CA2469714A1 - Anticorps monoclonaux multifonctionnels diriges contre le peptidoglycane de bacteries gram-positif - Google Patents
Anticorps monoclonaux multifonctionnels diriges contre le peptidoglycane de bacteries gram-positif Download PDFInfo
- Publication number
- CA2469714A1 CA2469714A1 CA002469714A CA2469714A CA2469714A1 CA 2469714 A1 CA2469714 A1 CA 2469714A1 CA 002469714 A CA002469714 A CA 002469714A CA 2469714 A CA2469714 A CA 2469714A CA 2469714 A1 CA2469714 A1 CA 2469714A1
- Authority
- CA
- Canada
- Prior art keywords
- mab
- medicament
- patient
- gram
- positive bacteria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 241000192125 Firmicutes Species 0.000 title claims abstract 10
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 title claims abstract 7
- 108010013639 Peptidoglycan Proteins 0.000 title claims abstract 7
- 230000001681 protective effect Effects 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims 17
- 238000000034 method Methods 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 241000194107 Bacillus megaterium Species 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 206010061598 Immunodeficiency Diseases 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000194019 Streptococcus mutans Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000941 anti-staphylcoccal effect Effects 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000007913 intrathecal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000007914 intraventricular administration Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000009871 nonspecific binding Effects 0.000 claims 1
- 230000000625 opsonophagocytic effect Effects 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract 2
- 206010057249 Phagocytosis Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000008782 phagocytosis Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1278—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1296—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Listeria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34344401P | 2001-12-21 | 2001-12-21 | |
| US34180601P | 2001-12-21 | 2001-12-21 | |
| US60/341,806 | 2001-12-21 | ||
| US60/343,444 | 2001-12-21 | ||
| PCT/US2002/041032 WO2003059259A2 (fr) | 2001-12-21 | 2002-12-23 | Anticorps monoclonaux multifonctionnels diriges contre le peptidoglycane de bacteries gram-positif |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2469714A1 true CA2469714A1 (fr) | 2003-07-24 |
Family
ID=26992674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002469714A Abandoned CA2469714A1 (fr) | 2001-12-21 | 2002-12-23 | Anticorps monoclonaux multifonctionnels diriges contre le peptidoglycane de bacteries gram-positif |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1470237A4 (fr) |
| JP (2) | JP2005524624A (fr) |
| AU (2) | AU2002364740A1 (fr) |
| CA (1) | CA2469714A1 (fr) |
| WO (1) | WO2003059259A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106749652A (zh) * | 2017-03-14 | 2017-05-31 | 天津喜诺生物医药有限公司 | 一种金黄色葡萄球菌肽聚糖的多克隆抗体 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210044318A (ko) * | 2006-06-06 | 2021-04-22 | 얀센 백신스 앤드 프리벤션 비.브이. | 장내구균에 대한 사멸활성을 갖는 인간결합분자 및 그것의 용도 |
| NZ572775A (en) * | 2006-06-06 | 2011-09-30 | Crucell Holland Bv | Human binding molecules having killing activity against enterococci and staphylococcus aureus and uses thereof |
| CA2654712C (fr) * | 2006-06-06 | 2015-05-05 | Crucell Holland B.V. | Molecules de liaison humaines presentant une activite bactericide contre les staphylocoques et leurs utilisations |
| JP2008255084A (ja) * | 2007-04-04 | 2008-10-23 | Isako Hashimoto | 抗花粉症剤または食品 |
| AU2009246510B2 (en) * | 2008-05-12 | 2014-02-13 | Strox Biopharmaceuticals, Llc | Staphylococcus aureus-specific antibody preparations |
| US20100260752A1 (en) * | 2009-01-23 | 2010-10-14 | Biosynexus Incorporated | Opsonic and protective antibodies specific for lipoteichoic acid of gram positive bacteria |
| CA2879272A1 (fr) | 2012-07-16 | 2014-01-23 | Robert G.K. DONALD | Saccharides et leurs utilisations |
| EP2975054A4 (fr) * | 2013-03-12 | 2016-11-23 | Zenyaku Kogyo Kk | Anticorps anti-staphylocoque, son procédé de fabrication et son utilisation |
| JP7366922B2 (ja) | 2018-10-25 | 2023-10-23 | 島津ダイアグノスティクス株式会社 | 集菌方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4596769A (en) * | 1984-03-05 | 1986-06-24 | Temple University | Monoclonal antibodies to peptidoglycan and methods of preparing same |
| US6610293B1 (en) * | 1997-06-16 | 2003-08-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
| US6936258B1 (en) * | 1999-03-19 | 2005-08-30 | Nabi Biopharmaceuticals | Staphylococcus antigen and vaccine |
| GB2356402B (en) * | 2000-07-22 | 2001-10-31 | Michael G Morgan | Use of radio-labelled antibody to bacterial compounds in the diagnosis of focal infection in humans |
-
2002
- 2002-12-23 WO PCT/US2002/041032 patent/WO2003059259A2/fr active Application Filing
- 2002-12-23 AU AU2002364740A patent/AU2002364740A1/en not_active Abandoned
- 2002-12-23 EP EP02806494A patent/EP1470237A4/fr not_active Withdrawn
- 2002-12-23 JP JP2003559424A patent/JP2005524624A/ja active Pending
- 2002-12-23 CA CA002469714A patent/CA2469714A1/fr not_active Abandoned
-
2009
- 2009-08-17 AU AU2009210372A patent/AU2009210372B2/en not_active Ceased
- 2009-08-24 JP JP2009193403A patent/JP2010013454A/ja not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106749652A (zh) * | 2017-03-14 | 2017-05-31 | 天津喜诺生物医药有限公司 | 一种金黄色葡萄球菌肽聚糖的多克隆抗体 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002364740A1 (en) | 2003-07-30 |
| WO2003059259A3 (fr) | 2004-06-17 |
| WO2003059259A2 (fr) | 2003-07-24 |
| AU2009210372B2 (en) | 2012-07-26 |
| EP1470237A2 (fr) | 2004-10-27 |
| JP2005524624A (ja) | 2005-08-18 |
| EP1470237A4 (fr) | 2006-02-01 |
| AU2009210372A1 (en) | 2009-09-10 |
| JP2010013454A (ja) | 2010-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140325 |