CA2461491A1 - Methods of screening for antagonists of apm1/gzip - Google Patents

Methods of screening for antagonists of apm1/gzip Download PDF

Info

Publication number
CA2461491A1
CA2461491A1 CA002461491A CA2461491A CA2461491A1 CA 2461491 A1 CA2461491 A1 CA 2461491A1 CA 002461491 A CA002461491 A CA 002461491A CA 2461491 A CA2461491 A CA 2461491A CA 2461491 A1 CA2461491 A1 CA 2461491A1
Authority
CA
Canada
Prior art keywords
polypeptide
gzip
polypeptides
sequence
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002461491A
Other languages
English (en)
French (fr)
Inventor
Ilya Chumakov
Oxana Guerassimenko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Biodevelopment SAS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2461491A1 publication Critical patent/CA2461491A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002461491A 2001-10-05 2002-10-03 Methods of screening for antagonists of apm1/gzip Abandoned CA2461491A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32772501P 2001-10-05 2001-10-05
US60/327,725 2001-10-05
PCT/IB2002/004598 WO2003050281A2 (en) 2001-10-05 2002-10-03 Fragments of the human zn-alpha2-glycolprotein and their use in methods of treatment of obesity

Publications (1)

Publication Number Publication Date
CA2461491A1 true CA2461491A1 (en) 2003-06-19

Family

ID=23277766

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002461491A Abandoned CA2461491A1 (en) 2001-10-05 2002-10-03 Methods of screening for antagonists of apm1/gzip

Country Status (11)

Country Link
US (1) US7402393B2 (cg-RX-API-DMAC7.html)
EP (1) EP1432803B1 (cg-RX-API-DMAC7.html)
JP (1) JP4423038B2 (cg-RX-API-DMAC7.html)
AT (1) ATE380868T1 (cg-RX-API-DMAC7.html)
AU (1) AU2002339678B2 (cg-RX-API-DMAC7.html)
CA (1) CA2461491A1 (cg-RX-API-DMAC7.html)
DE (1) DE60224064T2 (cg-RX-API-DMAC7.html)
DK (1) DK1432803T3 (cg-RX-API-DMAC7.html)
ES (1) ES2295415T3 (cg-RX-API-DMAC7.html)
IL (2) IL161233A0 (cg-RX-API-DMAC7.html)
WO (1) WO2003050281A2 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1509545B8 (en) 2002-05-31 2010-10-13 Merck Serono Biodevelopment SAS Homotrimeric extended obg3 globular head and uses thereof
AU2003299378A1 (en) * 2002-10-11 2004-05-04 Board Of Regents, The University Of Texas System Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases
EP1548445A3 (en) * 2003-12-22 2005-11-23 F. Hoffmann-La Roche Ag Novel targets for obesity from fat tissue
US20100173829A1 (en) * 2008-11-07 2010-07-08 Aston University Glycoproteins Having Lipid Mobilizing Properties and Therapeutic Uses Thereof
US8892184B2 (en) 2010-10-18 2014-11-18 Siemens Medical Solutions Usa, Inc. Systems and methods for reducing interference in a dual modality imaging system
JP2015524808A (ja) * 2012-07-25 2015-08-27 ユニバーシティ・オブ・シンシナティ アポリポタンパク質aivを用いたi型糖尿病の治療法
US11213567B2 (en) * 2017-09-29 2022-01-04 L&C Bio Co., Ltd. ZAG-derived peptide and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9811465D0 (en) * 1998-05-29 1998-07-29 Tisdale Michael J Glycoproteins having lipid mobilising properties and therapeutic applications thereof
BR0107626A (pt) * 2000-01-14 2002-10-15 Genset Sa Cabeças globulares de obg3 e usos destes para diminuir a massa corporal
CA2462588A1 (en) * 2001-10-12 2003-04-24 Genset S.A. Ngzipa, ngzipd, pgzipa, and pgzipd polynucleotides and polypeptides and uses thereof

Also Published As

Publication number Publication date
DK1432803T3 (da) 2008-03-10
AU2002339678B2 (en) 2007-10-25
JP4423038B2 (ja) 2010-03-03
DE60224064T2 (de) 2008-11-20
DE60224064D1 (de) 2008-01-24
AU2002339678B8 (en) 2003-06-23
US7402393B2 (en) 2008-07-22
US20070054845A1 (en) 2007-03-08
IL161233A0 (en) 2004-09-27
AU2002339678A1 (en) 2003-06-23
EP1432803B1 (en) 2007-12-12
JP2005511088A (ja) 2005-04-28
IL161233A (en) 2010-05-17
EP1432803A2 (en) 2004-06-30
WO2003050281A2 (en) 2003-06-19
WO2003050281A3 (en) 2003-12-04
ATE380868T1 (de) 2007-12-15
ES2295415T3 (es) 2008-04-16

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131003