CA2462681A1 - Prevention de maladies par reactivation du thymus - Google Patents
Prevention de maladies par reactivation du thymus Download PDFInfo
- Publication number
- CA2462681A1 CA2462681A1 CA002462681A CA2462681A CA2462681A1 CA 2462681 A1 CA2462681 A1 CA 2462681A1 CA 002462681 A CA002462681 A CA 002462681A CA 2462681 A CA2462681 A CA 2462681A CA 2462681 A1 CA2462681 A1 CA 2462681A1
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- lhrh
- thymus
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Abstract
La présente invention concerne des procédés de thérapie génique faisant appel à des cellules souches hématopoïétiques, des cellules progénitrices lymphoïdes et/ou de cellules progénitrices myéloïdes. Les cellules précitées sont génétiquement modifiées de façon qu'elles renferment un gène qui est exprimé dans ces cellules et leur descendance après différenciation. Dans un mode de réalisation préféré, les cellules contiennent un gène ou un fragment de gène qui confère aux cellules une résistance à l'infection au VIH et/ou à la réplication du VIH. Les cellules sont administrées à un patient en association avec un traitement destiné à réactiver le thymus du patient. Les cellules peuvent être autologues, syngéniques, allogéniques ou xénogéniques, étant donné que l'on crée chez le patient une tolérance aux cellules étrangères au cours de la réactivation du thymus. Dans un mode de réalisation préféré, les cellules souches hématopoïétiques sont des CD34?+¿. On réactive le thymus du patient en interrompant la signalisation médiée par les stéroïdes sexuels vers le thymus. Dans un mode de réalisation préféré, on crée cette interruption en administrant des agonistes de la LHRH, des anticorps anti-récepteurs à la LHRH, des vaccins anti-LHRH ou des combinaisons de ces derniers.
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79530200A | 2000-10-13 | 2000-10-13 | |
| US79528600A | 2000-10-13 | 2000-10-13 | |
| AUPR0745A AUPR074500A0 (en) | 2000-10-13 | 2000-10-13 | Treatment of t cell disorders |
| US09/795,302 | 2000-10-13 | ||
| US09/795,286 | 2000-10-13 | ||
| AUPR0745 | 2000-10-13 | ||
| US75598301A | 2001-01-05 | 2001-01-05 | |
| US75564601A | 2001-01-05 | 2001-01-05 | |
| US09/755,965 US20010046486A1 (en) | 2000-04-17 | 2001-01-05 | Stimulation of thymus for vaccination development |
| US09/755,965 | 2001-01-05 | ||
| US09/755,983 | 2001-01-05 | ||
| US09/755,646 | 2001-01-05 | ||
| US75891001A | 2001-01-10 | 2001-01-10 | |
| US09/758,910 | 2001-01-10 | ||
| US09/965,395 | 2001-09-26 | ||
| US09/965,395 US20020081276A1 (en) | 1999-04-15 | 2001-09-26 | Disease prevention by reactivation of the thymus |
| PCT/IB2001/002745 WO2002030259A2 (fr) | 2000-10-13 | 2001-10-12 | Prevention de maladies par reactivation du thymus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2462681A1 true CA2462681A1 (fr) | 2002-04-18 |
Family
ID=27570138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002462681A Abandoned CA2462681A1 (fr) | 2000-10-13 | 2001-10-12 | Prevention de maladies par reactivation du thymus |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1363703A4 (fr) |
| CN (1) | CN100406025C (fr) |
| AP (1) | AP2003002796A0 (fr) |
| AU (1) | AU1632302A (fr) |
| BR (1) | BR0114642A (fr) |
| CA (1) | CA2462681A1 (fr) |
| IL (1) | IL155414A0 (fr) |
| NZ (1) | NZ525830A (fr) |
| WO (1) | WO2002030259A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1620126A4 (fr) * | 2003-04-18 | 2007-07-04 | Norwood Immunology Ltd | Prevention de maladies et vaccination avant reactivation thymique |
| EP2197462A2 (fr) * | 2007-09-11 | 2010-06-23 | Mondobiotech Laboratories AG | Utilisation d'un peptide du recepteur de il-1, seule ou en combinaison avec un ester d-ala-gln-octadecyl, en tant qu'agent thérapeutique |
| CA2768965C (fr) | 2009-08-14 | 2019-06-04 | George N. Pavlakis | Utilisation d'il-15 pour ameliorer la production thymique et pour traiter la lymphopenie |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| GB2515941A (en) | 2011-10-21 | 2015-01-07 | Abbvie Inc | Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon |
| EA201490836A1 (ru) | 2011-10-21 | 2014-11-28 | Эббви Инк. | Комбинационное лечение (например, с abt-072 или abt-333) с помощью daa для применения при лечении hcv |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| CN109689063A (zh) | 2016-04-28 | 2019-04-26 | 埃默里大学 | 含有炔烃的核苷酸和核苷治疗组合物及其相关用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4049805A (en) * | 1975-09-30 | 1977-09-20 | Akzona Incorporated | Steroidal erythropoietic agents and therapeutic compositions and methods |
| CN1058500C (zh) * | 1993-02-03 | 2000-11-15 | 施塞克龙药品公司 | 胸腺素α－1衍生物 |
| DK0697876T3 (da) * | 1993-05-17 | 2002-09-09 | Gen Hospital Corp | Xenograftthymus |
| AUPP971499A0 (en) * | 1999-04-12 | 1999-05-06 | Opentec Pty. Limited | On-line electoral system |
| AUPP977899A0 (en) * | 1999-04-15 | 1999-05-13 | Monash University | Improvement of t cell mediated immunity |
-
2001
- 2001-10-12 NZ NZ525830A patent/NZ525830A/en unknown
- 2001-10-12 IL IL15541401A patent/IL155414A0/xx unknown
- 2001-10-12 EP EP01986582A patent/EP1363703A4/fr not_active Ceased
- 2001-10-12 CA CA002462681A patent/CA2462681A1/fr not_active Abandoned
- 2001-10-12 BR BR0114642-4A patent/BR0114642A/pt not_active IP Right Cessation
- 2001-10-12 AU AU1632302A patent/AU1632302A/xx active Pending
- 2001-10-12 CN CNB018201342A patent/CN100406025C/zh not_active Expired - Fee Related
- 2001-10-12 WO PCT/IB2001/002745 patent/WO2002030259A2/fr active IP Right Grant
- 2001-10-12 AP APAP/P/2003/002796A patent/AP2003002796A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ525830A (en) | 2005-07-29 |
| IL155414A0 (en) | 2003-11-23 |
| CN1505537A (zh) | 2004-06-16 |
| WO2002030259A2 (fr) | 2002-04-18 |
| EP1363703A2 (fr) | 2003-11-26 |
| AU1632302A (en) | 2002-04-22 |
| WO2002030259A9 (fr) | 2003-08-07 |
| CN100406025C (zh) | 2008-07-30 |
| BR0114642A (pt) | 2004-01-20 |
| AP2003002796A0 (en) | 2003-06-30 |
| WO2002030259A3 (fr) | 2002-07-04 |
| EP1363703A4 (fr) | 2006-06-07 |
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