CA2477094A1 - Vaccin a base de ricin et ses procedes de fabrication et d'utilisation - Google Patents

Vaccin a base de ricin et ses procedes de fabrication et d'utilisation Download PDF

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Publication number
CA2477094A1
CA2477094A1 CA002477094A CA2477094A CA2477094A1 CA 2477094 A1 CA2477094 A1 CA 2477094A1 CA 002477094 A CA002477094 A CA 002477094A CA 2477094 A CA2477094 A CA 2477094A CA 2477094 A1 CA2477094 A1 CA 2477094A1
Authority
CA
Canada
Prior art keywords
polypeptide
ricin
ala
leu
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002477094A
Other languages
English (en)
Inventor
Mark A. Olson
Charles B. Millard
Michael P. Byrne
Robert W. Wannemacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Government
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2477094A1 publication Critical patent/CA2477094A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des polypeptides et des variantes de ceux-ci, comprenant une séquence polypeptidique possédant une similitude sensible avec la chaîne A du ricin (RTA), dénués d'activité d'ARNr-N-gylcosidase ou possédant une activité d'ARNr-N-glycosidase réduite par rapport aux témoins, ainsi que leurs procédés de fabrication et d'utilisation. Les polypeptides et variantes de l'invention sont plus solubles que RTA dans des solutions aqueuses à pH physiologique et à force ionique et conservent également l'intégrité de l'épitope immunologique neutralisant de la RTA de type sauvage. L'invention porte également sur des compositions immunogéniques pouvant être utilisées pour immuniser un sujet contre l'intoxication par le ricin. Des méthodes d'immunisation contre l'intoxication par le ricin, de traitement et de prévention de cette dernière sont également décrites.
CA002477094A 2002-02-27 2002-02-27 Vaccin a base de ricin et ses procedes de fabrication et d'utilisation Abandoned CA2477094A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/005732 WO2003072018A2 (fr) 2002-02-27 2002-02-27 Vaccin a base de ricin et ses procedes de fabrication et d'utilisation

Publications (1)

Publication Number Publication Date
CA2477094A1 true CA2477094A1 (fr) 2003-09-04

Family

ID=27765157

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002477094A Abandoned CA2477094A1 (fr) 2002-02-27 2002-02-27 Vaccin a base de ricin et ses procedes de fabrication et d'utilisation

Country Status (4)

Country Link
EP (1) EP1485497A4 (fr)
AU (1) AU2002252102A1 (fr)
CA (1) CA2477094A1 (fr)
WO (1) WO2003072018A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9133253B2 (en) * 2010-04-22 2015-09-15 The United States Of America As Represented By The Secretary Of The Army Ricin vaccine and methods of making thereof
US10208108B2 (en) 2014-11-28 2019-02-19 The Israel Institute of Biological Research (IIBR) Antibodies directed to ricin toxin
US10233256B2 (en) 2014-11-28 2019-03-19 The Israel Institute of Biological Research (IIBR) Antibodies directed to ricin toxin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0623679B1 (fr) * 1987-05-21 2003-06-25 Micromet AG Protéines multifonctionneles à cible prédéterminée
US5626844A (en) * 1991-11-04 1997-05-06 The United States Of America As Represented By The Secretary Of The Army Monoclonal antibody against ricin A chain
EP0909322B1 (fr) * 1996-04-30 2005-11-16 Twinstrand Therapeutics Inc. Proteines antivirales du type ricin
US6531125B1 (en) * 1999-03-02 2003-03-11 Twinstrand Therapeutics Inc. Antiviral ricin-like proteins

Also Published As

Publication number Publication date
WO2003072018A3 (fr) 2004-01-29
WO2003072018A2 (fr) 2003-09-04
EP1485497A4 (fr) 2005-07-27
AU2002252102A1 (en) 2003-09-09
EP1485497A2 (fr) 2004-12-15

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued