CA2463491C - Amelioration d'un traitement tumoral au moyen d'un champ magnetique - Google Patents
Amelioration d'un traitement tumoral au moyen d'un champ magnetique Download PDFInfo
- Publication number
- CA2463491C CA2463491C CA2463491A CA2463491A CA2463491C CA 2463491 C CA2463491 C CA 2463491C CA 2463491 A CA2463491 A CA 2463491A CA 2463491 A CA2463491 A CA 2463491A CA 2463491 C CA2463491 C CA 2463491C
- Authority
- CA
- Canada
- Prior art keywords
- magnetic field
- treatment system
- source
- tumor
- free radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000005291 magnetic effect Effects 0.000 title claims abstract description 50
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 45
- 238000011282 treatment Methods 0.000 title claims description 17
- 230000006798 recombination Effects 0.000 claims abstract description 8
- 238000005215 recombination Methods 0.000 claims abstract description 8
- 150000003254 radicals Chemical class 0.000 claims description 39
- 230000005855 radiation Effects 0.000 claims description 18
- 239000011324 bead Substances 0.000 claims description 6
- 230000002285 radioactive effect Effects 0.000 claims description 4
- 239000013043 chemical agent Substances 0.000 claims description 3
- 230000003068 static effect Effects 0.000 claims description 3
- 239000000696 magnetic material Substances 0.000 claims description 2
- 239000012857 radioactive material Substances 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims 5
- 230000005670 electromagnetic radiation Effects 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 5
- 210000001519 tissue Anatomy 0.000 description 8
- 239000013598 vector Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000001959 radiotherapy Methods 0.000 description 4
- 230000002476 tumorcidal effect Effects 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000981 bystander Effects 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 239000012829 chemotherapy agent Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 238000010505 homolytic fission reaction Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 230000005426 magnetic field effect Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 108010006654 Bleomycin Proteins 0.000 description 1
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- 238000013459 approach Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
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- 230000007717 exclusion Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005364 hyperfine coupling Effects 0.000 description 1
- 230000002977 hyperthermial effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
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- 230000007704 transition Effects 0.000 description 1
- 230000005428 wave function Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/002—Magnetotherapy in combination with another treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
- A61N1/403—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia
- A61N1/406—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals for thermotherapy, e.g. hyperthermia using implantable thermoseeds or injected particles for localized hyperthermia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Magnetic Treatment Devices (AREA)
Abstract
L'invention concerne une méthode de traitement d'une tumeur, consistant à créer une concentration élevée de radicaux libres dans ladite tumeur (22) et à créer un champ magnétique (20) traversant ladite tumeur (22) et inhibant la recombinaison des radicaux libres dans ladite tumeur. Un champ magnétique de 0,1 mTesla à 10 mTesla est généralement utilisé à cet effet.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32808501P | 2001-10-11 | 2001-10-11 | |
| US60/328,085 | 2001-10-11 | ||
| US34927002P | 2002-01-18 | 2002-01-18 | |
| US60/349,270 | 2002-01-18 | ||
| PCT/US2002/032444 WO2003030722A2 (fr) | 2001-10-11 | 2002-10-09 | Amelioration d'un traitement tumoral au moyen d'un champ magnetique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2463491A1 CA2463491A1 (fr) | 2003-04-17 |
| CA2463491C true CA2463491C (fr) | 2011-07-26 |
Family
ID=26986208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2463491A Expired - Lifetime CA2463491C (fr) | 2001-10-11 | 2002-10-09 | Amelioration d'un traitement tumoral au moyen d'un champ magnetique |
Country Status (4)
| Country | Link |
|---|---|
| AU (1) | AU2002343495A1 (fr) |
| CA (1) | CA2463491C (fr) |
| GB (1) | GB2396302B (fr) |
| WO (1) | WO2003030722A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2855067B1 (fr) | 2003-05-20 | 2005-06-24 | Emery Sa | Fixation de surf des neiges |
| CN107362445A (zh) * | 2017-08-30 | 2017-11-21 | 东北师范大学 | 抗癌靶向药物指向静电场合成矢量增强装置 |
| EP3727579B1 (fr) * | 2017-12-19 | 2021-10-06 | Medical Development Technologies S.A. | Dispositif d'implant chauffable pour traitement des tumeurs |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3163724D1 (en) * | 1980-04-29 | 1984-06-28 | Electro Biology Inc | Apparatus for treating an intact animal organism bearing a neoplastic process and undergoing drug treatment |
| US5156587A (en) * | 1983-09-01 | 1992-10-20 | Montone Liber J | Method for treating malignant cells |
| US4665898A (en) * | 1984-05-23 | 1987-05-19 | Maxwell Laboratories, Inc. | Malignancy treatment |
| WO1997004830A1 (fr) * | 1995-07-28 | 1997-02-13 | Gray James R | Utilisation d'un champ polarisant pour modifier l'efficacite d'un agent bioactif |
| US6261831B1 (en) * | 1999-03-26 | 2001-07-17 | The United States Of America As Represented By The Secretary Of The Air Force | Ultra-wide band RF-enhanced chemotherapy for cancer treatmeat |
-
2002
- 2002-10-09 WO PCT/US2002/032444 patent/WO2003030722A2/fr not_active Application Discontinuation
- 2002-10-09 GB GB0408373A patent/GB2396302B/en not_active Expired - Lifetime
- 2002-10-09 AU AU2002343495A patent/AU2002343495A1/en not_active Abandoned
- 2002-10-09 CA CA2463491A patent/CA2463491C/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003030722A3 (fr) | 2003-07-03 |
| GB2396302B (en) | 2006-05-31 |
| CA2463491A1 (fr) | 2003-04-17 |
| WO2003030722A2 (fr) | 2003-04-17 |
| GB0408373D0 (en) | 2004-05-19 |
| AU2002343495A1 (en) | 2003-04-22 |
| GB2396302A (en) | 2004-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20221011 |