.000 description 44
- 239000000126 substance Substances 0.000 description 27
- 239000012491 analyte Substances 0.000 description 15
- 238000001914 filtration Methods 0.000 description 8
- 230000001747 exhibiting effect Effects 0.000 description 6
- 238000001228 spectrum Methods 0.000 description 6
- 229930195734 saturated hydrocarbon Natural products 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical class BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229910002804 graphite Inorganic materials 0.000 description 2
- 239000010439 graphite Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000003252 repetitive effect Effects 0.000 description 2
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000011410 subtraction method Methods 0.000 description 1
- 238000001196 time-of-flight mass spectrum Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0329554.0 | 2003-12-22 | ||
| GBGB0329554.0A GB0329554D0 (en) | 2003-12-22 | 2003-12-22 | Mass spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2490509A1 CA2490509A1 (en) | 2005-06-22 |
| CA2490509C true CA2490509C (en) | 2014-03-04 |
Family
ID=30776183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2490509A Expired - Fee Related CA2490509C (en) | 2003-12-22 | 2004-12-17 | Improved method of reducing the effects of background noise in mass spectra |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP4806182B2 (de) |
| CA (1) | CA2490509C (de) |
| DE (2) | DE202004019529U1 (de) |
| GB (2) | GB0329554D0 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638764B2 (en) | 2007-02-02 | 2009-12-29 | Mds Analytical Technologies | Systems and methods for reducing noise from mass spectra |
| GB0709312D0 (en) | 2007-05-15 | 2007-06-20 | Micromass Ltd | Mass spectrometer |
| JP2012517588A (ja) * | 2009-02-06 | 2012-08-02 | マイクロマス・ユー・ケイ・リミテツド | 質量分析方法 |
| GB201205805D0 (en) | 2012-03-30 | 2012-05-16 | Micromass Ltd | Mass spectrometer |
| JP7249980B2 (ja) * | 2020-10-26 | 2023-03-31 | 日本電子株式会社 | マススペクトル処理装置及び方法 |
| CN112630292A (zh) * | 2020-12-15 | 2021-04-09 | 天津中环领先材料技术有限公司 | 一种氧化膜硅基产品磷含量的测试方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9612091D0 (en) * | 1996-06-10 | 1996-08-14 | Hd Technologies Limited | Improvements in or relating to time-of-flight mass spectrometers |
| JP3741563B2 (ja) * | 1999-04-15 | 2006-02-01 | 日本電子株式会社 | 質量分析装置用データ収集システム |
| US6449584B1 (en) * | 1999-11-08 | 2002-09-10 | Université de Montréal | Measurement signal processing method |
| WO2002061661A2 (en) * | 2000-10-19 | 2002-08-08 | Target Discovery, Inc. | Methods for determining protein and peptide terminal sequences |
| US6787761B2 (en) * | 2000-11-27 | 2004-09-07 | Surromed, Inc. | Median filter for liquid chromatography-mass spectrometry data |
-
2003
- 2003-12-22 GB GBGB0329554.0A patent/GB0329554D0/en not_active Ceased
-
2004
- 2004-12-15 GB GB0427478A patent/GB2409568B/en active Active
- 2004-12-17 DE DE202004019529U patent/DE202004019529U1/de not_active Expired - Lifetime
- 2004-12-17 DE DE102004060888A patent/DE102004060888B4/de active Active
- 2004-12-17 CA CA2490509A patent/CA2490509C/en not_active Expired - Fee Related
- 2004-12-21 JP JP2004369495A patent/JP4806182B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE202004019529U1 (de) | 2005-05-04 |
| GB2409568A (en) | 2005-06-29 |
| DE102004060888B4 (de) | 2009-11-19 |
| JP2005201899A (ja) | 2005-07-28 |
| GB0427478D0 (en) | 2005-01-19 |
| GB2409568B (en) | 2006-11-29 |
| DE102004060888A1 (de) | 2005-08-04 |
| CA2490509A1 (en) | 2005-06-22 |
| GB0329554D0 (en) | 2004-01-28 |
| JP4806182B2 (ja) | 2011-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20210831 |
|
| MKLA | Lapsed |
Effective date: 20191217 |