CA2483875C - Derives de l'erythromycine 6,11 bicyclique - Google Patents

Derives de l'erythromycine 6,11 bicyclique Download PDF

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Publication number
CA2483875C
CA2483875C CA002483875A CA2483875A CA2483875C CA 2483875 C CA2483875 C CA 2483875C CA 002483875 A CA002483875 A CA 002483875A CA 2483875 A CA2483875 A CA 2483875A CA 2483875 C CA2483875 C CA 2483875C
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CA
Canada
Prior art keywords
compound
formula
taken together
attached
carbon atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002483875A
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English (en)
Other versions
CA2483875A1 (fr
Inventor
Yat Sun Or
Guoqiang Wang
Ly Tam Phan
Deqiang Niu
Yao-Ling Qiu
Nha Huu Vo
Jay Judson Farmer
Ying Hou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enanta Pharmaceuticals Inc
Original Assignee
Enanta Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Enanta Pharmaceuticals Inc filed Critical Enanta Pharmaceuticals Inc
Priority claimed from US10/436,622 external-priority patent/US7129221B2/en
Publication of CA2483875A1 publication Critical patent/CA2483875A1/fr
Application granted granted Critical
Publication of CA2483875C publication Critical patent/CA2483875C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention concerne des composés de formule (I), ou des sels, des esters ou des promédicaments pharmaceutiquement acceptables de ceux-ci qui présentent des propriétés antibactériennes. Par ailleurs, l'invention concerne des compositions pharmaceutiques contenant les composés précités, qui sont destinées à être administrées à un sujet ayant besoin d'un traitement antibiotique. De plus, l'invention concerne des méthodes de traitement d'une infection bactérienne chez un sujet, qui consistent à lui administrer une composition pharmaceutique renfermant les composés de l'invention. L'invention concerne enfin un procédé de préparation de ces composés.
CA002483875A 2002-05-13 2003-05-13 Derives de l'erythromycine 6,11 bicyclique Expired - Fee Related CA2483875C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14439602A 2002-05-13 2002-05-13
US10/144,396 2002-05-13
US10/436,622 US7129221B2 (en) 2002-05-13 2003-05-13 6,11-bicyclic erythromycin derivatives
US10/436,622 2003-05-13
PCT/US2003/014914 WO2003095466A1 (fr) 2002-05-13 2003-05-13 Derives de l'erythromycine 6,11 bicyclique

Publications (2)

Publication Number Publication Date
CA2483875A1 CA2483875A1 (fr) 2003-11-20
CA2483875C true CA2483875C (fr) 2008-09-23

Family

ID=29418515

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002483875A Expired - Fee Related CA2483875C (fr) 2002-05-13 2003-05-13 Derives de l'erythromycine 6,11 bicyclique

Country Status (3)

Country Link
AU (1) AU2003229037B8 (fr)
CA (1) CA2483875C (fr)
WO (1) WO2003095466A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135573B2 (en) 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US7910558B2 (en) 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
WO2005070918A1 (fr) * 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Procede de preparation de derives bicycliques 6-11 d'erythromycine
WO2005028493A1 (fr) * 2003-09-12 2005-03-31 Chiron Corporation Derives antimicrobiens
US7414030B2 (en) 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
CN1910171B (zh) * 2004-01-14 2011-09-28 伊南塔医药品股份有限公司 6-11双环红霉素衍生物的制备方法
WO2005080408A1 (fr) * 2004-01-23 2005-09-01 Enanta Pharmaceuticals, Inc. Composes macrocycliques pontes et procedes de preparation desdits composes
US7384921B2 (en) 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
JP2008522978A (ja) 2004-12-07 2008-07-03 エナンタ ファーマシューティカルズ インコーポレイテッド ３，６−ビシクロライド
US7229972B2 (en) 2004-12-07 2007-06-12 Enanta Pharmaceuticals, Inc. 3,6-Bicyclolides
US7312201B2 (en) 2004-12-13 2007-12-25 Enanta Pharmaceuticals, Inc. Tetracyclic bicyclolides
WO2006065721A2 (fr) 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. Bicyclolides de 11, 12-lactone
US7384922B2 (en) 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
JP2008540432A (ja) * 2005-05-04 2008-11-20 エナンタ ファーマシューティカルズ インコーポレイテッド ６−１１橋かけオキシムエリスロマイシン誘導体
US7589067B2 (en) 2005-10-12 2009-09-15 Enanta Pharmaceuticals, Inc. 6, 11-bridged tricyclic macrolides
US7407942B2 (en) 2006-03-29 2008-08-05 Emata Pharmaceuticals, Inc 3,6-bridged 9,12-oxolides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046171A (en) * 1997-10-29 2000-04-04 Abbott Laboratories 6,11-bridged erythromycin derivatives
AR015986A1 (es) * 1997-10-29 2001-05-30 Abbott Lab Derivados de eritromicina puenteados en 6,11, composiciones farmaceuticas que los contienen, su uso para la manufactura de un medicamento y procedimientospara su preparacion

Also Published As

Publication number Publication date
AU2003229037B8 (en) 2009-07-02
CA2483875A1 (fr) 2003-11-20
AU2003229037A1 (en) 2003-11-11
AU2003229037B2 (en) 2007-01-18
WO2003095466A1 (fr) 2003-11-20

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Effective date: 20190513