CA2470350A1 - Centrifugal filling of sample processing devices - Google Patents

Centrifugal filling of sample processing devices Download PDF

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Publication number
CA2470350A1
CA2470350A1 CA002470350A CA2470350A CA2470350A1 CA 2470350 A1 CA2470350 A1 CA 2470350A1 CA 002470350 A CA002470350 A CA 002470350A CA 2470350 A CA2470350 A CA 2470350A CA 2470350 A1 CA2470350 A1 CA 2470350A1
Authority
CA
Canada
Prior art keywords
sample processing
processing device
process chambers
chambers
loading
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002470350A
Other languages
French (fr)
Other versions
CA2470350C (en
Inventor
William Bedingham
Joel R. Dufresne
Michael R. Harms
Richard R. Matner
Diane North
Kenneth B. Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2714073A priority Critical patent/CA2714073A1/en
Publication of CA2470350A1 publication Critical patent/CA2470350A1/en
Application granted granted Critical
Publication of CA2470350C publication Critical patent/CA2470350C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Centrifugal Separators (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

The present invention provides methods and devices for distributing sample material to a plurality of process chambers (50) in a sample processing devi ce (10) by rotating the device about an axis of rotation. The process chambers are located along conduits(40) extending from a loading chamber and, togethe r, the loading chamber, conduits, and process chambers form process arrays that are aligned along a length of the sample processing devices. The process arrays are unvented, i.e., access to the interior volume of the process arra ys is available only through the loading chamber. Also disclosed are methods of centrifugally loading sample material into the process chambers, as well as an assembly including a sample processing device and a carrier.

Claims (15)

1. A method of distributing sample material in a sample processing device, the method comprising:
providing a sample processing device that comprises first and second opposing ends and at least one unvented process array comprising a loading chamber located proximate the first end, a main conduit extending towards the second end, and a plurality of process chambers distributed along the main conduit, wherein the main conduit is in fluid communication with the loading chamber and the plurality of process chambers;
loading sample material in the loading chamber of each of the process arrays; and transporting the sample material to at least some of the process chambers by rotating the sample processing device about an axis of rotation located proximate the first end of the sample processing device, wherein the process chambers are located further from the axis of rotation than the loading chambers.
2. A method according to claim 1, further comprising closing the main conduits between the loading chambers and the plurality of process chambers after transporting the sample material, wherein the closing comprises folding the sample processing device along a line located between the loading chambers and the plurality of process chambers.
3. A method according to claim 1, further comprising separating the loading chambers from the sample processing device after transporting the sample material to the process chambers.
4. A method according to claim 3, further comprising closing the main conduits between the loading chambers and the plurality of process chambers after transporting the sample material and before separating the loading chambers.
5. A method according to claim 1, further comprising vibrating the sample processing device while rotating the sample processing device about the axis of rotation located proximate the first end of the sample processing device.
6. The method of claim 1, wherein each of the process chambers is in fluid communication with the main conduit through a feeder conduit, and further wherein the feeder conduits form feeder conduit angles with the main conduit that are less than 90 degrees.
7. A method according to claim 1, wherein the rotating during transporting the sample material comprises at least two acceleration/deceleration cycles.
8. A sample processing assembly comprising:
a sample processing device comprising first and second opposing ends and at least one unvented process array comprising a loading chamber located proximate the first end, a main conduit extending towards the second end, and a plurality of process chambers distributed along the main conduit, wherein the main conduit is in fluid communication with the loading chamber and the plurality of process chambers;
and a carrier attached to a first major side of the sample processing device, the carrier comprising a carrier body spaced from at least a portion of the first major side of the sample processing device.
9. The assembly of claim 8, wherein the carrier comprises a plurality of carrier openings, the plurality of carrier openings aligned with the plurality of process chambers in the sample processing device.
10. The assembly of claim 8, wherein the carrier comprises a rail aligned with the each of the main conduits on the sample processing device, wherein the carrier body is spaced from the sample processing device between adjacent main conduits.
11. A sample processing device comprising:

first and second opposing ends;
a plurality of unvented process arrays, each of the process arrays comprising a loading chamber located proximate the first end; a main conduit extending towards the second end; and a plurality of process chambers distributed along the main conduit, wherein the main conduit is in fluid communication with the loading chamber and the plurality of process chambers; and wherein each of the process chambers is in fluid communication with one of the main conduits through a feeder conduit, and wherein the feeder conduits form feeder conduit angles with the main conduits that are less than 90°.
12. The device of claim 11, wherein the process chambers are elongated along an axis extending between the first and second opposing ends of the sample processing device.
13. The device of claim 11, wherein the feeder conduits enter the process chambers proximate the first end of the device.
14. The device of claim 11, wherein the sample processing device comprises first and second major sides attached with a layer of pressure sensitive adhesive, and wherein at least one of the main conduits is closed between the process chambers and the loading chamber by the pressure sensitive adhesive adhering to the first and second major sides together along the main conduit.
15. The device of claim 11, further comprising a separation line located between the loading chambers and the plurality of process chambers, the separation line extending across the main conduits of each of the process arrays.
CA2470350A 2001-12-21 2001-12-21 Centrifugal filling of sample processing devices Expired - Fee Related CA2470350C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2714073A CA2714073A1 (en) 2001-12-21 2001-12-21 Centrifugal filling of sample processing devices

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2001/050114 WO2003057369A1 (en) 2001-12-21 2001-12-21 Centrifugal filling of sample processing devices

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2714073A Division CA2714073A1 (en) 2001-12-21 2001-12-21 Centrifugal filling of sample processing devices

Publications (2)

Publication Number Publication Date
CA2470350A1 true CA2470350A1 (en) 2003-07-17
CA2470350C CA2470350C (en) 2010-11-09

Family

ID=21743162

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2470350A Expired - Fee Related CA2470350C (en) 2001-12-21 2001-12-21 Centrifugal filling of sample processing devices

Country Status (6)

Country Link
EP (1) EP1458482B1 (en)
JP (1) JP4181046B2 (en)
AT (1) ATE549084T1 (en)
AU (1) AU2002232786A1 (en)
CA (1) CA2470350C (en)
WO (1) WO2003057369A1 (en)

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US7460223B2 (en) 2003-09-19 2008-12-02 Applied Biosystems Inc. Inverted orientation for a microplate
JP3910208B2 (en) 2005-01-24 2007-04-25 松下電器産業株式会社 Liquid feeding device and liquid feeding method
TW200712495A (en) * 2005-08-02 2007-04-01 3M Innovative Properties Co Apparatus and method for detecting an analyte
TW200714898A (en) 2005-08-02 2007-04-16 3M Innovative Properties Co Apparatus and method for detecting an analyte
EP1820571B1 (en) * 2006-02-09 2009-05-27 Roche Diagnostics GmbH 3D structures based on 2D substrates
EP1878497A1 (en) 2006-07-14 2008-01-16 Roche Diagnostics GmbH Disposable for analyzing a liquid sample by nucleic acid amplification
US9121055B2 (en) 2008-04-24 2015-09-01 3M Innovative Properties Company Analysis of nucleic acid amplification curves using wavelet transformation
JP5131538B2 (en) * 2008-05-07 2013-01-30 セイコーエプソン株式会社 Reaction liquid filling method
EP2416160B1 (en) 2009-03-31 2021-08-18 Toppan Printing Co., Ltd. Sample analysis chip, sample analyzer using sample analysis chip, sample analysis method, and method of producing sample analysis chip
TWI523950B (en) * 2009-09-30 2016-03-01 凸版印刷股份有限公司 Nucleic acid analysis apparatus
EP2637788A1 (en) * 2010-11-10 2013-09-18 Boehringer Ingelheim Microparts GmbH Device for filtering blood
CN102886280B (en) * 2012-08-28 2014-06-11 博奥生物有限公司 Microfluidic chip and application thereof
CN108884430B (en) * 2016-04-20 2019-11-19 希森美康株式会社 Nucleic acid analyzer and method for nucleic acid analysis

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US4390499A (en) * 1981-08-13 1983-06-28 International Business Machines Corporation Chemical analysis system including a test package and rotor combination
US5288463A (en) * 1992-10-23 1994-02-22 Eastman Kodak Company Positive flow control in an unvented container
WO1994026414A1 (en) * 1993-05-17 1994-11-24 Syntex (U.S.A.) Inc. Reaction container for specific binding assays and method for its use
US5639428A (en) * 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
KR100306951B1 (en) * 1995-12-05 2001-11-15 테칸 보스턴, 인코포레이티드 Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
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WO2001007892A1 (en) * 1999-07-27 2001-02-01 Esperion Therapeutics, Inc. Method and device for measurement of cholesterol efflux

Also Published As

Publication number Publication date
EP1458482B1 (en) 2012-03-14
EP1458482A1 (en) 2004-09-22
ATE549084T1 (en) 2012-03-15
JP4181046B2 (en) 2008-11-12
CA2470350C (en) 2010-11-09
JP2005537911A (en) 2005-12-15
AU2002232786A1 (en) 2003-07-24
WO2003057369A1 (en) 2003-07-17

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Effective date: 20121221