CA2474242A1 - Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light - Google Patents
Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light Download PDFInfo
- Publication number
- CA2474242A1 CA2474242A1 CA002474242A CA2474242A CA2474242A1 CA 2474242 A1 CA2474242 A1 CA 2474242A1 CA 002474242 A CA002474242 A CA 002474242A CA 2474242 A CA2474242 A CA 2474242A CA 2474242 A1 CA2474242 A1 CA 2474242A1
- Authority
- CA
- Canada
- Prior art keywords
- photosensitizer
- treatment chamber
- light
- fluid
- radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003504 photosensitizing agent Substances 0.000 title claims abstract 26
- 239000010836 blood and blood product Substances 0.000 title claims abstract 8
- 239000000356 contaminant Substances 0.000 title 1
- 239000012530 fluid Substances 0.000 claims abstract 23
- 238000000034 method Methods 0.000 claims abstract 21
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract 10
- 244000052769 pathogen Species 0.000 claims abstract 8
- 229940125691 blood product Drugs 0.000 claims abstract 7
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract 5
- 229960002477 riboflavin Drugs 0.000 claims abstract 5
- 235000019192 riboflavin Nutrition 0.000 claims abstract 5
- 239000002151 riboflavin Substances 0.000 claims abstract 5
- 230000005855 radiation Effects 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 6
- 238000001914 filtration Methods 0.000 claims 5
- 210000003743 erythrocyte Anatomy 0.000 claims 4
- 230000000415 inactivating effect Effects 0.000 claims 4
- 230000001678 irradiating effect Effects 0.000 claims 3
- 239000000463 material Substances 0.000 claims 2
- 125000001452 riboflavin group Chemical group 0.000 claims 2
- 238000002211 ultraviolet spectrum Methods 0.000 claims 2
- 230000002779 inactivation Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0047—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0076—Radiation using a photocatalyst or photosensitiser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3681—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation
- A61M1/3683—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by irradiation using photoactive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
- A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
- A61M2205/053—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy ultraviolet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
Abstract
Methods and apparatuses are provided for inactivation of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.
Claims (38)
1. A method for inactivating pathogens in a fluid containing red blood cells comprising;
adding a photosensitizer to the fluid to form a mixture, and exposing the mixture of the fluid and the photosensitizer to light having a peak wavelength of approximately 470 nm.
adding a photosensitizer to the fluid to form a mixture, and exposing the mixture of the fluid and the photosensitizer to light having a peak wavelength of approximately 470 nm.
2. The method of claim 1 wherein the step of exposing further comprises pulsing the light.
3. The method of claim 1 wherein the photosensitizer is an endogenous photosensitizer.
4. The method of claim 1 wherein the photosensitizer is an isoalloxazine.
5. The method of claim 1 wherein the photosensitizer is riboflavin.
6. A method for inactivating pathogens in a fluid containing platelets comprising;
adding a photosensitizer to the fluid to form a mixture, and exposing the mixture of the fluid and the photosensitizer to light within an approximate range of between 305-313 nm.
adding a photosensitizer to the fluid to form a mixture, and exposing the mixture of the fluid and the photosensitizer to light within an approximate range of between 305-313 nm.
7. A method of claim 6 wherein the step of exposing further comprises exposing the mixture to light having a peak wavelength at 308 nm.
8. The method of claim 6 wherein the exposing step further comprises exposing the mixture to pulsed light at the peak wavelength.
9. The method of claim 6 wherein the photosensitizer is an endogenous photosensitizer.
10. The method of claim 6 wherein the photosensitizer is an isoalloxazine.
11. The method of claim 6 wherein the photosensitizer is riboflavin.
12. A treatment chamber for inactivating pathogens in a fluid containing red blood cells and a photosensitizer comprising:
at least one radiation emitting source emitting radiation at a peak wavelength of approximately 470 nm;
a support platform for holding the fluid containing red blood cells and photosensitizer to be irradiated; and a control unit for controlling the radiation emitting source.
at least one radiation emitting source emitting radiation at a peak wavelength of approximately 470 nm;
a support platform for holding the fluid containing red blood cells and photosensitizer to be irradiated; and a control unit for controlling the radiation emitting source.
13. The treatment chamber of claim 12 wherein the radiation emitting source is capable of being pulsed.
14. The treatment chamber of claim 12 wherein the support platform is capable of movement in multiple directions within the treatment chamber.
15. The treatment chamber of claim 14 wherein the control unit further controls the movement of the support platform.
16. The treatment chamber of claim 12 wherein the support platform is made of photopermeable material.
17. The treatment chamber of claim 12 wherein the chamber further comprises at least one reflective surface.
18. The treatment chamber of claim 12 wherein the support platform includes a reflective surface.
19. The treatment chamber of claim 12 wherein the radiation emitting source further comprises an array containing a plurality of discrete lights.
20. The treatment chamber of claim 19 wherein the array containing a plurality of discrete lights further comprises a plurality of LEDs.
21. The treatment chamber of claim 20 wherein the plurality of LEDs are blue.
22. The treatment chamber of claim 13 wherein the control unit further moves the support platform in coordination with the radiation pulses.
23. A treatment chamber for inactivating pathogens in a fluid containing platelets and a photosensitizer comprising:
at least one radiation emitting source emitting radiation at a peak wavelength of approximately 308 nm;
at least one radiation emitting source emitting radiation at a peak wavelength of approximately 308 nm;
24 a support platform for holding the fluid containing platelets and photosensitizer to be irradiated; and a control unit for controlling the radiation emitting source.
24. The treatment chamber of claim 23 wherein the radiation emitting source is capable of being pulsed.
24. The treatment chamber of claim 23 wherein the radiation emitting source is capable of being pulsed.
25. The treatment chamber of claim 23 wherein the support platform is capable of movement in multiple directions within the treatment chamber.
26. The treatment chamber of claim 25 wherein the control unit further controls the movement of the support platform.
27. The treatment chamber of claim 23 wherein the support platform is made of photopermeable material.
28. The treatment chamber of claim 23 wherein the chamber further comprises at least one reflective surface.
29. The treatment chamber of claim 23 wherein the support platform is made of a reflective surface.
30. The treatment chamber of claim 24 wherein the control unit further moves the support platform in coordination with the radiation pulses.
31. The method of claim 6 further comprising:
filtering out all light except light in the range of between 305-313 nm.
filtering out all light except light in the range of between 305-313 nm.
32. The method of claim 31 wherein the step of filtering comprises filtering out all light in the UV spectrum except light having a peak wavelength of approximately 308 nm.
33. The method of claim 31 wherein the step of filtering comprises filtering out all light in the UV spectrum except light having a peak wavelength of approximately 313 nm.
34. The method of claim 1 further comprising;
mixing the fluid and photosensitizer during the exposing step to expose the majority of the fluid to the light.
mixing the fluid and photosensitizer during the exposing step to expose the majority of the fluid to the light.
35. The method of claim 6 wherein the light is pulsed light.
36. A method of irradiating a fluid containing platelets comprising the steps of:
adding an amount of photosensitizer to the fluid necessary to inactivate any pathogens contained in the fluid;
exposing the fluid and photosensitizer to light at a wavelength of approximately 308 nm; and mixing the fluid and photosensitizer during the exposing step to expose the majority of the fluid to the light.
adding an amount of photosensitizer to the fluid necessary to inactivate any pathogens contained in the fluid;
exposing the fluid and photosensitizer to light at a wavelength of approximately 308 nm; and mixing the fluid and photosensitizer during the exposing step to expose the majority of the fluid to the light.
37. A method of irradiating red blood cells in a fluid contained within a photopermeable bag comprising the steps of:
adding riboflavin to the bag in an amount necessary to inactivate any pathogens contained in the fluid;
exposing the bag containing at least the fluid and riboflavin to a peak wavelength of light; and mixing the contents of the bag during the exposing step.
adding riboflavin to the bag in an amount necessary to inactivate any pathogens contained in the fluid;
exposing the bag containing at least the fluid and riboflavin to a peak wavelength of light; and mixing the contents of the bag during the exposing step.
38. A method of irradiating a blood product comprising the steps of:
a) adding an amount of photosensitizer necessary to inactivate any pathogens contained in the blood product;
b) pulsing a radiation source having a peak wavelength of light of approximately 470 nm to expose the blood product and photosensitizer to radiation at the peak wavelength;
c) pulsing the radiation source off to stop exposure of the blood product and photosensitizer to radiation;
d) mixing the blood product and photosensitizer during the step of pulsing the radiation source off; and e) repeating steps b), c) and d).
a) adding an amount of photosensitizer necessary to inactivate any pathogens contained in the blood product;
b) pulsing a radiation source having a peak wavelength of light of approximately 470 nm to expose the blood product and photosensitizer to radiation at the peak wavelength;
c) pulsing the radiation source off to stop exposure of the blood product and photosensitizer to radiation;
d) mixing the blood product and photosensitizer during the step of pulsing the radiation source off; and e) repeating steps b), c) and d).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35322302P | 2002-02-01 | 2002-02-01 | |
| US60/353,223 | 2002-02-01 | ||
| PCT/US2003/003359 WO2003063915A1 (en) | 2002-02-01 | 2003-02-03 | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2474242A1 true CA2474242A1 (en) | 2003-08-07 |
| CA2474242C CA2474242C (en) | 2011-05-17 |
Family
ID=27663187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2474242A Expired - Lifetime CA2474242C (en) | 2002-02-01 | 2003-02-03 | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1469891B1 (en) |
| JP (1) | JP4704684B2 (en) |
| CA (1) | CA2474242C (en) |
| DE (1) | DE60327166D1 (en) |
| WO (1) | WO2003063915A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4899040B2 (en) * | 2005-07-01 | 2012-03-21 | 国立大学法人 岡山大学 | Bilirubin denaturator and bilirubin dialysis machine |
| CA2689447C (en) | 2005-12-19 | 2013-02-12 | Lumen Associates, Inc. | Apparatus for irradiation of fluid with electromagnetic radiation |
| DE102005062410A1 (en) | 2005-12-23 | 2007-08-09 | Forschungsgemeinschaft Der Drk-Blutspendedienste E.V. | Method for irradiating platelet concentrates in flexible containers with ultraviolet light |
| DE102005062634A1 (en) | 2005-12-23 | 2007-06-28 | Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH | Method for inactivation of pathogens, e.g. bacteria and viruses in donor blood, blood plasma and erythrocyte concentrations, involves filling exposure bag with supplement to less than thirty percent volume of maximum volume of exposure bag |
| EP1902740A1 (en) * | 2006-09-19 | 2008-03-26 | Maco Pharma S.A. | Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system |
| JP2008161095A (en) * | 2006-12-27 | 2008-07-17 | Univ Of Tokushima | Apparatus for ultraviolet ray sterilization, and method for ultraviolet ray sterilization |
| EP2008669A1 (en) | 2007-06-22 | 2008-12-31 | Maco Pharma S.A. | Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process |
| JP5008103B2 (en) * | 2007-07-02 | 2012-08-22 | テルモ ビーシーティー バイオテクノロジーズ，エルエルシー | Device for photoreducing pollutants in blood and blood products using measuring means |
| WO2010141564A2 (en) * | 2009-06-02 | 2010-12-09 | Ceramoptec Industries, Inc. | A novel method for microbial depletion in human blood and blood products using antimicrobial photodynamic therapy |
| CN102725024B (en) * | 2010-01-19 | 2017-05-31 | 拜欧利泰克投资二代公司 | Enhanced antibacterial PDT |
| US20140127077A1 (en) * | 2012-11-05 | 2014-05-08 | Gail Rock | Device and method for sterilization of instruments and surfaces |
| US9700072B2 (en) | 2014-09-30 | 2017-07-11 | Sensor Electronic Technology, Inc. | Movable ultraviolet radiation source |
| CN104667364A (en) * | 2015-02-11 | 2015-06-03 | 杨萌 | Hybrid light source light quantum blood irradiation device |
| CN108778357B (en) * | 2016-03-23 | 2021-12-03 | 泰尔茂株式会社 | Light irradiation device |
| US11771814B2 (en) | 2018-07-27 | 2023-10-03 | Terumo Bct Biotechnologies, Llc | Flow cell |
| KR20230000552U (en) * | 2020-05-20 | 2023-03-16 | 휴 잉 람 | Carrying bag for object sterilization |
| WO2021232462A1 (en) * | 2020-05-20 | 2021-11-25 | Juladore Limited | A portable bag for sterilizing an object |
| CN114366831A (en) * | 2022-01-10 | 2022-04-19 | 南京双威生物医学科技有限公司 | Plasma pathogen inactivation treatment method based on riboflavin photochemical method |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3930510A1 (en) * | 1989-09-13 | 1991-03-21 | Blutspendedienst Dt Rote Kreuz | PROCESS FOR INACTIVATING VIRUSES IN BLOOD AND BLOOD PRODUCTS |
| US6258577B1 (en) * | 1998-07-21 | 2001-07-10 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using endogenous alloxazine or isoalloxazine photosensitizers |
| US7094378B1 (en) * | 2000-06-15 | 2006-08-22 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| DE10031851B4 (en) * | 2000-07-04 | 2005-10-13 | Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH | Photodynamic treatment and UV-B irradiation of a platelet suspension |
| AU2001296309A1 (en) * | 2000-09-27 | 2002-04-08 | Gambro, Inc | Inactivation of contaminants using photosensitizers and pulsed light |
| EP1471940B1 (en) * | 2002-02-01 | 2009-01-07 | CaridianBCT Biotechnologies, LLC | Inactivation of west nile virus and plasmodium falciparum using alloxazine-derivating photosensitisers |
-
2003
- 2003-02-03 CA CA2474242A patent/CA2474242C/en not_active Expired - Lifetime
- 2003-02-03 DE DE60327166T patent/DE60327166D1/en not_active Expired - Lifetime
- 2003-02-03 WO PCT/US2003/003359 patent/WO2003063915A1/en active Application Filing
- 2003-02-03 JP JP2003563604A patent/JP4704684B2/en not_active Expired - Lifetime
- 2003-02-03 EP EP03706079A patent/EP1469891B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1469891A1 (en) | 2004-10-27 |
| JP4704684B2 (en) | 2011-06-15 |
| EP1469891B1 (en) | 2009-04-15 |
| JP2005516978A (en) | 2005-06-09 |
| WO2003063915A1 (en) | 2003-08-07 |
| CA2474242C (en) | 2011-05-17 |
| DE60327166D1 (en) | 2009-05-28 |
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